Search Results - "Rydberg, Edwin H."

FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded by Prilusky, Jaime, Felder, Clifford E., Zeev-Ben-Mordehai, Tzviya, Rydberg, Edwin H., Man, Orna, Beckmann, Jacques S., Silman, Israel, Sussman, Joel L.

“…An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described: it predicts if a given protein sequence is intrinsically unfolded…”
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Complexes of Alkylene-Linked Tacrine Dimers with Torpedo californica Acetylcholinesterase:  Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge by RYDBERG, Edwin H., BRUMSHTEIN, Boris, GREENBLATT, Harry M., WONG, Dawn M., SHAYA, David, WILLIAMS, Larry D., CARLIER, Paul R., PANG, Yuan-Ping, SILMAN, Israel, SUSSMAN, Joel L.

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Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors by Ontoria, Jesus M, Rydberg, Edwin H, Di Marco, Stefania, Tomei, Licia, Attenni, Barbara, Malancona, Savina, Martin Hernando, José I, Gennari, Nadia, Koch, Uwe, Narjes, Frank, Rowley, Michael, Summa, Vincenzo, Carroll, Steve S, Olsen, David B, De Francesco, Raffaele, Altamura, Sergio, Migliaccio, Giovanni, Carfì, Andrea

“…The hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian…”
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Subsite Mapping of the Human Pancreatic α-Amylase Active Site through Structural, Kinetic, and Mutagenesis Techniques by Brayer, Gary D, Sidhu, Gary, Maurus, Robert, Rydberg, Edwin H, Braun, Curtis, Wang, Yili, Nguyen, Nham T, Overall, Christopher M, Withers, Stephen G

“…We report a multifaceted study of the active site region of human pancreatic α-amylase. Through a series of novel kinetic analyses using malto-oligosaccharides…”
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Mechanistic Analyses of Catalysis in Human Pancreatic α-Amylase:  Detailed Kinetic and Structural Studies of Mutants of Three Conserved Carboxylic Acids by Rydberg, Edwin H, Li, Chunmin, Maurus, Robert, Overall, Christopher M, Brayer, Gary D, Withers, Stephen G

“…The roles of three conserved active site carboxylic acids (D197, E233, and D300) in the catalytic mechanism of human pancreatic α-amylase (HPA) were studied by…”
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Structural Basis for Resistance of the Genotype 2b Hepatitis C Virus NS5B Polymerase to Site A Non-Nucleoside Inhibitors by Rydberg, Edwin H., Cellucci, Antonella, Bartholomew, Linda, Mattu, Marco, Barbato, Gaetano, Ludmerer, Steven W., Graham, Donald J., Altamura, Sergio, Paonessa, Giacomo, De Francesco, Raffaele, Migliaccio, Giovanni, Carfí, Andrea

“…Hepatitis C virus (HCV) exists in six major genotypes. Compared with the 1b enzyme, genotype 2b HCV polymerase exhibits a more than 100-fold reduction in…”
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The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded by Zeev-Ben-Mordehai, Tzviya, Rydberg, Edwin H., Solomon, Ariel, Toker, Lilly, Auld, Vanessa J., Silman, Israel, Botti, Simone, Sussman, Joel L.

“…Drosophila gliotactin (Gli) is a 109‐kDa transmembrane, cholinesterase‐like adhesion molecule (CLAM), expressed in peripheral glia, that is crucial for…”
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Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: Over-expression, purification and biophysical characterization by Zeev-Ben-Mordehai, Tzviya, Paz, Aviv, Peleg, Yoav, Toker, Lilly, Wolf, Sharon G., Rydberg, Edwin H., Sussman, Joel L., Silman, Israel

“…Amalgam, a multi-domain member of the immunoglobulin superfamily, possesses homophilic and heterophilic cell adhesion properties. It is required for axon…”
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Complexes of Alkylene-Linked Tacrine Dimers with Torpedo c alifornica Acetylcholinesterase:  Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge by Rydberg, Edwin H, Brumshtein, Boris, Greenblatt, Harry M, Wong, Dawn M, Shaya, David, Williams, Larry D, Carlier, Paul R, Pang, Yuan-Ping, Silman, Israel, Sussman, Joel L

“…The X-ray crystal structures were solved for complexes with Torpedo californica acetylcholinesterase of two bivalent tacrine derivative compounds in which the…”
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An Anomalous Reaction of 2-Benzenesulfonyl-3-aryloxaziridines (Davis Reagents) with Indoles:  Evidence for a Stepwise Reaction of the Davis Reagent with a π-Bond by Mithani, Salim, Drew, David M, Rydberg, Edwin H, Taylor, Nicholas J, Mooibroek, Sandra, Dmitrienko, Gary I

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Identification and Biological Evaluation of a Series of 1 H -Benzo[ de ]isoquinoline-1,3(2 H )-diones as Hepatitis C Virus NS5B Polymerase Inhibitors by Ontoria, Jesus M., Rydberg, Edwin H., Di Marco, Stefania, Tomei, Licia, Attenni, Barbara, Malancona, Savina, Martin Hernando, José I., Gennari, Nadia, Koch, Uwe, Narjes, Frank, Rowley, Michael, Summa, Vincenzo, Carroll, Steve S., Olsen, David B., De Francesco, Raffaele, Altamura, Sergio, Migliaccio, Giovanni, Carfì, Andrea

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Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge by Rydberg, Edwin H, Brumshtein, Boris, Greenblatt, Harry M, Wong, Dawn M, Shaya, David, Williams, Larry D, Carlier, Paul R, Pang, Yuan-Ping, Silman, Israel, Sussman, Joel L

“…The X-ray crystal structures were solved for complexes with Torpedo californica acetylcholinesterase of two bivalent tacrine derivative compounds in which the…”
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Cloning, mutagenesis, and structural analysis of human pancreatic α-amylase expressed in Pichia pastoris by RYDBERG, EDWIN H., SIDHU, GARY, VO, HUNG C., HEWITT, JEFF, CÔTÉ, HÉLÈNE C.F., WANG, YILI, NUMAO, SHIN, MacGILLIVRAY, ROSS T.A., OVERALL, CHRISTOPHER M., BRAYER, GARY D., WITHERS, STEPHEN G.

“…Human pancreatic α-amylase (HPA) was expressed in the methylotrophic yeast Pichia pastoris and two mutants (D197A and D197N) of a completely conserved active…”
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Detection of intracellular calcium elevations in Xenopus laevis oocytes: aequorin luminescence versus electrophysiology by Grygorczyk, Ryszard, Feighner, Scott D., Adam, Mohammed, Liu, Ken K., LeCouter, Jennifer E., Dashkevicz, Michael P., Hreniuk, Donna L., Rydberg, Edwin H., Arena, Joseph P.

“…Detection of receptor expression in Xenopus oocytes often relies upon functional coupling to second messengers such as Ca 2+ or cyclic adenosine monophosphate…”
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