Search Results - "Rzechorzek, Neil J."

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1 by Rzechorzek, Neil J., Kunzelmann, Simone, Purkiss, Andrew G., Silva Dos Santos, Mariana, MacRae, James I., Taylor, Ian A., Fugger, Kasper, West, Stephen C.

“…Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA -deficient breast, ovarian and prostate cancers. As their efficacy is…”
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Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex—Implications for Clamp Loading and Regulation by Doré, Andrew S., Kilkenny, Mairi L., Rzechorzek, Neil J., Pearl, Laurence H.

“…Rad9, Rad1, and Hus1 form a heterotrimeric complex (9-1-1) that is loaded onto DNA at sites of DNA damage. DNA-loaded 9-1-1 activates signaling through the…”
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End-resection at DNA double-strand breaks in the three domains of life by Blackwood, John K, Rzechorzek, Neil J, Bray, Sian M, Maman, Joseph D, Pellegrini, Luca, Robinson, Nicholas P

“…During DNA repair by HR (homologous recombination), the ends of a DNA DSB (double-strand break) must be resected to generate single-stranded tails, which are…”
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CryoEM structures of human CMG–ATPγS–DNA and CMG–AND-1 complexes by Rzechorzek, Neil J, Hardwick, Steven W, Jatikusumo, Vincentius A, Chirgadze, Dimitri Y, Pellegrini, Luca

“…Abstract DNA unwinding in eukaryotic replication is performed by the Cdc45–MCM–GINS (CMG) helicase. Although the CMG architecture has been elucidated, its…”
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Structural basis for the interaction of SARS‐CoV‐2 virulence factor nsp1 with DNA polymerase α–primase by Kilkenny, Mairi L., Veale, Charlotte E., Guppy, Amir, Hardwick, Steven W., Chirgadze, Dimitri Y., Rzechorzek, Neil J., Maman, Joseph D., Pellegrini, Luca

“…The molecular mechanisms that drive the infection by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)—the causative agent of coronavirus…”
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Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine by Holzer, Sandro, Rzechorzek, Neil J, Short, Isobel R, Jenkyn-Bedford, Michael, Pellegrini, Luca, Kilkenny, Mairi L

“…Nucleoside analogues are widely used in clinical practice as chemotherapy drugs. Arabinose nucleoside derivatives such as fludarabine are effective in the…”
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Structure of the hexameric HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea by Rzechorzek, Neil J., Blackwood, John K., Bray, Sian M., Maman, Joseph D., Pellegrini, Luca, Robinson, Nicholas P.

“…The HerA ATPase cooperates with the NurA nuclease and the Mre11–Rad50 complex for the repair of double-strand DNA breaks in thermophilic archaea. Here we…”
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Structural Characterization of Spo0E-like Protein-aspartic Acid Phosphatases That Regulate Sporulation in Bacilli by Grenha, Rosa, Rzechorzek, Neil J., Brannigan, James A., de Jong, Rob N., AB, Eiso, Diercks, Tammo, Truffault, Vincent, Ladds, Joanne C., Fogg, Mark J., Bongiorni, Cristina, Perego, Marta, Kaptein, Robert, Wilson, Keith S., Folkers, Gert E., Wilkinson, Anthony J.

“…Spore formation is an extreme response of many bacterial species to starvation. In the case of pathogenic species of Bacillus and Clostridium, it is also a…”
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Structural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complex by Blackwood, John K, Rzechorzek, Neil J, Abrams, Andrew S, Maman, Joseph D, Pellegrini, Luca, Robinson, Nicholas P

“…Helicase-nuclease systems dedicated to DNA end resection in preparation for homologous recombination (HR) are present in all kingdoms of life. In thermophilic…”
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CtIP tetramer assembly is required for DNA-end resection and repair by Davies, Owen R, Forment, Josep V, Sun, Meidai, Belotserkovskaya, Rimma, Coates, Julia, Galanty, Yaron, Demir, Mukerrem, Morton, Christopher R, Rzechorzek, Neil J, Jackson, Stephen P, Pellegrini, Luca

“…CtIP helps maintain genomic stability by promoting DNA double-strand-break repair. Structural and biophysical analyses now show that the N terminus of human…”
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The structure of the genomic Bacillus subtilis dUTPase: novel features in the Phe-lid by García-Nafría, Javier, Burchell, Lynn, Takezawa, Mine, Rzechorzek, Neil J., Fogg, Mark J., Wilson, Keith S.

“…dUTPases are a ubiquitous family of enzymes that are essential for all organisms and catalyse the breakdown of 2‐deoxyuridine triphosphate (dUTP). In Bacillus…”
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