Search Results - "Ryn, Collin Van"

Irinotecan–temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial by Mody, Rajen, MD, Naranjo, Arlene, PhD, Van Ryn, Collin, MS, Yu, Alice L, Prof, London, Wendy B, PhD, Shulkin, Barry L, Prof, Parisi, Marguerite T, Prof, Servaes, Sabah-E-Noor, MD, Diccianni, Mitchell B, PhD, Sondel, Paul M, Prof, Bender, Julia G, MD, Maris, John M, Prof, Park, Julie R, Prof, Bagatell, Rochelle, Dr

“…Summary Background Outcomes for children with relapsed and refractory neuroblastoma are dismal. The combination of irinotecan and temozolomide has activity in…”
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Scalable, semi-automated fluorescence reduction neutralization assay for qualitative assessment of Ebola virus-neutralizing antibodies in human clinical samples by Postnikova, Elena N, Pettitt, James, Van Ryn, Collin J, Holbrook, Michael R, Bollinger, Laura, Yú, Shuǐqìng, Caì, Yíngyún, Liang, Janie, Sneller, Michael C, Jahrling, Peter B, Hensley, Lisa E, Kuhn, Jens H, Fallah, Mosoka P, Bennett, Richard S, Reilly, Cavan

“…Antibody titers against a viral pathogen are typically measured using an antigen binding assay, such as an enzyme-linked immunosorbent assay (ELISA), which…”
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MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children's oncology group by Niemas-Teshiba, Risa, Matsuno, Ryosuke, Wang, Larry L, Tang, Xao X, Chiu, Bill, Zeki, Jasmine, Coburn, Jeannine, Ornell, Kimberly, Naranjo, Arlene, Van Ryn, Collin, London, Wendy B, Hogarty, Michael D, Gastier-Foster, Julie M, Look, A Thomas, Park, Julie R, Maris, John M, Cohn, Susan L, Seeger, Robert C, Asgharzadeh, Shahab, Ikegaki, Naohiko, Shimada, Hiroyuki

“…Neuroblastomas with a high mitosis-karyorrhexis index (High-MKI) are often associated with amplification, MYCN protein overexpression and adverse clinical…”
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Role of the extent of prophylactic regional lymph node radiotherapy on survival in high‐risk neuroblastoma: A report from the COG A3973 study by Braunstein, Steve E., London, Wendy B., Kreissman, Susan G., Villablanca, Judith G., Davidoff, Andrew M., DeSantes, Kenneth, Castleberry, Robert P., Murray, Kevin, Diller, Lisa, Matthay, Katherine, Cohn, Susan L., Shulkin, Barry, Allmen, Daniel, Parisi, Marguerite T., Ryn, Collin, Park, Julie R., Quaglia, Michael P., Haas‐Kogan, Daphne A.

“…Purpose Neuroblastoma is the most common extracranial solid pediatric malignancy, with poor outcomes in high‐risk disease. Standard treatment approaches employ…”
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MYCN amplification and ATRX mutations are incompatible in neuroblastoma by Zeineldin, Maged, Federico, Sara, Chen, Xiang, Fan, Yiping, Xu, Beisi, Stewart, Elizabeth, Zhou, Xin, Jeon, Jongrye, Griffiths, Lyra, Nguyen, Rosa, Norrie, Jackie, Easton, John, Mulder, Heather, Yergeau, Donald, Liu, Yanling, Wu, Jianrong, Van Ryn, Collin, Naranjo, Arlene, Hogarty, Michael D., Kamiński, Marcin M., Valentine, Marc, Pruett-Miller, Shondra M., Pappo, Alberto, Zhang, Jinghui, Clay, Michael R., Bahrami, Armita, Vogel, Peter, Lee, Seungjae, Shelat, Anang, Sarthy, Jay F., Meers, Michael P., George, Rani E., Mardis, Elaine R., Wilson, Richard K., Henikoff, Steven, Downing, James R., Dyer, Michael A.

