Search Results - "Rydzik, Anna M"

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain by Chan, Mun Chiang, Atasoylu, Onur, Hodson, Emma, Tumber, Anthony, Leung, Ivanhoe K H, Chowdhury, Rasheduzzaman, Gómez-Pérez, Verónica, Demetriades, Marina, Rydzik, Anna M, Holt-Martyn, James, Tian, Ya-Min, Bishop, Tammie, Claridge, Timothy D W, Kawamura, Akane, Pugh, Christopher W, Ratcliffe, Peter J, Schofield, Christopher J

“…As part of the cellular adaptation to limiting oxygen availability in animals, the expression of a large set of genes is activated by the upregulation of the…”
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Gymnotic uptake of AntimiRs alter microRNA-34a levels in 2D and 3D epithelial cell culture by Weidner, Julie, Kolosionek, Ewa, Holmila, Reetta, Ax, Elisabeth, Garreau, Marion, Gnerlich, Felix, Olsson, Henric, Czechtizky, Werngard, Vollmer, Stefan, Rydzik, Anna M.

“…MicroRNAs are attractive therapeutic targets in many diseases, including chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Among…”
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Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis by Rydzik, Anna M., Kulis, Marta, Lukaszewicz, Maciej, Kowalska, Joanna, Zuberek, Joanna, Darzynkiewicz, Zbigniew M., Darzynkiewicz, Edward, Jemielity, Jacek

“…We describe synthesis and properties of eight dinucleotide mRNA 5′ cap analogs containing imidodiphosphate moiety within 5′,5′-tri- or tetraphosphate bridge…”
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Synthesis of 2′-modified N6-methyladenosine phosphoramidites and their incorporation into siRNA by Rydzik, Anna M., Riether, Doris, Gottschling, Dirk

“…[Display omitted] A synthesis of 2′-fluoro and 2′-methoxy N6-methyladenosine phosphoramidites and their successful incorporation into oligonucleotides is…”
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Access to 1′-Amino Carbocyclic Phosphoramidite to Enable Postsynthetic Functionalization of Oligonucleotides by Rydzik, Anna M, Balk, Regina, Koegler, Martin, Steinle, Tobias, Riether, Doris, Gottschling, Dirk

“…We report a synthesis of a carbocyclic, abasic RNA phosphoramidite decorated with an amino functionality. The building block was efficiently incorporated into…”
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Interaction of Avibactam with Class B Metallo-β-Lactamases by Abboud, Martine I, Damblon, Christian, Brem, Jürgen, Smargiasso, Nicolas, Mercuri, Paola, Gilbert, Bernard, Rydzik, Anna M, Claridge, Timothy D W, Schofield, Christopher J, Frère, Jean-Marie

“…β-Lactamases are the most important mechanisms of resistance to the β-lactam antibacterials. There are two mechanistic classes of β-lactamases: the serine…”
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Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition by Brem, Jürgen, van Berkel, Sander S., Aik, WeiShen, Rydzik, Anna M., Avison, Matthew B., Pettinati, Ilaria, Umland, Klaus-Daniel, Kawamura, Akane, Spencer, James, Claridge, Timothy D. W., McDonough, Michael A., Schofield, Christopher J.

“…The use of β-lactam antibiotics is compromised by resistance, which is provided by β-lactamases belonging to both metallo (MBL)- and serine (SBL)-β-lactamase…”
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Assay Platform for Clinically Relevant Metallo-β-lactamases by van Berkel, Sander S, Brem, Jürgen, Rydzik, Anna M, Salimraj, Ramya, Cain, Ricky, Verma, Anil, Owens, Raymond J, Fishwick, Colin W. G, Spencer, James, Schofield, Christopher J

“…Metallo-β-lactamases (MBLs) are a growing threat to the use of almost all clinically used β-lactam antibiotics. The identification of broad-spectrum MBL…”
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Epigenetic Modification 6‐Methyladenosine Can Impact the Potency and Specificity of siRNA by Rydzik, Anna M., Gottschling, Dirk, Simon, Eric, Skronska‐Wasek, Wioletta, Rippmann, Jörg F., Riether, Doris

“…The introduction of N6‐methyladenosine (m6 A) into siRNA targeting Factor VII impacts its potency in cells and has a significant influence on the selectivity…”
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mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation by Rydzik, Anna M, Warminski, Marcin, Sikorski, Pawel J, Baranowski, Marek R, Walczak, Sylwia, Kowalska, Joanna, Zuberek, Joanna, Lukaszewicz, Maciej, Nowak, Elzbieta, W Claridge, Timothy D, Darzynkiewicz, Edward, Nowotny, Marcin, Jemielity, Jacek

“…Analogues of the mRNA 5'-cap are useful tools for studying mRNA translation and degradation, with emerging potential applications in novel therapeutic…”
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Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases by Tarhonskaya, Hanna, Rydzik, Anna M., Leung, Ivanhoe K. H., Loik, Nikita D., Chan, Mun Chiang, Kawamura, Akane, McCullagh, James S. O., Claridge, Timothy D. W., Flashman, Emily, Schofield, Christopher J.

