Search Results - "Ryhanen, Samppa"

Circulating Concentrations of Soluble Receptor for AGE Are Associated With Age and AGER Gene Polymorphisms in Children With Newly Diagnosed Type 1 Diabetes by SALONEN, Kirsi M, RYHÄNEN, Samppa J, FORBES, Josephine M, HÄRKÖNEN, Taina, ILONEN, Jorma, LAINE, Antti-Pekka, GROOP, Per-Henrik, KNIP, Mikael

“…We analyzed the relationship among soluble receptor for advanced glycation end products (sRAGEs), the clinical phenotype, HLA genotype, and risk-associated…”
Get full text

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability by Yassour, Moran, Vatanen, Tommi, Siljander, Heli, Hämäläinen, Anu-Maaria, Härkönen, Taina, Ryhänen, Samppa J, Franzosa, Eric A, Vlamakis, Hera, Huttenhower, Curtis, Gevers, Dirk, Lander, Eric S, Knip, Mikael, Xavier, Ramnik J

“…The gut microbial community is dynamic during the first 3 years of life, before stabilizing to an adult-like state. However, little is known about the impact…”
Get more information

Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years by Pöllänen, Petra M, Ryhänen, Samppa J, Toppari, Jorma, Ilonen, Jorma, Vähäsalo, Paula, Veijola, Riitta, Siljander, Heli, Knip, Mikael

“…Abstract Context We set out to characterize the dynamics of islet autoantibodies over the first 15 years of life in children carrying genetic susceptibility to…”
Get full text

Extended Family History of Type 1 Diabetes and Phenotype and Genotype of Newly Diagnosed Children by PARKKOLA, Anna, HARKONEN, Taina, RYHANEN, Samppa J, ILONEN, Jorma, KNIP, Mikael

“…To determine the frequency of newly diagnosed diabetic children with first- and second-degree relatives affected by type 1 diabetes and to characterize the…”
Get full text

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage by Pfisterer, Simon G., Gateva, Gergana, Horvath, Peter, Pirhonen, Juho, Salo, Veijo T., Karhinen, Leena, Varjosalo, Markku, Ryhänen, Samppa J., Lappalainen, Pekka, Ikonen, Elina

“…Lipid droplets (LDs) are cellular organelles specialized in triacylglycerol (TG) storage undergoing homotypic clustering and fusion. In non-adipocytic cells…”
Get full text

HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes by Parkkola, Anna, Laine, Antti-Pekka, Karhunen, Markku, Härkönen, Taina, Ryhänen, Samppa J, Ilonen, Jorma, Knip, Mikael

“…Genetic predisposition could be assumed to be causing clustering of autoimmunity in individuals and families. We tested whether HLA and non-HLA loci associate…”
Get full text

Transglutaminase antibodies and celiac disease in children with type 1 diabetes and in their family members by Parkkola, Anna, Härkönen, Taina, Ryhänen, Samppa J, Uibo, Raivo, Ilonen, Jorma, Knip, Mikael

“…Objectives We set out to determine the prevalence of tissue transglutaminase antibodies (anti‐tTG) and celiac disease (CD) in children with newly diagnosed…”
Get full text

Wiskott-Aldrich syndrome: a study of 577 patients defines the genotype as a biomarker for disease severity and survival by Vallée, Tanja C., Glasmacher, Jannik S., Buchner, Hannes, Arkwright, Peter D., Behrends, Uta, Bondarenko, Anastasia, Browning, Michael J., Buchbinder, David, Cattoni, Alessandro, Chernyshova, Liudmyla, Ciznar, Peter, Cole, Theresa, Czogała, Wojciech, Dueckers, Gregor, Edgar, John David M., Erbey, Fatih, Fasth, Anders, Ferrua, Francesca, Formankova, Renata, Gambineri, Eleonora, Gennery, Andrew R., Goldman, Frederick D., Gonzalez-Granado, Luis I., Heilmann, Carsten, Heiskanen-Kosma, Tarja, Juntti, Hanna, Kainulainen, Leena, Kanegane, Hirokazu, Karaca, Neslihan E., Kilic, Sara S., Klein, Christoph, Kołtan, Sylwia, Kondratenko, Irina, Meyts, Isabelle, Nasrullayeva, Gulnara M., Notarangelo, Lucia D., Pasic, Srdjan, Pellier, Isabelle, Pignata, Claudio, Misbah, Siraj, Schulz, Ansgar, Segundo, Gesmar R., Shcherbina, Anna, Slatter, Mary, Sokolic, Robert, Soler-Palacin, Pere, Stepensky, Polina, van Montfrans, Joris M., Ryhänen, Samppa, Wolska-Kuśnierz, Beata, Ziegler, John B., Zhao, Xiaodong, Aiuti, Alessandro, Ochs, Hans D., Albert, Michael H.