“…Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma,…”
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Clinical sequelae among individuals with pauci-symptomatic or asymptomatic Ebola virus infection and unrecognised Ebola virus disease in Liberia: a longitudinal cohort study by Kelly, J Daniel, Van Ryn, Collin, Badio, Moses, Fayiah, Tamba, Johnson, Kumblytee, Gayedyu-Dennis, Dehkontee, Weiser, Sheri D, Porco, Travis C, Martin, Jeffery N, Sneller, Michael C, Rutherford, George W, Reilly, Cavan, Fallah, Mosoka P, Moses, J Soka

“…Whether or not individuals with pauci-symptomatic or asymptomatic Ebola virus infection and unrecognised Ebola virus disease develop clinical sequelae is…”
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A subset of image‐defined risk factors predict completeness of resection in children with high‐risk neuroblastoma: An international multicenter study by Espinoza, Andres F., Bagatell, Rochelle, McHugh, Kieran, Naranjo, Arlene H., Van Ryn, Collin, Rojas, Yesenia, Lyons, Karen, Guillerman, R. Paul, Kirby, Chaim, Brock, Penelope, Volchenboum, Samuel, Simon, Thorsten, States, Lisa, Miller, Alexandra, Krug, Barbara, Sarnacki, Sabine, Irtan, Sabine, Brisse, Herve J., Valteau‐Couanet, Dominique, Schweinitz, Dietrich, Kammer, Birgit, Granata, Claudio, Pio, Luca, Park, Julie R., Nuchtern, Jed G.

“…Background Image‐defined risk factors (IDRFs) were promulgated for predicting the feasibility and safety of complete primary tumor resection in children with…”
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The impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa by Moses, Soka J, Wachekwa, Ian, Van Ryn, Collin, Grandits, Greg, Pau, Alice, Badio, Moses, Kennedy, Stephen B, Sneller, Michael C, Higgs, Elizabeth S, Lane, H Clifford, Fallah, Mosoka, Migueles, Stephen A, Reilly, Cavan

“…Detailed longitudinal studies of HIV-positive individuals in West Africa are lacking. Here the HIV prevalence, incidence, all-cause mortality, and the…”
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Long-Term Decrease in Intraocular Pressure in Survivors of Ebola Virus Disease in the Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) III Study by Mudalegundi, Shwetha, Ross, Robin D., Larbelee, Jemma, Amegashie, Fred, Dolo, Robert F., Prakalapakorn, Grace S., Ray, Vincent, Gargu, Catherine, Sosu, Yassah, Sackor, Jennie, Cooper, Precious Z., Wallace, Augustine, Nyain, Ruth, Burkholder, Bryn, Van Ryn, Collin, Davis, Bionca, Fallah, Mosoka P., Reilly, Cavan, Bishop, Rachel J., Eghrari, Allen O.

“…Survivors of Ebola virus disease (EVD) experience decreased intraocular pressure (IOP) relative to unaffected close contacts during the first year of…”
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Efficacy and Safety Outcomes of Cataract Surgery in Survivors of Ebola Virus Disease: 12-Month Results From the PREVAIL VII Study by Eghrari, Allen O, Shantha, Jessica G, Ross, Robin D, Ryn, Collin Van, Crozier, Ian, Hayek, Brent, Gradin, Dan, Roberts, Ben, Prakalapakorn, S Grace, Amegashie, Fred, Nishant, Kumar, Singh, Gurcharan, Dolo, Robert, Fankhauser, John, Burkholder, Bryn, Pettitt, James, Gross, Robin, Brady, Tyler, Dighero-Kemp, Bonnie, Reilly, Cavan, Hensley, Lisa, Higgs, Elizabeth, Yeh, Steven, Bishop, Rachel J

“…In survivors of Ebola virus disease (EVD), intraocular viral persistence raises questions about the timing and safety of cataract surgery. To the best of our…”
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Historical time to disease progression and progression‐free survival in patients with recurrent/refractory neuroblastoma treated in the modern era on Children's Oncology Group early‐phase trials by London, Wendy B., Bagatell, Rochelle, Weigel, Brenda J., Fox, Elizabeth, Guo, Dongjing, Van Ryn, Collin, Naranjo, Arlene, Park, Julie R.

“…BACKGROUND Early‐phase trials in patients with recurrent neuroblastoma historically used an objective “response” of measureable disease (Response Evaluation…”
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Association of MYCN copy number with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology Group by Campbell, Kevin, Gastier‐Foster, Julie M., Mann, Meegan, Naranjo, Arlene H., Ryn, Collin, Bagatell, Rochelle, Matthay, Katherine K., London, Wendy B., Irwin, Meredith S., Shimada, Hiroyuki, Granger, M. Meaghan, Hogarty, Michael D., Park, Julie R., DuBois, Steven G.

