Search Results - "Ryter, Stefan"

Heme oxygenase-1/carbon monoxide as modulators of autophagy and inflammation by Ryter, Stefan W.

“…Heme oxygenase-1 (HO-1) catalyzes heme degradation to generate biliverdin-IXα, carbon monoxide (CO), and iron. The HO-1/CO system confers cytoprotection in…”
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Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders by Ryter, Stefan W

“…The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO), ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR)…”
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Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation by Ryter, Stefan W

“…Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate biliverdin, carbon monoxide (CO), and iron. The inducible form of the…”
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Pathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis by Moss, Benjamin J, Ryter, Stefan W, Rosas, Ivan O

“…The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell types and signaling pathways. Recurrent alveolar epithelial cell…”
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Mitochondria in health, disease, and aging by Harrington, John S, Ryter, Stefan W, Plataki, Maria, Price, David R, Choi, Augustine M K

“…Mitochondria are well known as organelles responsible for the maintenance of cellular bioenergetics through the production of ATP. Although oxidative…”
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Therapeutic Potential of Heme Oxygenase-1 and Carbon Monoxide in Acute Organ Injury, Critical Illness, and Inflammatory Disorders by Ryter, Stefan

“…Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the…”
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Targeting AMPK and the Nrf2/HO-1 axis: a promising therapeutic strategy in acute lung injury by Ryter, Stefan W

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Significance of Heme and Heme Degradation in the Pathogenesis of Acute Lung and Inflammatory Disorders by Ryter, Stefan W.

“…The heme molecule serves as an essential prosthetic group for oxygen transport and storage proteins, as well for cellular metabolic enzyme activities,…”
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Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease by Ryter, Stefan W, Bhatia, Divya, Choi, Mary E

“…Autophagy, a lysosome-dependent homeostatic process inherent to cells and tissues, has emerging significance in the pathogenesis of human disease. This process…”
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Autophagy in Human Health and Disease by Doria, Andrea, Gatto, Mariele, Punzi, Leonardo, Choi, Augustine M.K, Ryter, Stefan W, Levine, Beth

“…To the Editor: Choi et al. (Feb. 14 issue) 1 describe autophagy activation in several human diseases. However, a worthy point was missed, since autophagic…”
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Oxidative stress and autophagy: crucial modulators of kidney injury by Sureshbabu, Angara, Ryter, Stefan W, Choi, Mary E

“…Both acute kidney injury (AKI) and chronic kidney disease (CKD) that lead to diminished kidney function are interdependent risk factors for increased…”
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mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation by Moon, Jong-Seok, Hisata, Shu, Park, Mi-Ae, DeNicola, Gina M, Ryter, Stefan W, Nakahira, Kiichi, Choi, Augustine M K

“…The mammalian target of rapamycin complex 1 (mTORC1) regulates activation of immune cells and cellular energy metabolism. Although glycolysis has been linked…”
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Carbon monoxide in lung cell physiology and disease by Ryter, Stefan W, Ma, Kevin C, Choi, Augustine M K

“…Carbon monoxide (CO) is an endogenously produced gas that has gained recognition as a biological signal transduction effector with properties similar, but not…”
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Autophagy: A critical regulator of cellular metabolism and homeostasis by Ryter, Stefan W., Cloonan, Suzanne M., Choi, Augustine M. K.

“…Autophagy is a dynamic process by which cytosolic material, including organelles, proteins, and pathogens, are sequestered into membrane vesicles called…”
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Necroptosis: a crucial pathogenic mediator of human disease by Choi, Mary E, Price, David R, Ryter, Stefan W, Choi, Augustine M K

“…Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an important pathway in human disease. The necroptosis pathway is…”
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NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages by Moon, Jong-Seok, Nakahira, Kiichi, Chung, Kuei-Pin, DeNicola, Gina M, Koo, Michael Jakun, Pabón, Maria A, Rooney, Kristen T, Yoon, Joo-Heon, Ryter, Stefan W, Stout-Delgado, Heather, Choi, Augustine M K

“…Altered metabolism has been implicated in the pathogenesis of inflammatory diseases. NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, has…”
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Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD by Mizumura, Kenji, Cloonan, Suzanne M, Nakahira, Kiichi, Bhashyam, Abhiram R, Cervo, Morgan, Kitada, Tohru, Glass, Kimberly, Owen, Caroline A, Mahmood, Ashfaq, Washko, George R, Hashimoto, Shu, Ryter, Stefan W, Choi, Augustine M K

“…The pathogenesis of chronic obstructive pulmonary disease (COPD) remains unclear, but involves loss of alveolar surface area (emphysema) and airway…”
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Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease by Lee, Seonmin, Suh, Gee-Young, Ryter, Stefan W, Choi, Augustine M K

“…Inflammasomes are specialized inflammatory signaling platforms that govern the maturation and secretion of proinflammatory cytokines, such as IL-1β and IL-18,…”
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Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease by Chen, Zhi-Hua, Kim, Hong Pyo, Sciurba, Frank C, Lee, Seon-Jin, Feghali-Bostwick, Carol, Stolz, Donna B, Dhir, Rajiv, Landreneau, Rodney J, Schuchert, Mathew J, Yousem, Samuel A, Nakahira, Kiichi, Pilewski, Joseph M, Lee, Janet S, Zhang, Yingze, Ryter, Stefan W, Choi, Augustine M K

“…Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue…”
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UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis by Moon, Jong-Seok, Lee, Seonmin, Park, Mi-Ae, Siempos, Ilias I, Haslip, Maria, Lee, Patty J, Yun, Mijin, Kim, Chun K, Howrylak, Judie, Ryter, Stefan W, Nakahira, Kiichi, Choi, Augustine M K

“…Cellular lipid metabolism has been linked to immune responses; however, the precise mechanisms by which de novo fatty acid synthesis can regulate inflammatory…”
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