“…•The type of genetic variant is a predictive biomarker for disease severity and survival in WAS.•Less severe variants entail a later onset of disease-related…”
Get full text

Alternative donor transplantation for severe aplastic anemia: a comparative study of the SAAWP EBMT by Montoro, Juan, Eikema, Dirk-Jan, Tuffnell, Joe, Potter, Victoria, Kalwak, Krzysztof, Halkes, Constantijn J. M., Kulagin, Alexander, Collin, Matthew, Wynn, Robert F., Robinson, Stephen, Nicholson, Emma, Sengeloev, Henrik, Clay, Jennifer, Halahleh, Khalid, Skorobogatova, Elena, Sanz, Jaime, Passweg, Jakob, Mielke, Stephan, Ryhänen, Samppa, Carpenter, Ben, Gedde-Dahl, Tobias, Tholouli, Eleni, Fanin, Renato, Lewalle, Philippe, Kulasekararaj, Austin, Risitano, Antonio, Peffault de Latour, Régis

“…•SCT from MUD offers superior survival outcomes for severe aplastic anemia compared with both MMUD and Haplo SCT.•The decision between an MMUD and Haplo donor…”
Get full text

Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1 by Roach, Tiffany G, Lång, Heljä K M, Xiong, Wen, Ryhänen, Samppa J, Capelluto, Daniel G S

“…Lysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on the function of Endosomal Sorting Complex Required for Transport…”
Get full text

Characterization of Mixed Monolayers of Phosphatidylcholine and a Dicationic Gemini Surfactant SS-1 with a Langmuir Balance: Effects Of DNA by Matti, V., Säily, J., Ryhänen, Samppa J., Holopainen, Juha M., Borocci, Stefano, Mancini, Giovanna, Kinnunen, Paavo K.J.

“…Monolayers of a cationic gemini surfactant, 2,3-dimethoxy-1,4-bis( N-hexadecyl- N; N-dimethyl-ammonium)butane dibromide (abbreviated as SS-1) and its mixtures…”
Get full text

Decrease in circulating concentrations of soluble receptors for advanced glycation end products at the time of seroconversion to autoantibody positivity in children with prediabetes by Salonen, Kirsi M, Ryhänen, Samppa J, Forbes, Josephine M, Borg, Danielle J, Härkönen, Taina, Ilonen, Jorma, Simell, Olli, Veijola, Riitta, Groop, Per-Henrik, Knip, Mikael

“…Dietary advanced glycation end products (AGEs) and their interactions with the receptor for AGEs (RAGE) may play a role in the pathogenesis of type 1 diabetes…”
Get full text

Extended family history of autoimmune diseases and phenotype and genotype of children with newly diagnosed type 1 diabetes by Parkkola, Anna, Härkönen, Taina, Ryhänen, Samppa J, Ilonen, Jorma, Knip, Mikael

“…ObjectiveBased on the concept of clustering autoimmunity, children with a positive family history of autoimmunity could be expected to have a different…”
Get full text

Impact of Intranasal Insulin on Insulin Antibody Affinity and Isotypes in Young Children With HLA-Conferred Susceptibility to Type 1 Diabetes by Ryhänen, Samppa J, Härkönen, Taina, Siljander, Heli, Näntö-Salonen, Kirsti, Simell, Tuula, Hyöty, Heikki, Ilonen, Jorma, Veijola, Riitta, Simell, Olli, Knip, Mikael

“…OBJECTIVE: Despite promising results from studies on mouse models, intranasal insulin failed to prevent or delay the development of type 1 diabetes in…”
Get full text

