Search Results - "Rzepka, Robert W"

Quantitative multiplex sequence analysis of mutational hot spots. Frequency and specificity of mutations induced by a site-specific ethenocytosine in M13 viral DNA by Palejwala, Vaseem A, Rzepka, Robert W, Simha, Devendranath, Humayun, M. Zafri

“…We describe an assay for determining the frequency and specificity of mutations occurring at hot spots within a population of DNA molecules. The procedure…”
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UV irradiation of Escherichia coli modulates mutagenesis at a site-specific ethenocytosine residue on M13 DNA. Evidence for an inducible recA-independent effect by Palejwala, Vaseem A, Rzepka, Robert W, Humayun, M. Zafri

“…Mutagenic action of chemical and physical mutagens is mediated through DNA damage and subsequent misreplication at sites of unrepaired damage. Most DNA damage…”
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NF-IL6, a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene promoter by Combates, N J, Rzepka, R W, Chen, Y N, Cohen, D

“…Revealing the regulatory mechanisms involved in P-glycoprotein expression is important to our understanding of multidrug resistance (MDR) in tumor cells. The…”
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Analysis of the interactions of SDZ PSC 833 ([3'-keto-Bmt1]-Val2]-Cyclosporine), a multidrug resistance modulator, with P-glycoprotein by Archinal-Mattheis, A, Rzepka, R W, Watanabe, T, Kokubu, N, Itoh, Y, Combates, N J, Bair, K W, Cohen, D

“…Multidrug resistance (MDR) is considered to be an important impediment to the effective treatment of cancer. P-glycoprotein, the drug efflux pump that mediates…”
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Involvement of the transcription factor NF-IL6 in phorbol ester induction of P-glycoprotein in U937 cells by COMBATES, N. J, KWON, P. O, RZEPKA, R. W, COHEN, D

“…Previously, we showed that the nuclear factor NF-IL6 binds and trans-activates the promoter of the human multidrug resistance gene (MDR1) encoding…”
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Base incorporation and extension at a site-specific ethenocytosine by Escherichia coli DNA polymerase I Klenow fragment by Simha, D, Yadav, D, Rzepka, R W, Palejwala, V A, Humayun, M Z

“…Ethenocytosine (epsilon C) is a highly mutagenic exocyclic DNA lesion induced by carcinogens vinyl chloride and urethane. We have examined base incorporation…”
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