Search Results - "Ryong Moon, Hyung"

Evaluation of Antimelanogenic Activity and Mechanism of Galangin in Silico and in Vivo by Chung, Ki Wung, Jeong, Hyeong Oh, Lee, Eun Kyeong, Kim, Su Jeong, Chun, Pusoon, Chung, Hae Young, Moon, Hyung Ryong

“…Abnormal pigmentation owing to excessive melanin synthesis can result in serious problems such as freckles, age-spots, and melanoma. Tyrosinase inhibitors have…”
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(2 E ,5 E )-2,5-Bis(3-hydroxy-4-methoxybenzylidene) cyclopentanone Exerts Anti-Melanogenesis and Anti-Wrinkle Activities in B16F10 Melanoma and Hs27 Fibroblast Cells by Jung, Hee Jin, Lee, A Kyoung, Park, Yeo Jin, Lee, Sanggwon, Kang, Dongwan, Jung, Young Suk, Chung, Hae Young, Moon, Hyung Ryong

“…Ultraviolet (UV) radiation exposure is the primary cause of extrinsic skin aging, which results in skin hyperpigmentation and wrinkling. In this study, we…”
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A PPAR Pan Agonist, MHY2013 Alleviates Age-Related Hepatic Lipid Accumulation by Promoting Fatty Acid Oxidation and Suppressing Inflammation by An, Hye Jin, Lee, Bonggi, Kim, Seong Min, Kim, Dae Hyun, Chung, Ki Wung, Ha, Su Gyeong, Park, Kyung Chul, Park, Yeo Jin, Kim, Seong Jin, Yun, Hwi Young, Chun, Pusoon, Yu, Byung Pal, Moon, Hyung Ryong, Chung, Hae Young

“…Nonalcoholic fatty liver disease (NAFLD) is frequently observed in obese and aged individuals. Peroxisome proliferator-activated receptors (PPARs) play a role…”
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Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies by Choi, Heejeong, Young Ryu, Il, Choi, Inkyu, Ullah, Sultan, Jin Jung, Hee, Park, Yujin, Hwang, YeJi, Jeong, Yeongmu, Hong, Sojeong, Chun, Pusoon, Young Chung, Hae, Ryong Moon, Hyung

“…[Display omitted] •Of the synthesized 11 DHIT derivatives, three derivatives 1a, 1b and 1c exhibited stronger mushroom tyrosinase inhibition than kojic acid, a…”
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(Z)-2-(Benzo[d]thiazol-2-ylamino)-5-(substituted benzylidene)thiazol-4(5H)-one Derivatives as Novel Tyrosinase Inhibitors by Kang, Kyeong Ha, Lee, Bonggi, Son, Sujin, Yun, Hwi Young, Moon, Kyoung Mi, Jeong, Hyoung Oh, Kim, Dae Hyun, Lee, Eun Kyeong, Choi, Yeon Ja, Kim, Do Hyun, Chun, Pusoon, Moon, Hyung Ryong, Chung, Hae Young

“…Inhibiting tyrosinase is an important goal to prevent melanin accumulation in skin and thereby to inhibit pigmentation disorders. Therefore, tyrosinase…”
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A Novel Synthesized Tyrosinase Inhibitor: (E)-2-((2,4-Dihydroxyphenyl)diazenyl)phenyl 4-Methylbenzenesulfonate as an Azo-Resveratrol Analog by BAE, Sung Jin, HA, Young Mi, KIM, Jin-Ah, PARK, Ji Young, HA, Tae Kwun, PARK, Daeui, CHUN, Pusoon, PARK, Nam Hee, MOON, Hyung Ryong, CHUNG, Hae Young

