Search Results - "Rzemieniec, Joanna"
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Cerebral derailment after myocardial infarct: mechanisms and effects of the signaling from the ischemic heart to brain
Published in Journal of molecular medicine (Berlin, Germany) (01-01-2022)“…Myocardial infarction (MI) is the leading cause of death among ischemic heart diseases and is associated with several long-term cardiovascular complications,…”
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Montelukast, an available and safe anti-asthmatic drug, prevents maladaptive remodelling and maintains cardiac functionality following myocardial infarction
Published in Scientific reports (09-02-2024)“…Preclinical and clinical data indicate that the 5-lipoxygenase pathway becomes activated in cardiovascular diseases suggesting an important role of CysLTs in…”
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Nuclear Receptors in Myocardial and Cerebral Ischemia-Mechanisms of Action and Therapeutic Strategies
Published in International journal of molecular sciences (15-11-2021)“…Nearly 18 million people died from cardiovascular diseases in 2019, of these 85% were due to heart attack and stroke. The available therapies although…”
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Prenatal Exposure to Triclocarban Impairs ESR1 Signaling and Disrupts Epigenetic Status in Sex-Specific Ways as Well as Dysregulates the Expression of Neurogenesis- and Neurotransmitter-Related Genes in the Postnatal Mouse Brain
Published in International journal of molecular sciences (04-12-2021)“…Triclocarban is a highly effective and broadly used antimicrobial agent. Humans are continually exposed to triclocarban, but the safety of prenatal exposure to…”
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Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells
Published in Molecular neurobiology (01-06-2018)Get full text
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Effects of exposure to 5-MeO-DIPT during adolescence on brain neurotransmission and neurotoxicity in adult rats
Published in Forensic toxicology (01-01-2019)“…Purpose Tryptamine hallucinogen 5-methoxy- N,N -diisopropyltryptamine (5-MeO-DIPT) is a serotonin transporter inhibitor with high affinity for serotonin 5-HT…”
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Neuroprotective action of daidzein: a crucial role of G-protein coupled receptor 30
Published in Pharmacological reports (01-03-2012)Get full text
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Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons
Published in The Journal of steroid biochemistry and molecular biology (01-09-2018)“…[Display omitted] •Prenatal exposure to BP-3 induces apoptosis in neocortical neurons of offspring.•BP-3 decreases ESR1/ESR2 expression and increases GPER1…”
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Fenofibrate reduces cardiac remodeling by mitochondrial dynamics preservation in a renovascular model of cardiac hypertrophy
Published in European journal of pharmacology (05-09-2024)“…Fenofibrate, a PPAR-α agonist clinically used to lower serum lipid levels, reduces cardiac remodeling and improves cardiac function. However, its mechanism of…”
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Prenatal Exposure to Benzophenone-3 Impairs Autophagy, Disrupts RXRs/PPARγ Signaling, and Alters Epigenetic and Post-Translational Statuses in Brain Neurons
Published in Molecular neurobiology (01-07-2019)“…The UV absorber benzophenone-3 (BP-3) is the most extensively used chemical substance in various personal care products. Despite that BP-3 exposure is…”
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Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells
Published in Molecular neurobiology (01-06-2018)“…Benzophenone-3 (BP-3) is the most widely used compound among UV filters for the prevention of photodegradation. Population studies have demonstrated that it…”
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Selective Targeting of Non-nuclear Estrogen Receptors with PaPE-1 as a New Treatment Strategy for Alzheimer’s Disease
Published in Neurotoxicity research (01-12-2020)“…Alzheimer’s disease (AD) is a multifactorial and severe neurodegenerative disorder characterized by progressive memory decline, the presence of Aβ plaques and…”
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Triclosan-Evoked Neurotoxicity Involves NMDAR Subunits with the Specific Role of GluN2A in Caspase-3-Dependent Apoptosis
Published in Molecular neurobiology (01-01-2019)“…Triclosan (TCS) is an antimicrobial agent that is used extensively in personal care and in sanitising products. A number of studies have shown the presence of…”
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Autophagy-related neurotoxicity is mediated via AHR and CAR in mouse neurons exposed to DDE
Published in The Science of the total environment (10-11-2020)“…DDE (dichlorodiphenyldichloroethylene) is an environmental metabolite of the pesticide DDT, which is still present in the environment, and its insecticidal…”
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Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke
Published in Journal of cerebral blood flow and metabolism (01-07-2023)“…Multicentre preclinical randomized controlled trials (pRCTs) are a valuable tool to improve experimental stroke research, but are challenging and therefore…”
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Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling
Published in The Journal of steroid biochemistry and molecular biology (01-07-2017)“…•Prenatal exposures to DDT induce depressive-like behavior in adolescent mice.•DDT accumulates in mouse brain and leads to global DNA hypomethylation.•p,p’-DDT…”
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The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats
Published in Neurotoxicity research (01-10-2018)“…According to the European Drug Report ( 2016 ), the use of synthetic cathinones, such as mephedrone, among young people has rapidly increased in the last…”
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Correction to: the Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats
Published in Neurotoxicity research (01-07-2019)“…Acknowledgments: This study was supported by the Grant No 2013/09/B/NZ7/04104 from the National Science Center (Poland)…”
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Multicentre translational Trial of Remote Ischaemic Conditioning in Acute Ischaemic Stroke (TRICS): protocol of multicentre, parallel group, randomised, preclinical trial in female and male rat and mouse from the Italian Stroke Organization (ISO) Basic Science network
Published in BMJ open science (24-11-2020)“…IntroductionMulticentre preclinical randomised controlled trials (pRCT) are emerging as a necessary step to confirm efficacy and improve translation into the…”
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