Search Results - "Rylander Ottosson, Daniella"

Direct reprogramming into interneurons: potential for brain repair by Pereira, Maria, Birtele, Marcella, Rylander Ottosson, Daniella

“…The brain tissue has only a limited capacity for generating new neurons. Therefore, to treat neurological diseases, there is a need of other cell sources for…”
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In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry by Torper, Olof, Ottosson, Daniella Rylander, Pereira, Maria, Lau, Shong, Cardoso, Tiago, Grealish, Shane, Parmar, Malin

“…The possibility of directly converting non-neuronal cells into neurons in situ in the brain would open therapeutic avenues aimed at repairing the brain after…”
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Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum by Aldrin-Kirk, Patrick, Heuer, Andreas, Rylander Ottosson, Daniella, Davidsson, Marcus, Mattsson, Bengt, Björklund, Tomas

“…The intricate balance between dopaminergic and cholinergic neurotransmission in the striatum has been thoroughly difficult to characterize. It was initially…”
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Direct neural conversion from human fibroblasts using self-regulating and nonintegrating viral vectors by Lau, Shong, Rylander Ottosson, Daniella, Jakobsson, Johan, Parmar, Malin

“…Recent findings show that human fibroblasts can be directly programmed into functional neurons without passing via a proliferative stem cell intermediate…”
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REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and ‐independent pathways by Drouin‐Ouellet, Janelle, Lau, Shong, Brattås, Per Ludvik, Rylander Ottosson, Daniella, Pircs, Karolina, Grassi, Daniela A, Collins, Lucy M, Vuono, Romina, Andersson Sjöland, Annika, Westergren‐Thorsson, Gunilla, Graff, Caroline, Minthon, Lennart, Toresson, Håkan, Barker, Roger A, Jakobsson, Johan, Parmar, Malin

“…Direct conversion of human fibroblasts into mature and functional neurons, termed induced neurons (iNs), was achieved for the first time 6 years ago. This…”
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Embedded 3D Printing in Self‐Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs by Kajtez, Janko, Wesseler, Milan Finn, Birtele, Marcella, Khorasgani, Farinaz Riyahi, Rylander Ottosson, Daniella, Heiskanen, Arto, Kamperman, Tom, Leijten, Jeroen, Martínez‐Serrano, Alberto, Larsen, Niels B., Angelini, Thomas E., Parmar, Malin, Lind, Johan U., Emnéus, Jenny

“…Human in vitro models of neural tissue with tunable microenvironment and defined spatial arrangement are needed to facilitate studies of brain development and…”
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Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons by Giacomoni, Jessica, Bruzelius, Andreas, Stamouli, Christina-Anastasia, Rylander Ottosson, Daniella

“…Glial progenitor cells are widely distributed in brain parenchyma and represent a suitable target for future therapeutic interventions that generate new…”
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Reprogramming Human Adult Fibroblasts into GABAergic Interneurons by Bruzelius, Andreas, Kidnapillai, Srisaiyini, Drouin-Ouellet, Janelle, Stoker, Tom, Barker, Roger A, Rylander Ottosson, Daniella

“…Direct reprogramming is an appealing strategy to generate neurons from a somatic cell by forced expression of transcription factors. The generated neurons can…”
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Protocol for optical clearing and imaging of fluorescently labeled ex vivo rat brain slices by Giacomoni, Jessica, Habekost, Mette, Cepeda-Prado, Efrain, Mattsson, Bengt, Ottosson, Daniella Rylander, Parmar, Malin, Kajtez, Janko

“…Tissue clearing is commonly used for whole-brain imaging but seldom used for brain slices. Here, we present a simple protocol to slice, immunostain, and clear…”
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Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids by Fiorenzano, Alessandro, Sozzi, Edoardo, Birtele, Marcella, Kajtez, Janko, Giacomoni, Jessica, Nilsson, Fredrik, Bruzelius, Andreas, Sharma, Yogita, Zhang, Yu, Mattsson, Bengt, Emnéus, Jenny, Ottosson, Daniella Rylander, Storm, Petter, Parmar, Malin

