Search Results - "Ryder, W."

Second-line chemotherapy in advanced biliary cancer: a systematic review by Lamarca, A., Hubner, R.A., David Ryder, W., Valle, J.W.

“…The randomized NCRN phase III ABC-02 trial provided level-A evidence for first-line chemotherapy with cisplatin and gemcitabine combination in advanced biliary…”
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Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial by Lamarca, Angela, Palmer, Daniel H, Wasan, Harpreet Singh, Ross, Paul J, Ma, Yuk Ting, Arora, Arvind, Falk, Stephen, Gillmore, Roopinder, Wadsley, Jonathan, Patel, Kinnari, Anthoney, Alan, Maraveyas, Anthony, Iveson, Tim, Waters, Justin S, Hobbs, Claire, Barber, Safia, Ryder, W David, Ramage, John, Davies, Linda M, Bridgewater, John A, Valle, Juan W

“…Advanced biliary tract cancer has a poor prognosis. Cisplatin and gemcitabine is the standard first-line chemotherapy regimen, but no robust evidence is…”
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Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism by Jiang, Cheng, Hopfner, Franziska, Katsikoudi, Antigoni, Hein, Robert, Catli, Candan, Evetts, Samuel, Huang, Yongzhi, Wang, Hong, Ryder, John W, Kuhlenbaeumer, Gregor, Deuschl, Guenther, Padovani, Alessandro, Berg, Daniela, Borroni, Barbara, Hu, Michele T, Davis, Jason J, Tofaris, George K

“…ObjectiveParkinson’s disease is characterised neuropathologically by α-synuclein aggregation. Currently, there is no blood test to predict the underlying…”
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PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a Multi-Center, Randomized Double-Blind, Placebo-Controlled Phase III Trial by Kitson, Sarah J, Maskell, Zoe, Sivalingam, Vanitha N, Allen, Jennifer L, Ali, Saad, Burns, Sean, Gilmour, Kyle, Latheef, Rahamatulla, Slade, Richard J, Pemberton, Philip W, Shaw, Joseph, Ryder, W David, Kitchener, Henry C, Crosbie, Emma J

“…Endometrioid endometrial cancer is strongly associated with obesity and insulin resistance. Metformin, an insulin sensitizer, reduces endometrial tumor growth…”
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Acupuncture for Cancer-Related Fatigue in Patients With Breast Cancer: A Pragmatic Randomized Controlled Trial by MOLASSIOTIS, Alexander, BARDY, Joy, FINNEGAN-JOHN, Jennifer, MACKERETH, Peter, RYDER, David W, FILSHIE, Jacqueline, REAM, Emma, RICHARDSON, Alison

“…We aimed to assess the effectiveness of acupuncture for cancer-related fatigue (CRF) in patients with breast cancer. We conducted a pragmatic, randomized…”
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The use of thyroid function tests in the diagnosis of hypopituitarism: definition and evaluation of the TSH Index by Jostel, Andreas, Ryder, W. David J., Shalet, Stephen M.

“…Summary Background  TSH secretion in hypopituitary patients may be decreased due to TSH deficiency but it also remains under feedback inhibition by free…”
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A Phase II randomized controlled trial of oral prednisolone in early diffuse cutaneous systemic sclerosis (PRedSS) by Griffiths-Jones, Deborah J, Garcia, Yvonne Sylvestre, Ryder, W David, Pauling, John D, Hall, Frances, Lanyon, Peter, Bhat, Smita, Douglas, Karen, Gunawardena, Harsha, Akil, Mohammed, Anderson, Marina, Griffiths, Bridget, Del Galdo, Francesco, Youssef, Hazem, Madhok, Rajan, Arthurs, Barbara, Buch, Maya, Fligelstone, Kim, Zubair, Mohammed, Mason, Justin C, Denton, Christopher P, Herrick, Ariane L

