Search Results - "Sánchez, Gladis"

Na,K-ATPase α4, and Not Na,K-ATPase α1, is the Main Contributor to Sperm Motility, But its High Ouabain Binding Affinity Site is Not Required for Male Fertility in Mice by McDermott, Jeff P., Sánchez, Gladis, Mitra, Amrita, Numata, September, Liu, Lijun Catherine, Blanco, Gustavo

“…Mammalian sperm express two Na,K-ATPase (NKA) isoforms, Na,K-ATPase α4 (NKAα4) and Na,K-ATPase α1 (NKAα1). While NKAα4 is critical to sperm motility, the role…”
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Design, Synthesis, and in Vitro and in Vivo Evaluation of Ouabain Analogues as Potent and Selective Na,K-ATPase α4 Isoform Inhibitors for Male Contraception by Syeda, Shameem Sultana, Sánchez, Gladis, Hong, Kwon Ho, Hawkinson, Jon E, Georg, Gunda I, Blanco, Gustavo

“…Na,K-ATPase α4 is a testis-specific plasma membrane Na+ and K+ transporter expressed in sperm flagellum. Deletion of Na,K-ATPase α4 in male mice results in…”
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The Na+ and K+ transport system of sperm (ATP1A4) is essential for male fertility and an attractive target for male contraception by Syeda, Shameem Sultana, Sánchez, Gladis, McDermott, Jeffrey P, Hong, Kwon Ho, Blanco, Gustavo, Georg, Gunda I

“…One of the mechanisms that cells have developed to fulfil their specialized tasks is to express different molecular variants of a particular protein that has…”
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Na,K-ATPase α4 isoform is essential for sperm fertility by Jimenez, Tamara, McDermott, Jeffrey P, Sánchez, Gladis, Blanco, Gustavo

“…Regulation of ion balance in spermatozoa has been shown to be essential for sperm motility and fertility. Control of intracellular ion levels requires the…”
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Role of human Na,K-ATPase alpha 4 in sperm function, derived from studies in transgenic mice by McDermott, Jeffrey, Sánchez, Gladis, Nangia, Ajay K., Blanco, Gustavo

“…SUMMARY Most of our knowledge on the biological role of the testis‐specific Na,K‐ATPase alpha 4 isoform derives from studies performed in non‐human species…”
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Activity of the Na,K‐ATPase α4 Isoform Is Regulated During Sperm Capacitation to Support Sperm Motility by Jimenez, Tamara, Sánchez, Gladis, Blanco, Gustavo

“…: The α4 polypeptide is a testis‐specific isoform of the catalytic subunit of the Na,K‐ATPase, which is essential for sperm motility and fertility. In the…”
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Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation by Nguyen, Anh-Nguyet T, Jansson, Kyle, Sánchez, Gladis, Sharma, Madhulika, Reif, Gail A, Wallace, Darren P, Blanco, Gustavo

“…The Na-K-ATPase is part of a cell signaling complex, the Na-K-ATPase signalosome, which upon activation by the hormone ouabain regulates the function of…”
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Isoform specificity of Na-K-ATPase-mediated ouabain signaling by Pierre, Sandrine V, Sottejeau, Yoann, Gourbeau, Jean-Michel, Sánchez, Gladis, Shidyak, Amjad, Blanco, Gustavo

“…The ion transporter Na-K-ATPase functions as a cell signal transducer that mediates ouabain-induced activation of protein kinases, such as ERK. While…”
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Activity of the Na,K-ATPase α4 isoform is important for membrane potential, intracellular Ca2+, and pH to maintain motility in rat spermatozoa by Jimenez, Tamara, Sánchez, Gladis, Wertheimer, Eva, Blanco, Gustavo

“…While the function of the ubiquitous Na,K-ATPase α1 subunit has been well documented, the role of the sperm-specific α4 isoform of this ion transporter is less…”
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The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertility by Numata, September, McDermott, Jeff P., Sanchez, Gladis, Mitra, Amrita, Blanco, Gustavo

“…Glucose is a key substrate for supporting sperm energy production and function. Previous studies have demonstrated that sperm glucose uptake is facilitated by…”
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The α4 Isoform of the Na,K-ATPase Is Expressed in the Germ Cells of the Testes by Blanco, Gustavo, Sánchez, Gladis, Melton, Roger J., Tourtellotte, Warren G., Mercer, Robert W.