“…We synthesized a novel series of (E)-2-((substituted phenyl)diazenyl)phenyl 4-methylbenzenesulfonate derivatives (2 and 3) and (E)-2-((substituted…”
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Discovery of a New Nucleoside Template for Human A3 Adenosine Receptor Ligands:  d-4‘-Thioadenosine Derivatives without 4‘-Hydroxymethyl Group as Highly Potent and Selective Antagonists by Jeong, Lak Shin, Choe, Seung Ah, Gunaga, Prashantha, Kim, Hea Ok, Lee, Hyuk Woo, Lee, Sang Kook, Tosh, Dilip K, Patel, Amit, Palaniappan, Krishnan K, Gao, Zhan-Guo, Jacobson, Kenneth A, Moon, Hyung Ryong

“…Truncated d-4‘-thioadenosine derivatives lacking the 4‘-hydroxymethylene moiety were synthesized starting from d-mannose, using cyclization to the 4-thiosugar…”
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Molecular Docking Studies of (1E,3E,5E)-1,6-Bis(substituted phenyl)hexa-1,3,5-triene and 1,4-Bis(substituted trans-styryl)benzene Analogs as Novel Tyrosinase Inhibitors by Ha, Young Mi, Lee, Hye Jin, Park, Daeui, Jeong, Hyoung Oh, Park, Ji Young, Park, Yun Jung, Lee, Kyung Jin, Lee, Ji Yeon, Moon, Hyung Ryong, Chung, Hae Young

“…We simulated the docking of the tertiary structure of mushroom tyrosinase with our compounds. From the structure-tyrosinase inhibitory activity relationship,…”
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Structure−Activity Relationships of Truncated d- and l-4′-Thioadenosine Derivatives as Species-Independent A3 Adenosine Receptor Antagonists by Jeong, Lak Shin, Pal, Shantanu, Choe, Seung Ah, Choi, Won Jun, Jacobson, Kenneth A, Gao, Zhan-Guo, Klutz, Athena M, Hou, Xiyan, Kim, Hea Ok, Lee, Hyuk Woo, Lee, Sang Kook, Tosh, Dilip K, Moon, Hyung Ryong

“…Novel d- and l-4′-thioadenosine derivatives lacking the 4′-hydroxymethyl moiety were synthesized, starting from d-mannose and d-gulonic γ-lactone,…”
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Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process by Ha, Sugyeong, Chung, Ki Wung, Lee, Jaewon, Chung, Hae Young, Moon, Hyung Ryong

“…Renal fibrosis is defined by excessive extracellular matrix (ECM) accumulation and is associated with a decreased kidney function. Increased inflammation and…”
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Colon-targeted delivery of cyclosporine A using dual-functional Eudragit ® FS30D/PLGA nanoparticles ameliorates murine experimental colitis by Naeem, Muhammad, Bae, Junhwan, Oshi, Murtada A, Kim, Min-Soo, Moon, Hyung Ryong, Lee, Bok Luel, Im, Eunok, Jung, Yunjin, Yoo, Jin-Wook

“…Colon-targeted oral nanoparticles (NPs) have emerged as an ideal, safe, and effective therapy for ulcerative colitis (UC) owing to their ability to selectively…”
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A highly efficient synthesis of unnatural l-sugars from d-ribose by Yun, Mikyung, Moon, Hyung Ryong, Kim, Hea Ok, Choi, Won Jun, Kim, Yong-Chul, Park, Chul-Seung, Jeong, Lak Shin

“…A preparative and short synthesis of l-ribose and l-apiose was accomplished starting from d-ribose via stereoselective cis-dihydroxylation and…”
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Thiazol-4(5H)-one analogs as potent tyrosinase inhibitors: Synthesis, tyrosinase inhibition, antimelanogenic effect, antioxidant activity, and in silico docking simulation by Jung Park, Yu, Jin Jung, Hee, Jin Kim, Hye, Soo Park, Hye, Lee, Jieun, Yoon, Dahye, Kyung Kang, Min, Young Kim, Ga, Ullah, Sultan, Kang, Dongwan, Park, Yujin, Chun, Pusoon, Young Chung, Hae, Ryong Moon, Hyung