“…Abstract Objectives Although the painful and disabling features of early diffuse cutaneous SSc (dcSSc) have an inflammatory basis and could respond to…”
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An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation by Smit, Linda, Berns, Katrien, Spence, Katherine, Ryder, W David, Zeps, Nik, Madiredjo, Mandy, Beijersbergen, Roderick, Bernards, René, Clarke, Robert B

“…Therapy resistance is one of the major impediments to successful cancer treatment. In breast cancer, a small subpopulation of cells with stem cell features,…”
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Physiological and Functional Alterations after Spaceflight and Bed Rest by MULAVARA, AJITKUMAR P, PETERS, BRIAN T, MILLER, CHRIS A, KOFMAN, IGOR S, RESCHKE, MILLARD F, TAYLOR, LAURA C, LAWRENCE, EMILY L, WOOD, SCOTT J, LAURIE, STEVEN S, LEE, STUART M C, BUXTON, ROXANNE E, MAY-PHILLIPS, TIFFANY R, STENGER, MICHAEL B, PLOUTZ-SNYDER, LORI L, RYDER, JEFFREY W, FEIVESON, ALAN H, BLOOMBERG, JACOB J

“…INTRODUCTIONExposure to microgravity causes alterations in multiple physiological systems, potentially impacting the ability of astronauts to perform critical…”
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Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry by Kellie, John F., Higgs, Richard E., Ryder, John W., Major, Anthony, Beach, Thomas G., Adler, Charles H., Merchant, Kalpana, Knierman, Michael D.

“…A robust top down proteomics method is presented for profiling alpha-synuclein species from autopsied human frontal cortex brain tissue from Parkinson's cases…”
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Multi-Maintenance Olaparib Therapy in Relapsed, Germline BRCA1/2-Mutant High-Grade Serous Ovarian Cancer (MOLTO): A Phase II Trial by Morgan, Robert D, Clamp, Andrew R, White, Daniel J, Price, Marcus, Burghel, George J, Ryder, W David J, Mahmood, Reem D, Murphy, Alexander D, Hasan, Jurjees, Mitchell, Claire L, Salih, Zena, Wheeler, Chelsey, Buckley, Emma, Truelove, Joanna, King, Georgia, Ainaoui, Yasmina, Bhaskar, Sanjeev S, Shaw, Joseph, Evans, D Gareth R, Kilerci, Bedirhan, Pearce, Simon P, Brady, Gerard, Dive, Caroline, O'Connor, James P B, Wallace, Andrew J, Rothwell, Dominic G, Edmondson, Richard J, Jayson, Gordon C

“…A single maintenance course of a PARP inhibitor (PARPi) improves progression-free survival (PFS) in germline BRCA1/2-mutant high-grade serous ovarian cancer…”
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A randomized, controlled trial of acupuncture self-needling as maintenance therapy for cancer-related fatigue after therapist-delivered acupuncture by Molassiotis, A., Bardy, J., Finnegan-John, J., Mackereth, P., Ryder, W.D., Filshie, J., Ream, E., Eaton, D., Richardson, A.

“…Maintenance acupuncture is advocated by clinicians after successful clinic-based acupuncture. We aimed to assess the effectiveness of maintenance acupuncture…”
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Prophylactic Irradiation of Tracts in Patients With Malignant Pleural Mesothelioma: An Open-Label, Multicenter, Phase III Randomized Trial by Bayman, Neil, Appel, Wiebke, Ashcroft, Linda, Baldwin, David R, Bates, Andrew, Darlison, Liz, Edwards, John G, Ezhil, Veni, Gilligan, David, Hatton, Matthew, Jegannathen, Apurna, Mansy, Talal, Peake, Michael D, Pemberton, Laura, Rintoul, Robert C, Snee, Michael, Ryder, W David, Taylor, Paul, Faivre-Finn, Corinne

“…Prophylactic irradiation to the chest wall after diagnostic or therapeutic procedures in patients with malignant pleural mesothelioma (MPM) has been a…”
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A randomised, pragmatic clinical trial of ACUpuncture plus standard care versus standard care alone FOr Chemotherapy Induced peripheral Neuropathy (ACUFOCIN) by Stringer, Jacqui, Ryder, W. David, Mackereth, Peter A., Misra, Vivek, Wardley, Andrew M.

