Search Results - "Sánchez, Julieta M."

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin by Díaz, Raquel, Pallarès, Victor, Cano‐Garrido, Olivia, Serna, Naroa, Sánchez‐García, Laura, Falgàs, Aïda, Pesarrodona, Mireia, Unzueta, Ugutz, Sánchez‐Chardi, Alejandro, Sánchez, Julieta M., Casanova, Isolda, Vázquez, Esther, Mangues, Ramón, Villaverde, Antonio

“…Under the unmet need of efficient tumor‐targeting drugs for oncology, a recombinant version of the plant toxin ricin (the modular protein T22‐mRTA‐H6) is…”
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Engineering Protein Nanoparticles Out from Components of the Human Microbiome by López‐Laguna, Hèctor, Sánchez‐García, Laura, Serna, Naroa, Voltà‐Durán, Eric, Sánchez, Julieta M., Sánchez‐Chardi, Alejandro, Unzueta, Ugutz, Łoś, Marcin, Villaverde, Antonio, Vázquez, Esther

“…Nanoscale protein materials are highly convenient as vehicles for targeted drug delivery because of their structural and functional versatility. Selective…”
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In Vitro Fabrication of Microscale Secretory Granules by López‐Laguna, Hèctor, Parladé, Eloi, Álamo, Patricia, Sánchez, Julieta M., Voltà‐Durán, Eric, Serna, Naroa, Sánchez‐García, Laura, Cano‐Garrido, Olivia, Sánchez‐Chardi, Alejandro, Villaverde, Antonio, Mangues, Ramón, Unzueta, Ugutz, Vázquez, Esther

“…Advanced medical treatments involving drug delivery require fully biocompatible materials with the ability to release functional drugs in a time‐prolonged way…”
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Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles by Sánchez, Julieta M, Sánchez-García, Laura, Pesarrodona, Mireia, Serna, Naroa, Sánchez-Chardi, Alejandro, Unzueta, Ugutz, Mangues, Ramón, Vázquez, Esther, Villaverde, Antonio

“…Protein materials are rapidly gaining interest in materials sciences and nanomedicine because of their intrinsic biocompatibility and full biodegradability…”
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Release of functional fibroblast growth factor-2 from artificial inclusion bodies by Serna, Naroa, Cano-Garrido, Olivia, Sánchez, Julieta M., Sánchez-Chardi, Alejandro, Sánchez-García, Laura, López-Laguna, Hèctor, Fernández, Ester, Vázquez, Esther, Villaverde, Antonio

“…Growth factors are required for cell proliferation and differentiation under physiological conditions but especially in the context of regenerative medicine…”
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Enhanced recombinant protein capture, purity and yield from crude bacterial cell extracts by N-Lauroylsarcosine-assisted affinity chromatography by Carratalá, Jose Vicente, Atienza-Garriga, Jan, López-Laguna, Hèctor, Vázquez, Esther, Villaverde, Antonio, Sánchez, Julieta M, Ferrer-Miralles, Neus

“…Recombinant proteins cover a wide range of biomedical, biotechnological, and industrial needs. Although there are diverse available protocols for their…”
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Engineering Secretory Amyloids for Remote and Highly Selective Destruction of Metastatic Foci by Céspedes, María Virtudes, Cano‐Garrido, Olivia, Álamo, Patricia, Sala, Rita, Gallardo, Alberto, Serna, Naroa, Falgàs, Aïda, Voltà‐Durán, Eric, Casanova, Isolda, Sánchez‐Chardi, Alejandro, López‐Laguna, Hèctor, Sánchez‐García, Laura, Sánchez, Julieta M., Unzueta, Ugutz, Vázquez, Esther, Mangues, Ramón, Villaverde, Antonio

“…Functional amyloids produced in bacteria as nanoscale inclusion bodies are intriguing but poorly explored protein materials with wide therapeutic potential…”
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An In Silico Methodology That Facilitates Decision Making in the Engineering of Nanoscale Protein Materials by Parladé, Eloi, Voltà-Durán, Eric, Cano-Garrido, Olivia, Sánchez, Julieta M, Unzueta, Ugutz, López-Laguna, Hèctor, Serna, Naroa, Cano, Montserrat, Rodríguez-Mariscal, Manuel, Vazquez, Esther, Villaverde, Antonio

“…Under the need for new functional and biocompatible materials for biomedical applications, protein engineering allows the design of assemblable polypeptides,…”
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Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles by Voltà-Durán, Eric, Serna, Naroa, Sánchez-García, Laura, Aviñó, Anna, Sánchez, Julieta M., López-Laguna, Hèctor, Cano-Garrido, Olivia, Casanova, Isolda, Mangues, Ramón, Eritja, Ramon, Vázquez, Esther, Villaverde, Antonio, Unzueta, Ugutz

“…The possibility to conjugate tumor-targeted cytotoxic nanoparticles and conventional antitumoral drugs in single pharmacological entities would open a wide…”
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Biofabrication of functional protein nanoparticles through simple His-tag engineering by López-Laguna, Hèctor, Sánchez, Julieta M, Carratalá, José Vicente, Rojas-Peña, Mauricio, Sánchez-García, Laura, Parladé, Eloi, Sánchez-Chardi, Alejandro, Voltà-Durán, Eric, Serna, Naroa, Cano-Garrido, Olivia, Flores, Sandra, Ferrer-Miralles, Neus, Nolan, Verónica, de Marco, Ario, Roher, Nerea, Unzueta, Ugutz, Vazquez, Esther, Villaverde, Antonio

