Search Results - "Rzhetsky, Andrey"

Tradition and Innovation in Scientists' Research Strategies by Foster, Jacob G., Rzhetsky, Andrey, Evans, James A.

“…What factors affect a scientist's choice of research problem? Qualitative research in the history and sociology of science suggests that this choice is…”
Get full text

Classification of common human diseases derived from shared genetic and environmental determinants by Wang, Kanix, Gaitsch, Hallie, Poon, Hoifung, Cox, Nancy J, Rzhetsky, Andrey

“…Andrey Rzhetsky and colleagues analyze electronic medical records from over one-third of the US population to estimate disease heritability and to determine…”
Get full text

Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids by Schuster, Brooke, Junkin, Michael, Kashaf, Sara Saheb, Romero-Calvo, Isabel, Kirby, Kori, Matthews, Jonathan, Weber, Christopher R., Rzhetsky, Andrey, White, Kevin P., Tay, Savaş

“…Three-dimensional (3D) cell culture technologies, such as organoids, are physiologically relevant models for basic and clinical applications. Automated…”
Get full text

Choosing experiments to accelerate collective discovery by Rzhetsky, Andrey, Foster, Jacob G., Foster, Ian T., Evans, James A.

“…A scientist’s choice of research problem affects his or her personal career trajectory. Scientists’ combined choices affect the direction and efficiency of…”
Get full text

Network Properties of Genes Harboring Inherited Disease Mutations by Feldman, Igor, Rzhetsky, Andrey, Vitkup, Dennis

“…By analyzing, in parallel, large literature-derived and high-throughput experimental datasets we investigate genes harboring human inherited disease mutations…”
Get full text

Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark by Khan, Atif, Plana-Ripoll, Oleguer, Antonsen, Sussie, Brandt, Jørgen, Geels, Camilla, Landecker, Hannah, Sullivan, Patrick F, Pedersen, Carsten Bøcker, Rzhetsky, Andrey

“…The search for the genetic factors underlying complex neuropsychiatric disorders has proceeded apace in the past decade. Despite some advances in identifying…”
Get full text

Centralized scientific communities are less likely to generate replicable results by Danchev, Valentin, Rzhetsky, Andrey, Evans, James A

“…Concerns have been expressed about the robustness of experimental findings in several areas of science, but these matters have not been evaluated at scale…”
Get full text

Probing genetic overlap among complex human phenotypes by Rzhetsky, Andrey, Wajngurt, David, Park, Naeun, Zheng, Tian

“…Geneticists and epidemiologists often observe that certain hereditary disorders cooccur in individual patients significantly more (or significantly less)…”
Get full text

OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics by Matthews, Jonathan M, Schuster, Brooke, Kashaf, Sara Saheb, Liu, Ping, Ben-Yishay, Rakefet, Ishay-Ronen, Dana, Izumchenko, Evgeny, Shen, Le, Weber, Christopher R, Bielski, Margaret, Kupfer, Sonia S, Bilgic, Mustafa, Rzhetsky, Andrey, Tay, Savaş

“…Organoids have immense potential as ex vivo disease models for drug discovery and personalized drug screening. Dynamic changes in individual organoid…”
Get full text

Conjunction of factors triggering waves of seasonal influenza by Chattopadhyay, Ishanu, Kiciman, Emre, Elliott, Joshua W, Shaman, Jeffrey L, Rzhetsky, Andrey

“…Using several longitudinal datasets describing putative factors affecting influenza incidence and clinical data on the disease and health status of over 150…”
Get full text

Do psychiatric diseases follow annual cyclic seasonality? by Zhang, Hanxin, Khan, Atif, Chen, Qi, Larsson, Henrik, Rzhetsky, Andrey

“…Seasonal affective disorder (SAD) famously follows annual cycles, with incidence elevation in the fall and spring. Should some version of cyclic annual pattern…”
Get full text

