Search Results - "Sáenz, Fabián E."

Genetic diversity and natural selection of Plasmodium vivax reticulocyte invasion genes in Ecuador by Núñez, Andrés, Ntumngia, Francis B, Guerra, Yasel, Adams, John H, Sáenz, Fabián E

“…Knowledge of the diversity of invasion ligands in malaria parasites in endemic regions is essential to understand how natural selection influences genetic…”
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Diverse origin of Plasmodium falciparum in northwest Ecuador by Vera-Arias, Claudia A, Castro, L Enrique, Gómez-Obando, Javier, Sáenz, Fabián E

“…Ecuador plans to eliminate malaria by 2020, and the country has already seen a decrease in the number of cases from more than 100,000 in 2000 to only 618 in…”
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Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis by Carrasquilla, Manuela, Early, Angela M, Taylor, Aimee R, Knudson Ospina, Angélica, Echeverry, Diego F, Anderson, Timothy J C, Mancilla, Elvira, Aponte, Samanda, Cárdenas, Pablo, Buckee, Caroline O, Rayner, Julian C, Sáenz, Fabián E, Neafsey, Daniel E, Corredor, Vladimir

“…The human malaria parasite Plasmodium falciparum is globally widespread, but its prevalence varies significantly between and even within countries. Most…”
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Orally Bioavailable 6‑Chloro-7-methoxy-4(1H)‑quinolones Efficacious against Multiple Stages of Plasmodium by Cross, R. Matthew, Flanigan, David L, Monastyrskyi, Andrii, LaCrue, Alexis N, Sáenz, Fabián E, Maignan, Jordany R, Mutka, Tina S, White, Karen L, Shackleford, David M, Bathurst, Ian, Fronczek, Frank R, Wojtas, Lukasz, Guida, Wayne C, Charman, Susan A, Burrows, Jeremy N, Kyle, Dennis E, Manetsch, Roman

“…The continued proliferation of malaria throughout temperate and tropical regions of the world has promoted a push for more efficacious treatments to combat the…”
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High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy by Vera-Arias, Claudia A, Holzschuh, Aurel, Oduma, Colins O, Badu, Kingsley, Abdul-Hakim, Mutala, Yukich, Joshua, Hetzel, Manuel W, Fakih, Bakar S, Ali, Abdullah, Ferreira, Marcelo U, Ladeia-Andrade, Simone, Sáenz, Fabián E, Afrane, Yaw, Zemene, Endalew, Yewhalaw, Delenasaw, Kazura, James W, Yan, Guiyun, Koepfli, Cristian

“…Most rapid diagnostic tests for Plasmodium falciparum malaria target the Histidine-Rich Proteins 2 and 3 (HRP2 and HRP3). Deletions of the hrp2 and hrp3 genes…”
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4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-Ones Prevent the Transmission of Plasmodium falciparum to Anopheles freeborni by SAENZ, Fabián E, LACRUE, Alexis N, CROSS, R. Matthew, MAIGNAN, Jordany R, UDENZE, Kenneth O, MANETSCH, Roman, KYLE, Dennis E

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Genotypes and phenotypes of resistance in Ecuadorian Plasmodium falciparum by Valenzuela, Gabriela, Castro, L Enrique, Valencia-Zamora, Julio, Vera-Arias, Claudia A, Rohrbach, Petra, Sáenz, Fabián E

“…Malaria continues to be endemic in the coast and Amazon regions of Ecuador. Clarifying current Plasmodium falciparum resistance in the country will support…”
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Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of Plasmodium In Vivo and In Vitro by SAENZ, Fabian E, MUTKA, Tina, UDENZE, Kenneth, ODUOLA, Ayoade M. J, KYLE, Dennis E

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Malaria epidemiology in low-endemicity areas of the northern coast of Ecuador: high prevalence of asymptomatic infections by Sáenz, Fabián E, Arévalo-Cortés, Andrea, Valenzuela, Gabriela, Vallejo, Andrés F, Castellanos, Angélica, Poveda-Loayza, Andrea C, Gutierrez, Juan B, Alvarez, Alvaro, Yan, Yi Heng, Benavides, Yoldy, Castro, Luis Enrique, Arévalo-Herrera, Myriam, Herrera, Sócrates

“…The recent scale-up in malaria control measures in Latin America has resulted in a significant decrease in the number of reported cases in several countries…”
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Clonal population expansion in an outbreak of Plasmodium falciparum on the northwest coast of Ecuador by Sáenz, Fabián E, Morton, Lindsay C, Okoth, Sheila Akinyi, Valenzuela, Gabriela, Vera-Arias, Claudia A, Vélez-Álvarez, Eileen, Lucchi, Naomi W, Castro, L Enrique, Udhayakumar, Venkatachalam

“…Determining the source of malaria outbreaks in Ecuador and identifying remaining transmission foci will help in malaria elimination efforts. In this study, the…”
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4(1H)-Quinolones with Liver Stage Activity against Plasmodium berghei by LACRUE, Alexis N, SAENZ, Fabián E, CROSS, R. Matthew, UDENZE, Kenneth O, MONASTYRSKYI, Andrii, STEIN, Steven, MUTKA, Tina S, MANETSCH, Roman, KYLE, Dennis E