“…Chemotherapy-induced peripheral neuropathy (CIPN) is a dose limiting toxicity posing a major clinical challenge for managing patients receiving specific…”
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Isotoxic Intensity Modulated Radiation Therapy in Stage III Non-Small Cell Lung Cancer: A Feasibility Study by Haslett, Kate, Bayman, Neil, Franks, Kevin, Groom, Nicki, Harden, Susan V., Harris, Catherine, Hanna, Gerard, Harrow, Stephen, Hatton, Matthew, McCloskey, Paula, McDonald, Fiona, Ryder, W. David, Faivre-Finn, Corinne

“…Not all patients with stage III non-small cell lung cancer (NSCLC) are suitable for concurrent chemoradiation therapy (CRT). Local failure rate is high for…”
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Is it time to convert the frequency of radiotherapy in small-cell lung cancer? – Authors' reply by Faivre-Finn, Corinne, Ryder, W David, Blackhall, Fiona

“…In the 489 patients treated with concurrent chemoradiotherapy, 45 (18%) of 254 patients treated with twice-daily radiotherapy and 36 (15%) of 235 treated with…”
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Panoramic ultrasound: a novel and valid tool for monitoring change in muscle mass by Scott, Jessica M., Martin, David S., Ploutz‐Snyder, Robert, Matz, Timothy, Caine, Timothy, Downs, Meghan, Hackney, Kyle, Buxton, Roxanne, Ryder, Jeffrey W., Ploutz‐Snyder, Lori

“…Background The strong link between reduced muscle mass and morbidity and mortality highlights the urgent need for simple techniques that can monitor change in…”
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Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer by CLAYTON, A. J, DANSON, S, HOWELL, A, WARDLEY, A. M, JOLLY, S, RYDER, W. D. J, BURT, P. A, STEWART, A. L, WILKINSON, P. M, WELCH, R. S, MAGEE, B, WILSON, G

“…Trastuzumab is an effective treatment for patients with metastatic breast cancer (MBC) that overexpresses HER-2. A high incidence of brain metastases (BM) has…”
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The Effectiveness of Acupressure for the Control and Management of Chemotherapy-Related Acute and Delayed Nausea: A Randomized Controlled Trial by Molassiotis, Alexander, RN, BN, MSc, PhD, Russell, Wanda, BSc (Hons), PhD, Hughes, John, PhD, Breckons, Matthew, BSc (Hons), Lloyd-Williams, Mari, MD, FRCP, FRCGP, Richardson, Janet, BSc (Hons), PhD, Hulme, Claire, BSc (Hons), MA, PhD, Brearley, Sarah G., BSc (Hons), PhD, Campbell, Malcolm, BSc, MSc, PhD, Garrow, Adam, MSc, PhD, Ryder, W. David, BSc (Hons), Grad. IS

“…Abstract Context Both positive and negative results have been reported in the literature from the use of acupressure at the P6 point, providing evidence of…”
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Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model by Wang, Hong, Li, Yupeng, Ryder, John W, Hole, Justin T, Ebert, Philip J, Airey, David C, Qian, Hui-Rong, Logsdon, Benjamin, Fisher, Alice, Ahmed, Zeshan, Murray, Tracey K, Cavallini, Annalisa, Bose, Suchira, Eastwood, Brian J, Collier, David A, Dage, Jeffrey L, Miller, Bradley B, Merchant, Kalpana M, O'Neill, Michael J, Demattos, Ronald B

“…Activation of microglia, the resident immune cells of the central nervous system, is a prominent pathological hallmark of Alzheimer's disease (AD). However,…”
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