Search Results - "Ryser, Stefan"

Human antibody repertoire frequently includes antibodies to a bacterial biofilm associated protein by Ryser, Stefan, Tenorio, Edgar, Estellés, Angeles, Kauvar, Lawrence M

“…We have previously described a native human monoclonal antibody, TRL1068, that disrupts bacterial biofilms by extracting from the biofilm matrix key…”
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High affinity anti-TIM-3 and anti-KIR monoclonal antibodies cloned from healthy human individuals by Ryser, Stefan, Estellés, Angeles, Tenorio, Edgar, Kauvar, Lawrence M, Gishizky, Mikhail L

“…We report here the cloning of native high affinity anti-TIM-3 and anti-KIR IgG monoclonal antibodies (mAbs) from peripheral blood mononuclear cells (PBMC) of…”
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Pharmaceutical innovation between scientific opportunities and economic constraints by Drews, Jürgen, Ryser, Stefan

“…New drugs are only developed when sales expectations appear to match the rising expenditures for development. The repertoire of diseases that are seriously…”
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Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip by Conway, Janet, Delanois, Ronald E, Mont, Michael A, Stavrakis, Alexandra, McPherson, Edward, Stolarski, Edward, Incavo, Stephen, Oakes, Daniel, Salvagno, Ralph, Adams, John S, Kisch-Hancock, Adriane, Tenorio, Edgar, Leighton, Anton, Ryser, Stefan, Kauvar, Lawrence M, Bernthal, Nicholas M

“…We report the results of a first-in-human phase 1 clinical study to evaluate TRL1068, a native human monoclonal antibody that disrupts bacterial biofilms with…”
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A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model by Estellés, Angeles, Woischnig, Anne-Kathrin, Liu, Keyi, Stephenson, Robert, Lomongsod, Evelene, Nguyen, Da, Zhang, Jianzhong, Heidecker, Manfred, Yang, Yifan, Simon, Reyna J, Tenorio, Edgar, Ellsworth, Stote, Leighton, Anton, Ryser, Stefan, Gremmelmaier, Nina Khanna, Kauvar, Lawrence M

“…Many serious bacterial infections are difficult to treat due to biofilm formation, which provides physical protection and induces a sessile phenotype…”
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A Human Biofilm-Disrupting Monoclonal Antibody Potentiates Antibiotic Efficacy in Rodent Models of both Staphylococcus aureus and Acinetobacter baumannii Infections by Xiong, Yan Q, Estellés, Angeles, Li, L, Abdelhady, W, Gonzales, R, Bayer, Arnold S, Tenorio, Edgar, Leighton, Anton, Ryser, Stefan, Kauvar, Lawrence M

“…Many serious bacterial infections are antibiotic refractory due to biofilm formation. A key structural component of biofilm is extracellular DNA, which is…”
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Drug approvals and failures: implications for alliances by Czerepak, Elizabeth A, Ryser, Stefan

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Abstract 594: Antibodies targeting LAG-3, TIM-3, KIR cloned from healthy human donors by Estelles, Angeles, Stephenson, Robert, Liu, Keyi, Lomongsod, Evelene, Ngyen, Da, Zhzng, Jianzhong, Yang, Yifan, Heideker, Manfred, Kauvar, Lawrence, Ryser, Stefan, Gishizky, Mikhail L.

“…The immunosurveillance/immunoediting theory postulates that tumor growth is repressed in healthy individuals through the activation of adaptive and innate…”
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The role of innovation in drug development by Drews, J, Ryser, S

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Classic drug targets by Drews, Jürgen, Ryser, Stefan

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Drug Development: The role of innovation in drug development by Drews, Jürgen, Ryser, Stefan

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In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes by Uematsu, Y, Ryser, S, Dembić, Z, Borgulya, P, Krimpenfort, P, Berns, A, von Boehmer, H, Steinmetz, M

“…Transgenic mice were constructed with a functional T cell receptor beta gene. Transcription of the introduced gene is largely confined to T cells, but low…”
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Early Expression of a T-Cell Receptor β -Chain Transgene Suppresses Rearrangement of the Vγ 4 Gene Segment by Von Boehmer, Harald, Bonneville, Marc, Ishida, Isao, Ryser, Stefan, Lincoln, Gloria, Smith, Richard T., Kishi, Hiroyuki, Scott, Bernadette, Kisielow, Pawel, Tonegawa, Susumu

“…β transgenic mice have a T-cell receptor β -chain gene that is prematurely expressed on the surface of CD4- CD8- thymocytes and paired with an uncharacterized…”
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Functional expression of a human TCR beta gene in transgenic mice by Rothe, J, Ryser, S, Mueller, U, Steinmetz, M, Bluethmann, H

“…A functionally rearranged TCR beta (Tcrb) gene was isolated from a cloned human T helper cell recognizing the CS.T3 epitope of Plasmodium falciparum with…”
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Transgenic mice to study T-cell receptor gene regulation and repertoire formation by Steinmetz, M, Blüthmann, H, Ryser, S, Uematsu, Y

“…Transgenic mice have been obtained with genes coding for an alpha beta T-cell receptor that recognizes the male-specific antigen H-Y in association with the Db…”
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