Early childhood infections and the use of antibiotics and antipyretic‐analgesics in Finland, Estonia and Russian Karelia by Mustonen, Neea, Siljander, Heli, Peet, Aleksandr, Tillmann, Vallo, Härkönen, Taina, Ilonen, Jorma, Hyöty, Heikki, Knip, Mikael, Koski, Katriina, Koski, Matti, Ryhänen, Samppa, Hämäläinen, Anu‐Maaria, Ormisson, Anne, Ulich, Valentina, Kuzmicheva, Elena, Mokurov, Sergei, Markova, Svetlana, Pylova, Svetlana, Isakova, Marina, Shakurova, Elena, Petrov, Vladimir, Dorshakova, Natalya V., Karapetyan, Tatyana, Varlamova, Tatyana, Kiviniemi, Minna, Alnek, Kristi, Janson, Helis, Uibo, Raivo, von Mutius, Erika, Weber, Juliane, Ahlfors, Helena, Kallionpää, Henna, Laajala, Essi, Lähdesmäki, Harri, Lahesmaa, Riitta, Moulder, Robert, Nieminen, Janne, Ruohtula, Terhi, Vaarala, Outi, Honkanen, Hanna, Kondrashova, Anita, Oikarinen, Sami, Harmsen, Hermie J.M., De Goffau, Marcus C., Welling, Gjalt, Alahuhta, Kirsi, Virtanen, Suvi M.

“…Aim Infections in early childhood are common reasons to seek medical attention. This study compares the prevalence of infections, and the use of antibiotics…”
Get full text

Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life by Ruohtula, Terhi, Kondrashova, Anita, Lehtonen, Jussi, Oikarinen, Sami, Hämäläinen, Anu-Maaria, Niemelä, Onni, Peet, Aleksandr, Tillmann, Vallo, Nieminen, Janne K, Ilonen, Jorma, Knip, Mikael, Vaarala, Outi, Hyöty, Heikki

“…Early childhood infections have been implicated in the development of immune-mediated diseases, such as allergies, asthma, and type 1 diabetes. We set out to…”
Get full text

Standard of hygiene and immune adaptation in newborn infants by Kallionpää, Henna, Laajala, Essi, Öling, Viveka, Härkönen, Taina, Tillmann, Vallo, Dorshakova, Natalya V, Ilonen, Jorma, Lähdesmäki, Harri, Knip, Mikael, Lahesmaa, Riitta

“…Abstract The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore…”
Get full text

Emapalumab for Treatment of Impending Graft Failure by Sabulski, Anthony, Jodele, Sonata, Cook, Eleanor, Myers, Kasiani, Lane, Adam C., Ryhanen, Samppa, Cefalo, Maria Pia, Quagliarella, Francesco, Davies, Stella M, Teusink-Cross, Ashley, Aguayo-Hiraldo, Paibel, Alexander, Jessie L., Szabolcs, Paul, Kohorst, Mira, Corsetti, Tiziana, Locatelli, Franco, Merli, Pietro

“…Introduction: Immune-mediated graft failure (also termed graft rejection) is a feared complication of hematopoietic stem cell transplant (HSCT) and there is no…”
Get full text

Influence of the Spacer of Cationic Gemini Amphiphiles on the Hydration of Lipoplexes by Luciani, Paola, Bombelli, Cecilia, Colone, Marisa, Giansanti, Luisa, Ryhänen, Samppa J, Säily, V. Matti J, Mancini, Giovanna, Kinnunen, Paavo K. J

“…The impact of the length of gemini surfactant spacer on complexation and condensation of calf thymus DNA by cationic mixed phospholipid/gemini liposomes was…”
Get full text

Alternative Donor Transplantation for Severe Aplastic Anemia: A Comparative Study of the Saawp EBMT by Montoro, Juan, Eikema, Dirk-Jan, Tuffnell, Joe, Potter, Victoria, Kalwak, Krzysztof, Halkes, Stijn, Kulagin, Aleksandr, Collin, Matthew P., Wynn, Robert, Robinson, Stephen, Nicholson, Emma, Sengeloev, Henrik, Clay, Jennifer, Halahleh, Khaled, Skorobogatova, Elena, Passweg, Jakob, Mielke, Stephan, Ryhanen, Samppa, Carpenter, Ben, Gedde-Dahl, Tobias, Tholouli, Eleni, Fanin, Renato, Lewalle, Philippe, Kulasekararaj, Austin, Risitano, Antonio M, Peffault De Latour, Regis

“…Alternative donor transplantation for severe aplastic anemia: a comparative study of the SAAWP EBMT INTRODUCTION Allogeneic stem cell transplantation…”
Get full text