“…We have developed a simple, robust, and fully transversal approach for the a-la-carte fabrication of functional multimeric nanoparticles with potential…”
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Artificial Inclusion Bodies for Clinical Development by Sánchez, Julieta M., López‐Laguna, Hèctor, Álamo, Patricia, Serna, Naroa, Sánchez‐Chardi, Alejandro, Nolan, Verónica, Cano‐Garrido, Olivia, Casanova, Isolda, Unzueta, Ugutz, Vazquez, Esther, Mangues, Ramon, Villaverde, Antonio

“…Bacterial inclusion bodies (IBs) are mechanically stable protein particles in the microscale, which behave as robust, slow‐protein‐releasing amyloids. Upon…”
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The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles by Voltà-Durán, Eric, Sánchez, Julieta M, Parladé, Eloi, Serna, Naroa, Vazquez, Esther, Unzueta, Ugutz, Villaverde, Antonio

“…Protein-based materials intended as nanostructured drugs or drug carriers are progressively gaining interest in nanomedicine, since their structure, assembly…”
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His-tag β-galactosidase supramolecular performance by Flores, Sandra S., Clop, Pedro D., Barra, José L., Argaraña, Carlos E., Perillo, María A., Nolan, Verónica, Sánchez, Julieta M.

“…β-Galactosidase is an important biotechnological enzyme used in the dairy industry, pharmacology and in molecular biology. In our laboratory we have…”
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Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids by Sánchez, Julieta M., López‐Laguna, Hèctor, Parladé, Eloi, Somma, Angela Di, Livieri, Andrea L., Álamo, Patricia, Mangues, Ramón, Unzueta, Ugutz, Villaverde, Antonio, Vázquez, Esther

“…Developing time‐sustained drug delivery systems is a main goal in innovative medicines. Inspired by the architecture of secretory granules from the mammalian…”
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Efficient Delivery of Antimicrobial Peptides in an Innovative, Slow-Release Pharmacological Formulation by Serna, Naroa, López-Laguna, Hèctor, Aceituno, Patricia, Rojas-Peña, Mauricio, Parladé, Eloi, Voltà-Durán, Eric, Martínez-Torró, Carlos, Sánchez, Julieta M, Di Somma, Angela, Carratalá, Jose Vicente, Livieri, Andrea L, Ferrer-Miralles, Neus, Vázquez, Esther, Unzueta, Ugutz, Roher, Nerea, Villaverde, Antonio

“…Both nanostructure and multivalency enhance the biological activities of antimicrobial peptides (AMPs), whose mechanism of action is cooperative. In addition,…”
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Recombinant Proteins for Assembling as Nano- and Micro-Scale Materials for Drug Delivery: A Host Comparative Overview by Corchero, José Luis, Favaro, Marianna T P, Márquez-Martínez, Merce, Lascorz, Jara, Martínez-Torró, Carlos, Sánchez, Julieta M, López-Laguna, Hèctor, de Souza Ferreira, Luís Carlos, Vázquez, Esther, Ferrer-Miralles, Neus, Villaverde, Antonio, Parladé, Eloi

“…By following simple protein engineering steps, recombinant proteins with promising applications in the field of drug delivery can be assembled in the form of…”
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Nanostructure Empowers Active Tumor Targeting in Ligand‐Based Molecular Delivery by López‐Laguna, Hèctor, Sala, Rita, Sánchez, Julieta M., Álamo, Patricia, Unzueta, Ugutz, Sánchez‐Chardi, Alejandro, Serna, Naroa, Sánchez‐García, Laura, Voltà‐Durán, Eric, Mangues, Ramón, Villaverde, Antonio, Vázquez, Esther

“…Cell‐selective targeting is expected to enhance effectiveness and minimize side effects of cytotoxic agents. Functionalization of drugs or drug nanoconjugates…”
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In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics by Carratalá, Jose V, Brouillette, Eric, Serna, Naroa, Sánchez-Chardi, Alejandro, Sánchez, Julieta M, Villaverde, Antonio, Arís, Anna, Garcia-Fruitós, Elena, Ferrer-Miralles, Neus, Malouin, François

“…Oligomerization of antimicrobial peptides into nanosized supramolecular complexes produced in biological systems (inclusion bodies and self-assembling…”
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Biofabrication of Self-Assembling Covalent Protein Nanoparticles through Histidine-Templated Cysteine Coupling by López-Laguna, Hèctor, Rueda, Ariana, Martínez-Torró, Carlos, Sánchez-Alba, Lucía, Carratalá, José Vicente, Atienza-Garriga, Jan, Parladé, Eloi, Sánchez, Julieta M., Serna, Naroa, Voltà-Durán, Eric, Ferrer-Miralles, Neus, Reverter, David, Mangues, Ramon, Villaverde, Antonio, Vázquez, Esther, Unzueta, Ugutz

“…Nanoscale protein materials show increasing applications in biotechnology and biomedicine, addressing catalysis, drug delivery, or tissue engineering. Although…”
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The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles by Voltà-Durán, Eric, Sánchez, Julieta M., López-Laguna, Hèctor, Parladé, Eloi, Sánchez-García, Laura, Sánchez-Chardi, Alejandro, de Marco, Ario, Unzueta, Ugutz, Vázquez, Esther, Villaverde, Antonio

“…Histidine-rich peptides confer self-assembling properties to recombinant proteins through the supramolecular coordination with divalent cations. This fact…”
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