Search Results - "Rytkonen, T."

Glycolysis and Heavy Menstrual Bleeding by Rytkönen, Kalle T

“…Menstrual cycle is a major determinant in female reproductive health. In a recent report, Mao et al. (2022) associated deficient glycolysis with heavy…”
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Oxygen and early animals by Rytkönen, Kalle T

“…The biology of sponges provides clues about how early animals may have dealt with low levels of oxygen…”
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Disruption of HSD17B12 in mouse hepatocytes leads to reduced body weight and defect in the lipid droplet expansion associated with microvesicular steatosis by Heikelä, Hanna, Mairinoja, Laura, Ruohonen, Suvi T., Rytkönen, Kalle T., Brot, Simone, Laiho, Asta, Koskinen, Satu, Suomi, Tomi, Elo, Laura L., Strauss, Leena, Poutanen, Matti

“…The function of hydroxysteroid dehydrogenase 12 (HSD17B12) in lipid metabolism is poorly understood. To study this further, we created mice with…”
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Decidualization of Human Endometrial Stromal Fibroblasts is a Multiphasic Process Involving Distinct Transcriptional Programs by Rytkönen, Kalle T, Erkenbrack, Eric M, Poutanen, Matti, Elo, Laura L, Pavlicev, Mihaela, Wagner, Günter P

“…Decidual stromal cells differentiate from endometrial stromal fibroblasts (ESFs) under the influence of progesterone and cyclic adenosine monophosphate (cAMP)…”
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Functional genomics in aquatic toxicology—Do not forget the function by Nikinmaa, Mikko, Rytkönen, Kalle T.

“…Toxicological responses of an organism are disturbances of function. This as a starting point we review and discuss issues that we consider important in…”
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Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells by Rytkönen, Kalle T, Adossa, Nigatu, Zúñiga Norman, Sebastián, Lönnberg, Tapio, Poutanen, Matti, Elo, Laura L

“…Human reproductive success relies on the proper differentiation of the uterine endometrium to facilitate implantation, formation of the placenta, and…”
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Developmental transcription of genes putatively associated with growth in two sturgeon species of different growth rate by Miandare, Hamed Kolangi, Farahmand, Hamid, Akbarzadeh, Arash, Ramezanpour, Sanaz, Kaiya, Hiroyuki, Miyazato, Mikiya, Rytkönen, Kalle T, Nikinmaa, Mikko

“…Highlights ► We studied developmental transcription of gh , igf-I , ghrl and vegf in Beluga and Persian sturgeon. ► In both species, mRNA levels of igf-I and…”
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Revisiting redox-active antioxidant defenses in response to hypoxic challenge in both hypoxia-tolerant and hypoxia-sensitive fish species by Leveelahti, Lotta, Rytkönen, Kalle T, Renshaw, Gillian M. C, Nikinmaa, Mikko

“…It is not known whether changes in antioxidant levels always occur in fish in response to the oxidative stress that usually accompanies a hypoxic challenge…”
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SUBFUNCTIONALIZATION OF CYPRINID HYPOXIA-INDUCIBLE FACTORS FOR ROLES IN DEVELOPMENT AND OXYGEN SENSING by Rytkönen, Kalle T., Akbarzadeh, Arash, Miandare, Hamed K., Kamei, Hiroyasu, Duan, Cunming, Leder, Erica H., Williams, Tom A., Nikinmaa, Mikko

“…Among vertebrates, teleost fishes have evolved the most impressive adaptations to variable oxygen tensions in water (Shoubridge and Hochachka 1980; Nilsson and…”
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Differential ATAC-seq and ChIP-seq peak detection using ROTS by Faux, Thomas, Rytkönen, Kalle T, Mahmoudian, Mehrad, Paulin, Niklas, Junttila, Sini, Laiho, Asta, Elo, Laura L

“…Abstract Changes in cellular chromatin states fine-tune transcriptional output and ultimately lead to phenotypic changes. Here we propose a novel application…”
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Transcriptional responses to hypoxia are enhanced by recurrent hypoxia (hypoxic preconditioning) in the epaulette shark by Rytkönen, Kalle T, Renshaw, Gillian M C, Vainio, Petra P, Ashton, Kevin J, Williams-Pritchard, Grant, Leder, Erica H, Nikinmaa, Mikko

“…All animals require molecular oxygen for aerobic energy production, and oxygen availability has played a particularly important role in the evolution of…”
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From genomes to functions in aquatic biology by Nikinmaa, Mikko, Rytkönen, Kalle T.

“…In this paper we evaluate factors which should, in our opinion, be taken into account when genomic studies in aquatic organisms are extended to functions. Our…”
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From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia by Hoogewijs, D., Terwilliger, N. B., Webster, K. A., Powell-Coffman, J. A., Tokishita, S., Yamagata, H., Hankeln, T., Burmester, T., Rytkönen, K. T., Nikinmaa, M., Abele, D., Heise, K., Lucassen, M., Fandrey, J., Maxwell, P. H., Påhlman, S., Gorr, T. A.

“…The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists…”
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Molecular evolution of the metazoan PHD-HIF oxygen-sensing system by Rytkönen, Kalle T, Williams, Tom A, Renshaw, Gillian M, Primmer, Craig R, Nikinmaa, Mikko

“…Metazoans rely on aerobic energy production, which requires an adequate oxygen supply. During reduced oxygen supply (hypoxia), the most profound changes in…”
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Computational strategies for single-cell multi-omics integration by Adossa, Nigatu, Khan, Sofia, Rytkönen, Kalle T., Elo, Laura L.

“…Single-cell omics technologies are currently solving biological and medical problems that earlier have remained elusive, such as discovery of new cell types,…”
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Comparison of hypoxia-inducible factor-1 alpha in hypoxia-sensitive and hypoxia-tolerant fish species by Rytkönen, Kalle T., Vuori, Kristiina A.M., Primmer, Craig R., Nikinmaa, Mikko

“…Levels of oxygen can vary dramatically in aquatic environments. Aquatic organisms, including fishes, have adapted accordingly to survive. As there are both…”
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Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice by Heinosalo, Taija, Rytkönen, Kalle T, Saarinen, Niina, Järvensivu, Päivi, Damdimopoulou, Pauliina, Strauss, Leena, Orasniemi, Satu, Horshauge, Petricia, Gabriel, Michael, Koskimies, Pasi, Ohlsson, Claes, Kronqvist, Pauliina, Poutanen, Matti

“…Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is an enzyme that converts estrone to estradiol, while adenomyosis is an estrogen-dependent disease with…”
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COVID-19-specific transcriptomic signature detectable in blood across multiple cohorts by Välikangas, Tommi, Junttila, Sini, Rytkönen, Kalle T, Kukkonen-Macchi, Anu, Suomi, Tomi, Elo, Laura L

“…The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading across the world despite vast…”
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Transcriptional divergence of the duplicated hypoxia-inducible factor alpha genes in zebrafish by Rytkönen, Kalle T., Prokkola, Jenni M., Salonen, Virpi, Nikinmaa, Mikko

“…Oxygen availability has been a major force in shaping the physiological evolution of animals. Under reduced oxygen availability (hypoxia) major changes in gene…”
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Elasmobranch qPCR reference genes: a case study of hypoxia preconditioned epaulette sharks by Rytkönen, Kalle T, Renshaw, Gillian M C, Ashton, Kevin J, Williams-Pritchard, Grant, Leder, Erica H, Nikinmaa, Mikko

“…Elasmobranch fishes are an ancient group of vertebrates which have high potential as model species for research into evolutionary physiology and genomics…”
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