“…Three-dimensional brain organoids have emerged as a valuable model system for studies of human brain development and pathology. Here we establish a midbrain…”
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Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson’s Disease by Kirkeby, Agnete, Nolbrant, Sara, Tiklova, Katarina, Heuer, Andreas, Kee, Nigel, Cardoso, Tiago, Ottosson, Daniella Rylander, Lelos, Mariah J., Rifes, Pedro, Dunnett, Stephen B., Grealish, Shane, Perlmann, Thomas, Parmar, Malin

“…Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials soon. Most of the approaches currently under development involve…”
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Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain by Birtele, Marcella, Storm, Petter, Sharma, Yogita, Kajtez, Janko, Wahlestedt, Jenny Nelander, Sozzi, Edoardo, Nilsson, Fredrik, Stott, Simon, He, Xiaoling L, Mattsson, Bengt, Ottosson, Daniella Rylander, Barker, Roger A, Fiorenzano, Alessandro, Parmar, Malin

“…Significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells for…”
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Editorial: Regeneration and Brain Repair by Rylander Ottosson, Daniella, Grade, Sofia, Heuer, Andreas

“…In the future, cell replacement strategies might also involve in situ cell type conversion e.g., via forced expression of neurogenic transcription factors in…”
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Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons by Pereira, Maria, Birtele, Marcella, Shrigley, Shelby, Benitez, Julio Aguila, Hedlund, Eva, Parmar, Malin, Ottosson, Daniella Rylander

“…Converting resident glia into functional and subtype-specific neurons in vivo by delivering reprogramming genes directly to the brain provides a step forward…”
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Author Correction: Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids by Fiorenzano, Alessandro, Sozzi, Edoardo, Birtele, Marcella, Kajtez, Janko, Giacomoni, Jessica, Nilsson, Fredrik, Bruzelius, Andreas, Sharma, Yogita, Zhang, Yu, Mattsson, Bengt, Emnéus, Jenny, Ottosson, Daniella Rylander, Storm, Petter, Parmar, Malin

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Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming by Ruetz, Tyson, Pfisterer, Ulrich, Di Stefano, Bruno, Ashmore, James, Beniazza, Meryam, Tian, Tian V., Kaemena, Daniel F., Tosti, Luca, Tan, Wenfang, Manning, Jonathan R., Chantzoura, Eleni, Ottosson, Daniella Rylander, Collombet, Samuel, Johnsson, Anna, Cohen, Erez, Yusa, Kosuke, Linnarsson, Sten, Graf, Thomas, Parmar, Malin, Kaji, Keisuke

“…Reprogramming of cellular identity using exogenous expression of transcription factors (TFs) is a powerful and exciting tool for tissue engineering, disease…”
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Striatal Plasticity in L-DOPA- and Graft-Induced Dyskinesia; The Common Link? by Rylander Ottosson, Daniella, Lane, Emma

“…One of the major symptoms of the neurodegenerative condition Parkinson's disease (PD) is a slowness or loss of voluntary movement, yet frustratingly…”
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Silk scaffolding drives self-assembly of functional and mature human brain organoids by Sozzi, Edoardo, Kajtez, Janko, Bruzelius, Andreas, Wesseler, Milan Finn, Nilsson, Fredrik, Birtele, Marcella, Larsen, Niels B., Ottosson, Daniella Rylander, Storm, Petter, Parmar, Malin, Fiorenzano, Alessandro

“…Human pluripotent stem cells (hPSCs) are intrinsically able to self-organize into cerebral organoids that mimic features of developing human brain tissue…”
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Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia by Canals, Isaac, Comella-Bolla, Andrea, Cepeda-Prado, Efrain, Avaliani, Natalia, Crowe, James A, Oburoglu, Leal, Bruzelius, Andreas, King, Naomi, Pajares, María A, Pérez-Sala, Dolores, Heuer, Andreas, Rylander Ottosson, Daniella, Soriano, Jordi, Ahlenius, Henrik

“…Abstract Frontotemporal dementia (FTD) is the second most prevalent type of early-onset dementia and up to 40% of cases are familial forms. One of the genes…”
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Functional Assessment of Direct Reprogrammed Neurons In Vitro and In Vivo by Kidnapillai, Srisaiyini, Ottosson, Daniella Rylander

“…Direct reprogramming is an emerging research field where you can generate neurons from a somatic cell, such as a skin or glial cell by overexpressing…”
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