“…As the β-phenyl-α,β-unsaturated carbonyl (PUSC) structure was previously identified to play a key role in tyrosinase inhibition, 14 analogs with a PUSC…”
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A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation by De, Umasankar, Son, Ji Yeon, Sachan, Richa, Park, Yu Jin, Kang, Dongwan, Yoon, Kyungsil, Lee, Byung Mu, Kim, In Su, Moon, Hyung Ryong, Kim, Hyung Sik

“…We previously discovered a novel sirtuin (SIRT) inhibitor, MHY2256, that exerts anticancer activity through p53 acetylation in MCF-7 human breast cancer cells…”
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Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites by Ju, Zhiran, Su, Mingzhi, Hong, Jongki, La Kim, Eun, Moon, Hyung Ryong, Chung, Hae Young, Kim, Suhkmann, Jung, Jee H.

“…The aim of this study was to design and synthesize COX-1/COX-2 balanced inhibitors incorporating the structural motifs of anti-inflammatory ascidian…”
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Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion by Choi, Yeon Ja, Park, Yun Jung, Park, Ji Young, Jeong, Hyoung Oh, Kim, Dae Hyun, Ha, Young Mi, Kim, Ji Min, Song, Yu Min, Heo, Hyoung-Sam, Yu, Byung Pal, Chun, Pusoon, Moon, Hyung Ryong, Chung, Hae Young

“…Autophagy is a major degradative process responsible for the disposal of cytoplasmic proteins and dysfunctional organelles via the lysosomal pathway. During…”
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Design and Synthesis of ( Z )-2-(Benzylamino)-5-benzylidenethiazol-4(5 H )-one Derivatives as Tyrosinase Inhibitors and Their Anti-Melanogenic and Antioxidant Effects by Lee, Jieun, Park, Yu Jung, Jung, Hee Jin, Ullah, Sultan, Yoon, Dahye, Jeong, Yeongmu, Kim, Ga Young, Kang, Min Kyung, Kang, Dongwan, Park, Yujin, Chun, Pusoon, Chung, Hae Young, Moon, Hyung Ryong

“…In this study, ( )-2-(benzylamino)-5-benzylidenethiazol-4(5 )-one (BABT) derivatives were designed as tyrosinase inhibitors based on the structure of MHY2081,…”
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5-Fluorouracil crystal-incorporated, pH-responsive, and release-modulating PLGA/Eudragit FS hybrid microparticles for local colorectal cancer-targeted chemotherapy by Lee, Juho, Bae, Junhwan, Kwak, Dongmin, Kim, Hyunwoo, Kim, Jihyun, Phyu Hlaing, Shwe, Saparbayeva, Aruzhan, Hee Lee, Eun, Yoon, In-Soo, Kim, Min-Soo, Ryong Moon, Hyung, Yoo, Jin-Wook

“…[Display omitted] 5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent for colorectal cancer (CRC) owing to its potent anticancer effects. However,…”
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Investigation of the Efficacy of Benzylidene-3-methyl-2-thioxothiazolidin-4-one Analogs with Antioxidant Activities on the Inhibition of Mushroom and Mammal Tyrosinases by Kim, Hye Jin, Jung, Hee Jin, Kim, Young Eun, Jeong, Daeun, Park, Hyeon Seo, Park, Hye Soo, Kang, Dongwan, Park, Yujin, Chun, Pusoon, Chung, Hae Young, Moon, Hyung Ryong

“…Based on the fact that substances with a β-phenyl-α,β-unsaturated carbonyl (PUSC) motif confer strong tyrosinase inhibitory activity,…”
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Exploration of Compounds with 2-Phenylbenzo[ d ]oxazole Scaffold as Potential Skin-Lightening Agents through Inhibition of Melanin Biosynthesis and Tyrosinase Activity by Jung, Hee Jin, Park, Hyeon Seo, Park, Hye Soo, Kim, Hye Jin, Yoon, Dahye, Park, Yujin, Chun, Pusoon, Chung, Hae Young, Moon, Hyung Ryong

“…Inspired by the potent tyrosinase inhibitory activity of phenolic compounds with a 2-phenylbenzo[ ]thiazole scaffold, we explored phenolic compounds - with…”
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