RIDDLE: Race and ethnicity Imputation from Disease history with Deep LEarning by Kim, Ji-Sung, Gao, Xin, Rzhetsky, Andrey

“…Anonymized electronic medical records are an increasingly popular source of research data. However, these datasets often lack race and ethnicity information…”
Get full text

Patchwork of contrasting medication cultures across the USA by Melamed, Rachel D., Rzhetsky, Andrey

“…Health in the United States is markedly heterogeneous, with large disparities in disease incidence, treatment choices and health spending. Drug prescription is…”
Get full text

Measurable health effects associated with the daylight saving time shift by Zhang, Hanxin, Dahlén, Torsten, Khan, Atif, Edgren, Gustaf, Rzhetsky, Andrey

“…The transition to daylight saving time (DST) is beneficial for energy conservation but at the same time it has been reported to increase the risk of…”
Get full text

Prevalence of Common Disease Conditions in a Large Cohort of Individuals With Down Syndrome in the United States by Chicoine, Brian, Rivelli, Anne, Fitzpatrick, Veronica, Chicoine, Laura, Jia, Gengjie, Rzhetsky, Andrey

“…Given the current life expectancy and number of individuals living with Down syndrome (DS), it is important to learn common occurrences of disease conditions…”
Get full text

Observable variations in human sex ratio at birth by Long, Yanan, Chen, Qi, Larsson, Henrik, Rzhetsky, Andrey

“…The human sex ratio at birth (SRB), defined as the ratio between the number of newborn boys to the total number of newborns, is typically slightly greater than…”
Get full text

Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug by Bi, Junfeng, Khan, Atif, Tang, Jun, Armando, Aaron M., Wu, Sihan, Zhang, Wei, Gimple, Ryan C., Reed, Alex, Jing, Hui, Koga, Tomoyuki, Wong, Ivy Tsz-Lo, Gu, Yuchao, Miki, Shunichiro, Yang, Huijun, Prager, Briana, Curtis, Ellis J., Wainwright, Derek A., Furnari, Frank B., Rich, Jeremy N., Cloughesy, Timothy F., Kornblum, Harley I., Quehenberger, Oswald, Rzhetsky, Andrey, Cravatt, Benjamin F., Mischel, Paul S.

“…The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated…”
Get full text

Discerning asthma endotypes through comorbidity mapping by Jia, Gengjie, Zhong, Xue, Im, Hae Kyung, Schoettler, Nathan, Pividori, Milton, Hogarth, D. Kyle, Sperling, Anne I., White, Steven R., Naureckas, Edward T., Lyttle, Christopher S., Terao, Chikashi, Kamatani, Yoichiro, Akiyama, Masato, Matsuda, Koichi, Kubo, Michiaki, Cox, Nancy J., Ober, Carole, Rzhetsky, Andrey, Solway, Julian

“…Asthma is a heterogeneous, complex syndrome, and identifying asthma endotypes has been challenging. We hypothesize that distinct endotypes of asthma arise in…”
Get full text

DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections by Liu, Chun-Chi, Tseng, Yu-Ting, Li, Wenyuan, Wu, Chia-Yu, Mayzus, Ilya, Rzhetsky, Andrey, Sun, Fengzhu, Waterman, Michael, Chen, Jeremy J W, Chaudhary, Preet M, Loscalzo, Joseph, Crandall, Edward, Zhou, Xianghong Jasmine

“…The DiseaseConnect (http://disease-connect.org) is a web server for analysis and visualization of a comprehensive knowledge on mechanism-based disease…”
Get full text

Prevalence of Mental Health Conditions Among 6078 Individuals With Down Syndrome in the United States by Rivelli, Anne, Fitzpatrick, Veronica, Chaudhari, Sagar, Chicoine, Laura, Jia, Gengjie, Rzhetsky, Andrey, Chicoine, Brian

“…Findings from a recent study of the largest documented cohort of individuals with Down syndrome (DS) in the United States described prevalence of common…”
Get full text