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Bioactivity of synthetic peptides from Ecuadorian frog skin secretions against Leishmania mexicana , Plasmodium falciparum , and Trypanosoma cruzi by Proaño-Bolaños, Carolina, Morán-Marcillo, Giovanna, Espinosa de Los Monteros-Silva, Nina, Bermúdez-Puga, Sebastián, Salazar, Mateo A, Blasco-Zúñiga, Ailín, Cuesta, Sebastián, Molina, Carolina, Espinosa, Franklin, Meneses, Lorena, Rojas-Silva, Patricio, Zapata Mena, Sonia, Sáenz, Fabián E, Rivera I, Miryan, Costales, Jaime A

“…Chagas disease, leishmaniasis, and malaria are major parasitic diseases disproportionately affecting the underprivileged population in developing nations…”
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Evidence for Pyronaridine as a Highly Effective Partner Drug for Treatment of Artemisinin-Resistant Malaria in a Rodent Model by HENRICH, Philipp P, O'BRIEN, Connor, SAENZ, Fabián E, CREMERS, Serge, KYLE, Dennis E, FIDOCK, David A

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The Relative Role of Climate Variation and Control Interventions on Malaria Elimination Efforts in El Oro, Ecuador: A Modeling Study by Fletcher, Isabel K., Stewart-Ibarra, Anna M., Sippy, Rachel, Carrasco-Escobar, Gabriel, Silva, Mercy, Beltran-Ayala, Efrain, Ordoñez, Tania, Adrian, Jefferson, Sáenz, Fabián E., Drakeley, Chris, Jones, Kate E., Lowe, Rachel

“…Malaria is a vector-borne disease of significant public health concern. Despite widespread success of many elimination initiatives, elimination efforts in some…”
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Anopheline and human drivers of malaria risk in northern coastal, Ecuador: a pilot study by Martin, James A, Hendershot, Allison L, Saá Portilla, Iván Alejandro, English, Daniel J, Woodruff, Madeline, Vera-Arias, Claudia A, Salazar-Costa, Bibiana E, Bustillos, Juan José, Saénz, Fabián E, Ocaña-Mayorga, Sofía, Koepfli, Cristian, Lobo, Neil F

“…Understanding local anopheline vector species and their bionomic traits, as well as related human factors, can help combat gaps in protection. In San José de…”
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Molecular epidemiology of continued Plasmodium falciparum disease transmission after an outbreak in Ecuador by Ruybal-Pesántez, Shazia, Sáenz, Fabián E., Deed, Samantha L., Johnson, Erik K., Larremore, Daniel B., Vera-Arias, Claudia A., Tiedje, Kathryn E., Day, Karen P.

“…To better understand the factors underlying the continued incidence of clinical episodes of falciparum malaria in E-2025 countries targeting elimination, we…”
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Targeted disruption of maebl in Plasmodium falciparum by Fu, Jun, Sáenz, Fabián E., Reed, Michael B., Balu, Bharath, Singh, Naresh, Blair, Peter L., Cowman, Alan F., Adams, John H.

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The transmembrane isoform of Plasmodium falciparum MAEBL is essential for the invasion of Anopheles salivary glands by Saenz, Fabian E, Balu, Bharath, Smith, Jonah, Mendonca, Sarita R, Adams, John H

“…Malaria transmission depends on infective stages in the mosquito salivary glands. Plasmodium sporozoites that mature in midgut oocysts must traverse the…”
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Lamina-associated polypeptide 2 (LAP2) expression in fish and amphibians by Del-Pino, Eugenia M, Sáenz, Fabián E, Pérez, Oscar D, Brown, Federico D, Avila, María-Eugenia, Barragán, Verónica A, Haddad, Nisrine, Paulin-Levasseur, Micheline, Krohne, Georg

“…Somatic and germinal cells of 15 fish and 33 amphibian species were examined by SDS-PAGE followed by immunoblotting to determine the expression of LAP2…”
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Quinolone-3-diarylethers: a new class of antimalarial drug by Nilsen, Aaron, LaCrue, Alexis N, White, Karen L, Forquer, Isaac P, Cross, Richard M, Marfurt, Jutta, Mather, Michael W, Delves, Michael J, Shackleford, David M, Saenz, Fabian E, Morrisey, Joanne M, Steuten, Jessica, Mutka, Tina, Li, Yuexin, Wirjanata, Grennady, Ryan, Eileen, Duffy, Sandra, Kelly, Jane Xu, Sebayang, Boni F, Zeeman, Anne-Marie, Noviyanti, Rintis, Sinden, Robert E, Kocken, Clemens H M, Price, Ric N, Avery, Vicky M, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Ferrer, Santiago, Herreros, Esperanza, Sanz, Laura M, Gamo, Francisco-Javier, Bathurst, Ian, Burrows, Jeremy N, Siegl, Peter, Guy, R Kiplin, Winter, Rolf W, Vaidya, Akhil B, Charman, Susan A, Kyle, Dennis E, Manetsch, Roman, Riscoe, Michael K

“…The goal for developing new antimalarial drugs is to find a molecule that can target multiple stages of the parasite's life cycle, thus impacting prevention,…”
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