“…BACKGROUND High‐level MYCN amplification (MNA) is associated with poor outcome and unfavorable clinical and biological features in patients with neuroblastoma…”
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Impact of Extent of Resection on Local Control and Survival in Patients From the COG A3973 Study With High-Risk Neuroblastoma by von Allmen, Daniel, Davidoff, Andrew M, London, Wendy B, Van Ryn, Collin, Haas-Kogan, Daphne A, Kreissman, Susan G, Khanna, Geetika, Rosen, Nancy, Park, Julie R, La Quaglia, Michael P

“…Purpose This analysis of patients in the Children's Oncology Group A3973 study evaluated the impact of extent of primary tumor resection on local progression…”
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Antitumor Activity and Tolerability of hu14.18-IL2 with GMCSF and Isotretinoin in Recurrent or Refractory Neuroblastoma: A Children's Oncology Group Phase II Study by Shusterman, Suzanne, Naranjo, Arlene, Van Ryn, Collin, Hank, Jaquelyn A, Parisi, Marguerite T, Shulkin, Barry L, Servaes, Sabah, London, Wendy B, Shimada, Hiroyuki, Gan, Jacek, Gillies, Steven D, Maris, John M, Park, Julie R, Sondel, Paul M

“…Combining anti-GD2 (disialoganglioside) mAb with GM-CSF, IL2, and isotretinoin is now FDA-approved for high-risk neuroblastoma minimal residual disease (MRD)…”
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Prevalence and Clinical Correlations of Somatostatin Receptor-2 (SSTR2) Expression in Neuroblastoma by Alexander, Natasha, Marrano, Paula, Thorner, Paul, Naranjo, Arlene, Van Ryn, Collin, Martinez, Daniel, Batra, Vandana, Zhang, Libo, Irwin, Meredith S, Baruchel, Sylvain

“…Alternative radiolabeled, targeted agents are being investigated for children with relapsed neuroblastoma (NB) who do not respond to I-metaiodobenzylguanidine…”
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Prevalence and incidence of transfusion‐transmissible infections among blood donors in Malawi: A population‐level study by Singogo, Emmanuel, Chagomerana, Maganizo, Van Ryn, Collin, M'bwana, Robert, Likaka, Andrew, M'baya, Bridon, Puerto‐Meredith, Sydney, Chipeta, Effie, Mwapasa, Victor, Muula, Adamson, Reilly, Cavan, Hosseinipour, Mina C.

“…Background Voluntary non‐remunerated blood donors (VNRBDs) are essential to sustain national blood supplies. Expanding testing capacity for the major…”
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Historical time-to-progression (TTP) and progression-free survival (PFS) in relapsed/refractory neuroblastoma modern-era (2002-14) patients from Children’s Oncology Group (COG) early-phase trials by London, Wendy B, Bagatell, Rochelle, Weigel, Brenda J, Fox, Elizabeth, Guo, Dongjing, Van Ryn, Collin, Naranjo, Arlene, Park, Julie R

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Assessment of Primary Site Response in Children With High-Risk Neuroblastoma: An International Multicenter Study by Bagatell, Rochelle, McHugh, Kieran, Naranjo, Arlene, Van Ryn, Collin, Kirby, Chaim, Brock, Penelope, Lyons, Karen A, States, Lisa J, Rojas, Yesenia, Miller, Alexandra, Volchenboum, Sam L, Simon, Thorsten, Krug, Barbara, Sarnacki, Sabine, Valteau-Couanet, Dominique, von Schweinitz, Dietrich, Kammer, Birgit, Granata, Claudio, Pio, Luca, Park, Julie R, Nuchtern, Jed

“…The International Neuroblastoma Response Criteria (INRC) require serial measurements of primary tumors in three dimensions, whereas the Response Evaluation…”
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Anti-tumor activity and tolerability of hu14.18-IL2 with GMCSF and isotretinoin in recurrent or refractory neuroblastoma: a Children’s Oncology Group phase II study by Shusterman, Suzanne, Naranjo, Arlene, Van Ryn, Collin, Hank, Jaquelyn A., Parisi, Marguerite T., Shulkin, Barry L., Servaes, Sabah, London, Wendy B., Shimada, Hiroyuki, Gan, Jacek, Gillies, Steven D., Maris, John M., Park, Julie R., Sondel, Paul M.

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MIBG avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology Group by DuBois, Steven G., Mody, Rajen, Naranjo, Arlene, Ryn, Collin, Russ, Douglas, Oldridge, Derek, Kreissman, Susan, Baker, David L., Parisi, Marguerite, Shulkin, Barry L., Bai, Harrison, Diskin, Sharon J., Batra, Vandana, Maris, John M., Park, Julie R., Matthay, Katherine K., Yanik, Gregory

“…Background Prior studies suggest that neuroblastomas that do not accumulate metaiodobenzylguanidine (MIBG) on diagnostic imaging (MIBG non‐avid) may have more…”
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