Search Results - "Ryle, P"

Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody by Reilly, M, Miller, R M, Thomson, M H, Patris, V, Ryle, P, McLoughlin, L, Mutch, P, Gilboy, P, Miller, C, Broekema, M, Keogh, B, McCormack, W, van de Wetering de Rooij, J

“…Upregulation of Toll‐like receptor 2 (TLR2) plays a critical role in inflammation associated with ischemia/reperfusion–induced tissue damage. OPN‐305 is the…”
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Calibration of a digital in-line holographic microscopy system: depth of focus and bioprocess analysis by Ryle, James P, McDonnell, Susan, Glennon, Brian, Sheridan, John T

“…Digital in-line holographic microscopy (DIHM) allows access to both intensity and phase information with conventional microscopic lateral resolutions. Such…”
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Blue light from individual light masks directed at a single eye advances the breeding season in mares by Murphy, B. A., Walsh, C. M., Woodward, E. M., Prendergast, R. L., Ryle, J. P., Fallon, L. H., Troedsson, M. H. T.

“…Summary Reasons for performing study Artificial lighting is commonly used to advance the breeding season in horses. Light masks have been developed that direct…”
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Simultaneous drift, microsaccades, and ocular microtremor measurement from a single noncontact far-field optical sensor by Ryle, James P., Vohnsen, Brian, Sheridan, John T.

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Lensless multispectral digital in-line holographic microscope by Ryle, James P, Sheridan, John T, McDonnell, Susan

“…An compact multispectral digital in-line holographic microscope (DIHM) is developed that emulates Gabor's original holographic principle. Using sources of…”
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Simultaneous drift, microsaccades, and ocular microtremor measurement from a single noncontact far-field optical sensor by Ryle, James P, Vohnsen, Brian, Sheridan, John T

“…We report on the combined far-field measurement of the three involuntary eye movements, drift, microsaccades, and ocular microtremor (OMT), using a noncontact…”
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Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine by Bridgeman, M. M., Marsden, M., MacNee, W., Flenley, D. C., Ryle, A. P.

“…N-acetylcysteine (600 mg/day) was given to patients by mouth for five days before bronchoscopy and bronchoalveolar lavage to determine whether N-acetylcysteine…”
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Secretion of mucus proteinase inhibitor and elafin by Clara cell and type II pneumocyte cell lines by Sallenave, J M, Silva, A, Marsden, M E, Ryle, A P

“…The regulation of proteinases secreted by neutrophils is very important for the prevention of tissue injury. We recently described the isolation of elafin from…”
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Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity by Sallenave, J M, Marsden, M D, Ryle, A P

“…Evidence is presented that the elastase-specific inhibitor of Mr 2500 (Sallenave, J.-M. & Ryle, A.P. (1991) Biol. Chem. Hoppe-Seyler 372, 13-21) is a…”
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Compact portable ocular microtremor sensor: design, development and calibration by Ryle, James P, Al-Kalbani, Mohammed, Collins, Niamh, Gopinathan, Unnikrishnan, Boyle, Gerard, Coakley, Davis, Sheridan, John T

“…Ocular microtremor (OMT) is a physiological high-frequency (up to ) low-amplitude ( peak-to-peak) involuntary motion of the human eye. Recent studies suggest a…”
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Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor by Sallenave, J M, Ryle, A P

“…Elastase-specific inhibitor (ESI) was purified from sputum of patients with chronic bronchitis and compared with mucus proteinase inhibitor (MPI, BrI)…”
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The effect of methylene blue on the hepatocellular redox state and liver lipid content during chronic ethanol feeding in the rat by Ryle, P R, Chakraborty, J, Thomson, A D

“…Feeding of ethanol in a liquid diet to male Wistar rats caused decreases in the hepatic cytosolic and mitochondrial [NAD+]/[NADH] ratios. This redox-state…”
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Justification for routine screening of pharmaceutical products in immune function tests: a review of the recommendations of Putman et al. (2003) by Ryle, Peter R.

“…In a recent publication by Putman et al. (2003), salmeterol, morphine/methadone and buprenorphine were quoted as examples of pharmaceutical drugs whose…”
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Proteolysis of lung elastin by human neutrophil elastase by Hannah, S, Ryle, A P

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Alcoholic malnutrition and the small intestine by World, M J, Ryle, P R, Thomson, A D

“…Malnutrition is common in chronic alcoholics, although its severity may depend on the social characteristics of the patient group under study and their…”
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Alloxan-induced diabetes in the rat - protective action of (-) epicatechin? by Ryle, P R, Barker, J, Gaines, P A, Thomson, A D, Chakraborty, J

“…Administration of alloxan (150 mg/kg body weight, i.p.) to male Wistar rats induced a reproducible and persistent diabetes mellitus as evidenced by elevated…”
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The effect of di-isopropyl 1,3 dithiol-2-ylidenemalonate (malotilate) on the hepatic changes induced by ethanol administration in the rat by Ryle, P R, Chakraborty, J, Thomson, A D

“…The sulphur-containing drug, di-isopropyl-1,3-dithiol-2-ylidenemalonate (Malotilate) protects against the increase in hepatic triglyceride concentration after…”
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The roles of the hepatocellular redox state and the hepatic acetaldehyde concentration in determining the ethanol elimination rate in fasted rats by Ryle, P R, Chakraborty, J, Thomson, A D

“…Ethanol administration (2 g/kg i.p.) to fasted male Wistar rats caused, on average, a 64% decrease in the cytosolic free NAD+:NADH ratio and a 41% decrease in…”
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The role of the hepatocellular redox state in the hepatic triglyceride accumulation following acute ethanol administration by Ryle, P R, Chakraborty, J, Thomson, A D

“…The role of the increased hepatocellular redox-state [( NADH]/[NAD+] ratio) as a mechanism underlying hepatic triglyceride deposition after acute ethanol…”
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Free radicals, lipid peroxidation, and ethanol hepatotoxicity by Ryle, P R

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