Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation treatment of posttraumatic stress disorder in eating disorders: An open‐label case series

Posttraumatic stress disorder (PTSD) is a common comorbid condition in anorexia nervosa (AN) and bulimia nervosa (BN), and may be associated with reduced response to treatment. We report on a case series employing repetitive transcranial magnetic stimulation (rTMS) with a novel target, the dorsomedi...

Full description

Saved in:

Bibliographic Details
Published in:	The International journal of eating disorders Vol. 50; no. 10; pp. 1231 - 1234
Main Authors:	Woodside, D. Blake, Colton, Patricia, Lam, Eileen, Dunlop, Katharine, Rzeszutek, Julia, Downar, Jonathan
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-10-2017
Subjects:	Adult Anorexia Brain Bulimia Comorbidity Eating disorders Feeding and Eating Disorders - diagnostic imaging Female Humans Male Post traumatic stress disorder Prefrontal Cortex - anatomy & histology PTSD rTMS Stress Disorders, Post-Traumatic - diagnostic imaging Stress Disorders, Post-Traumatic - therapy Transcranial magnetic stimulation Transcranial Magnetic Stimulation - methods treatment Treatment Outcome PTSD treatment rTMS
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Posttraumatic stress disorder (PTSD) is a common comorbid condition in anorexia nervosa (AN) and bulimia nervosa (BN), and may be associated with reduced response to treatment. We report on a case series employing repetitive transcranial magnetic stimulation (rTMS) with a novel target, the dorsomedial prefrontal cortex (DMPFC). Fourteen subjects with eating disorders and comorbid PTSD received 20–30 neuronavigated DMPFC–rTMS treatments on an open‐label basis. PTSD symptoms were assessed pretreatment and posttreatment with the PTSD checklist‐Civilian (PCL‐C) and the Difficulties in Emotional Regulation Scale (DERS). PCL‐C scores were reduced by 51.99% ± 27.24% overall, from a mean of 54.29 ± 19.34 pretreatment to 24.86 ± 17.43 posttreatment (p < .001). Of the 14, 8 showed an improvement of >50%. DERS scores improved by 36.02% ± 24.24% overall, from 140.00 ± 22.09 at pretreatment to 89.29 ± 38.31 at posttreatment (p < .001). OF the 14 subjects, 5 achieved >50% improvement. These data may suggest that DMPFC–rTMS could be helpful in the treatment of PTSD in some ED patients.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0276-3478 1098-108X
DOI:	10.1002/eat.22764