“…Accumulation of ( R )-2-hydroxyglutarate in cells results from mutations to isocitrate dehydrogenase that correlate with cancer. A recent study reports that (…”
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19 F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode by Leśniak, Robert K, Rydzik, Anna M, Kamps, Jos J A G, Kahn, Amjad, Claridge, Timothy D W, Schofield, Christopher J

“…The final step in the biosynthesis of l-carnitine in humans is catalysed by the 2-oxoglutarate and ferrous iron dependent oxygenase, γ-butyrobetaine…”
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Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles by Makena, Anne, Düzgün, Azer Ö, Brem, Jürgen, McDonough, Michael A, Rydzik, Anna M, Abboud, Martine I, Saral, Ayşegül, Çiçek, Ayşegül Ç, Sandalli, Cemal, Schofield, Christopher J

“…Metallo-β-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution…”
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Synthesis of Fluorophosphate Nucleotide Analogues and Their Characterization as Tools for 19F NMR Studies by Baranowski, Marek R, Nowicka, Anna, Rydzik, Anna M, Warminski, Marcin, Kasprzyk, Renata, Wojtczak, Blazej A, Wojcik, Jacek, Claridge, Timothy D. W, Kowalska, Joanna, Jemielity, Jacek

“…To broaden the scope of existing methods based on 19F nucleotide labeling, we developed a new method for the synthesis of fluorophosphate (oligo)­nucleotide…”
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Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases by Zhang, Dong, Markoulides, Marios S., Stepanovs, Dmitrijs, Rydzik, Anna M., El-Hussein, Ahmed, Bon, Corentin, Kamps, Jos J.A.G., Umland, Klaus-Daniel, Collins, Patrick M., Cahill, Samuel T., Wang, David Y., von Delft, Frank, Brem, Jürgen, McDonough, Michael A., Schofield, Christopher J.

“…[Display omitted] Metallo-β-lactamases (MBLs) enable bacterial resistance to almost all classes of β-lactam antibiotics. We report studies on enethiol…”
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Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases by Rose, Nathan R, Woon, Esther C. Y, Tumber, Anthony, Walport, Louise J, Chowdhury, Rasheduzzaman, Li, Xuan Shirley, King, Oliver N. F, Lejeune, Clarisse, Ng, Stanley S, Krojer, Tobias, Chan, Mun Chiang, Rydzik, Anna M, Hopkinson, Richard J, Che, Ka Hing, Daniel, Michelle, Strain-Damerell, Claire, Gileadi, Carina, Kochan, Grazyna, Leung, Ivanhoe K. H, Dunford, James, Yeoh, Kar Kheng, Ratcliffe, Peter J, Burgess-Brown, Nicola, von Delft, Frank, Muller, Susanne, Marsden, Brian, Brennan, Paul E, McDonough, Michael A, Oppermann, Udo, Klose, Robert J, Schofield, Christopher J, Kawamura, Akane

“…The JmjC oxygenases catalyze the N-demethylation of N ε-methyl lysine residues in histones and are current therapeutic targets. A set of human 2-oxoglutarate…”
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Use of ferrous iron by metallo-β-lactamases by Cahill, Samuel T., Tarhonskaya, Hanna, Rydzik, Anna M., Flashman, Emily, McDonough, Michael A., Schofield, Christopher J., Brem, Jürgen

“…Metallo-β-lactamases (MBLs) catalyse the hydrolysis of almost all β-lactam antibacterials including the latest generation carbapenems and are a growing…”
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Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates by Calvopiña, Karina, Umland, Klaus-Daniel, Rydzik, Anna M, Hinchliffe, Philip, Brem, Jürgen, Spencer, James, Schofield, Christopher J, Avison, Matthew B

“…Acetamido derivatives of the naturally antibacterial non-β-lactam lactivicin (LTV) have improved activity against their penicillin binding protein targets and…”
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Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis by Kamps, Jos J. A. G., Khan, Amjad, Choi, Hwanho, Lesniak, Robert K., Brem, Jürgen, Rydzik, Anna M., McDonough, Michael A., Schofield, Christopher J., Claridge, Timothy D. W., Mecinović, Jasmin

“…γ‐Butyrobetaine hydroxylase (BBOX) is a non‐heme FeII‐ and 2‐oxoglutarate‐dependent oxygenase that catalyzes the stereoselective hydroxylation of an…”
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Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1 by Brem, Jürgen, Struwe, Weston B., Rydzik, Anna M., Tarhonskaya, Hanna, Pfeffer, Inga, Flashman, Emily, van Berkel, Sander S., Spencer, James, Claridge, Timothy D. W., McDonough, Michael A., Benesch, Justin L. P., Schofield, Christopher J.

“…Metallo-β-lactamases (MBLs) catalyse the hydrolysis of almost all β-lactam antibiotics. We report biophysical and kinetic studies on the São Paulo MBL (SPM-1),…”
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