Search Results - "Ryu, Steven C."

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids by Srikanth, Priya, Lagomarsino, Valentina N., Muratore, Christina R., Ryu, Steven C., He, Amy, Taylor, Walter M., Zhou, Constance, Arellano, Marlise, Young-Pearse, Tracy L.

“…The development of three-dimensional culture methods has allowed for the study of developing cortical morphology in human cells. This provides a new tool to…”
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Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome by Evrony, Gilad D, Cordero, Dwight R, Shen, Jun, Partlow, Jennifer N, Yu, Timothy W, Rodin, Rachel E, Hill, R Sean, Coulter, Michael E, Lam, Anh-Thu N, Jayaraman, Divya, Gerrelli, Dianne, Diaz, Diana G, Santos, Chloe, Morrison, Victoria, Galli, Antonella, Tschulena, Ulrich, Wiemann, Stefan, Martel, M Jocelyne, Spooner, Betty, Ryu, Steven C, Elhosary, Princess C, Richardson, Jillian M, Tierney, Danielle, Robinson, Christopher A, Chibbar, Rajni, Diudea, Dana, Folkerth, Rebecca, Wiebe, Sheldon, Barkovich, A James, Mochida, Ganeshwaran H, Irvine, James, Lemire, Edmond G, Blakley, Patricia, Walsh, Christopher A

“…While next-generation sequencing has accelerated the discovery of human disease genes, progress has been largely limited to the "low hanging fruit" of…”
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Aging and neurodegeneration are associated with increased mutations in single human neurons by Lodato, Michael A, Rodin, Rachel E, Bohrson, Craig L, Coulter, Michael E, Barton, Alison R, Kwon, Minseok, Sherman, Maxwell A, Vitzthum, Carl M, Luquette, Lovelace J, Yandava, Chandri N, Yang, Pengwei, Chittenden, Thomas W, Hatem, Nicole E, Ryu, Steven C, Woodworth, Mollie B, Park, Peter J, Walsh, Christopher A

“…It has long been hypothesized that aging and neurodegeneration are associated with somatic mutation in neurons; however, methodological hurdles have prevented…”
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Somatic genomic changes in single Alzheimer’s disease neurons by Miller, Michael B., Huang, August Yue, Kim, Junho, Zhou, Zinan, Kirkham, Samantha L., Maury, Eduardo A., Ziegenfuss, Jennifer S., Reed, Hannah C., Neil, Jennifer E., Rento, Lariza, Ryu, Steven C., Ma, Chanthia C., Luquette, Lovelace J., Ames, Heather M., Oakley, Derek H., Frosch, Matthew P., Hyman, Bradley T., Lodato, Michael A., Lee, Eunjung Alice, Walsh, Christopher A.

“…Dementia in Alzheimer’s disease progresses alongside neurodegeneration 1 – 4 , but the specific events that cause neuronal dysfunction and death remain poorly…”
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Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size by Johnson, Matthew B., Sun, Xingshen, Kodani, Andrew, Borges-Monroy, Rebeca, Girskis, Kelly M., Ryu, Steven C., Wang, Peter P., Patel, Komal, Gonzalez, Dilenny M., Woo, Yu Mi, Yan, Ziying, Liang, Bo, Smith, Richard S., Chatterjee, Manavi, Coman, Daniel, Papademetris, Xenophon, Staib, Lawrence H., Hyder, Fahmeed, Mandeville, Joseph B., Grant, P. Ellen, Im, Kiho, Kwak, Hojoong, Engelhardt, John F., Walsh, Christopher A., Bae, Byoung-Il

“…The human cerebral cortex is distinguished by its large size and abundant gyrification, or folding. However, the evolutionary mechanisms that drive cortical…”
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