Search Results - "Ryu, Jennifer Hyoje"

Generation of hypoimmunogenic human pluripotent stem cells by Han, Xiao, Wang, Mengning, Duan, Songwei, Franco, Paul J., Kenty, Jennifer Hyoje-Ryu, Hedrick, Preston, Xia, Yulei, Allen, Alana, Ferreira, Leonardo M. R., Strominger, Jack L., Melton, Douglas A., Meissner, Torsten B., Cowan, Chad A.

“…Polymorphic HLAs form the primary immune barrier to cell therapy. In addition, innate immune surveillance impacts cell engraftment, yet a strategy to control…”
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A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure by Baron, Maayan, Veres, Adrian, Wolock, Samuel L, Faust, Aubrey L, Gaujoux, Renaud, Vetere, Amedeo, Ryu, Jennifer Hyoje, Wagner, Bridget K, Shen-Orr, Shai S, Klein, Allon M, Melton, Douglas A, Yanai, Itai

“…Although the function of the mammalian pancreas hinges on complex interactions of distinct cell types, gene expression profiles have primarily been described…”
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Retrieval and purification of human β cells from stem cell-derived islet engrafted mice by Kenty, Jennifer Hyoje-Ryu, Pelayo, Gabriela Cristina, Leite, Nayara Carvalho

“…Stem cell-derived beta cells (SC-β-cells) engrafted into mice serve as a pre-clinical model of diabetes. It is helpful to recover viable β cells following…”
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Generation of a heterozygous GAPDH-Luciferase human ESC line (HVRDe008-A-1) for in vivo monitoring of stem cells and their differentiated progeny by Gerace, Dario, Boulanger, Kyle R., Hyoje-Ryu Kenty, Jennifer, Melton, Douglas A.

“…Human stem cell-derived beta (SC-β) cells are a candidate for cell replacement therapy for type 1 diabetes. Whilst refinements to the differentiation protocol…”
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Charting cellular identity during human in vitro β-cell differentiation by Veres, Adrian, Faust, Aubrey L., Bushnell, Henry L., Engquist, Elise N., Kenty, Jennifer Hyoje-Ryu, Harb, George, Poh, Yeh-Chuin, Sintov, Elad, Gürtler, Mads, Pagliuca, Felicia W., Peterson, Quinn P., Melton, Douglas A.

“…In vitro differentiation of human stem cells can produce pancreatic β-cells; the loss of this insulin-secreting cell type underlies type 1 diabetes. Here, as a…”
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Generation of Functional Human Pancreatic β Cells In Vitro by Pagliuca, Felicia W., Millman, Jeffrey R., Gürtler, Mads, Segel, Michael, Van Dervort, Alana, Ryu, Jennifer Hyoje, Peterson, Quinn P., Greiner, Dale, Melton, Douglas A.

“…The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide an unprecedented cell source for drug discovery and cell…”
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Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance by Gerace, Dario, Zhou, Quan, Kenty, Jennifer Hyoje-Ryu, Veres, Adrian, Sintov, Elad, Wang, Xi, Boulanger, Kyle R., Li, Hongfei, Melton, Douglas A.

“…Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be achieved without chronic immunosuppression or encapsulation…”
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Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication by Annes, Justin P, Ryu, Jennifer Hyoje, Lam, Kelvin, Carolan, Peter J, Utz, Katrina, Hollister-Lock, Jennifer, Arvanites, Anthony C, Rubin, Lee L, Weir, Gordon, Melton, Douglas A

“…Diabetes is a pathological condition characterized by relative insulin deficiency, persistent hyperglycemia, and, consequently, diffuse micro- and…”
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Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets by Sintov, Elad, Nikolskiy, Igor, Barrera, Victor, Hyoje-Ryu Kenty, Jennifer, Atkin, Alexander S., Gerace, Dario, Ho Sui, Shannan J., Boulanger, Kyle, Melton, Douglas A.

“…Human embryonic stem cells (hESCs) provide opportunities for cell replacement therapy of insulin-dependent diabetes. Therapeutic quantities of human stem…”
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Charting cellular identity during human in vitro [beta]-cell differentiation by Veres, Adrian, Faust, Aubrey L, Bushnell, Henry L, Engquist, Elise N, Kenty, Jennifer Hyoje-Ryu, Harb, George, Poh, Yeh-Chuin

“…In vitro differentiation of human stem cells can produce pancreatic [beta]-cells; the loss of this insulin-secreting cell type underlies type 1 diabetes. Here,…”
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Repurposing cAMP-Modulating Medications to Promote β-Cell Replication by Zhao, Zhenshan, Low, Yen S, Armstrong, Neali A, Ryu, Jennifer Hyoje, Sun, Sara A, Arvanites, Anthony C, Hollister-Lock, Jennifer, Shah, Nigam H, Weir, Gordon C, Annes, Justin P

“…Loss of β-cell mass is a cardinal feature of diabetes. Consequently, developing medications to promote β-cell regeneration is a priority. cAMP is an…”
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Adenosine kinase inhibition selectively promotes rodent and porcine islet [Beta]-cell replication by Annes, Justin P, Ryu, Jennifer Hyoje, Lam, Kelvin, Carolan, Peter J, Utz, Katrina, Hollister-Lock, Jennifer, Arvanites, Anthony C, Rubin, Lee L, Weir, Gordon, Melton, Douglas A

“…Diabetes is a pathological condition characterized by relative insulin deficiency, persistent hyperglycemia, and, consequently, diffuse micro- and…”
Get full text