“…In addition to the three isoforms of the catalytic subunit of the Na,K-ATPase originally identified (α1, α2, and α3), a fourth α polypeptide (α4) has recently…”
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Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells by Venugopal, Jessica, McDermott, Jeffrey, Sanchez, Gladis, Sharma, Madhulika, Barbosa, Leandro, Reif, Gail A., Wallace, Darren P., Blanco, Gustavo

“…The hormone ouabain has been shown to enhance the cystic phenotype of autosomal dominant polycystic kidney disease (ADPKD). Among other characteristics, the…”
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21-Benzylidene digoxin decreases proliferation by inhibiting the EGFR/ERK signaling pathway and induces apoptosis in HeLa cells by Pessôa, Marco Túlio C., Valadares, Jéssica M.M., Rocha, Sayonarah C., Silva, Simone C., McDermott, Jeff P., Sánchez, Gladis, Varotti, Fernando P., Scavone, Cristóforo, Ribeiro, Rosy I.M.A., Villar, José A.F.P., Blanco, Gustavo, Barbosa, Leandro A.

“…[Display omitted] •21-Benzylidene digoxin (21-BD) reduces the proliferation of HeLa cancer cells.•21-BD counteracts an insulin-stimulated proliferation of HeLa…”
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Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells by Jansson, Kyle, Venugopal, Jessica, Sánchez, Gladis, Magenheimer, Brenda S., Reif, Gail A., Wallace, Darren P., Calvet, James P., Blanco, Gustavo

“…Cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) requires the transepithelial secretion of fluid into the cyst lumen. We previously…”
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The Na,K-ATPase α4 isoform from humans has distinct enzymatic properties and is important for sperm motility by Sanchez, Gladis, Nguyen, Anh-Nguyet T., Timmerberg, Brady, Tash, Joseph S., Blanco, Gustavo

“…In the rat, the Na,K-ATPase α4 isoform exhibits unique enzymatic characteristics and is important for sperm motility. In this work, we studied expression,…”
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Increased Expression of the Na,K-ATPase alpha4 Isoform Enhances Sperm Motility in Transgenic Mice1 by Jimenez, Tamara, Sanchez, Gladis, McDermott, Jeffrey P, Nguyen, Anh-Nguyet, Kumar, T. Rajendra, Blanco, Gustavo

“…The Na,K-ATPase alpha4 (ATP1A4) isoform is specifically expressed in male germ cells and is highly prevalent in spermatozoa. Although selective inhibition of…”
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Green fluorescence protein driven by the Na,K-ATPase α4 isoform promoter is expressed only in male germ cells of mouse testis by McDermott, Jeffrey P., Sánchez, Gladis, Chennathukuzhi, Vargheese, Blanco, Gustavo

“…Purpose Expression of the Na,K-ATPase α4 isoform is required for sperm motility and fertility and is controlled by the Atp1a4 promoter. Here, we have…”
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Na,K-ATPase [alpha]4 isoform is essential for sperm fertility by Jimenez, Tamara, McDermott, Jeffrey P, Sánchez, Gladis, Blanco, Gustavo

“…Regulation of ion balance in spermatozoa has been shown to be essential for sperm motility and fertility. Control of intracellular ion levels requires the…”
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Green fluorescence protein driven by the Na,K-ATPase [alpha]4 isoform promoter is expressed only in male germ cells of mouse testis by Mcdermott, Jeffrey P, Sánchez, Gladis, Chennathukuzhi, Vargheese, Blanco, Gustavo

“…Expression of the Na,K-ATPase [alpha]4 isoform is required for sperm motility and fertility and is controlled by the Atp1a4 promoter. Here, we have…”
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Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease by Trant, Jordan, Sanchez, Gladis, McDermott, Jeffrey P, Blanco, Gustavo

“…Renal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown,…”
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