Search Results - "Rychlowski, Michal"
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Tunneling Nanotubes as a Novel Route of Cell-to-Cell Spread of Herpesviruses
Published in Journal of virology (15-05-2018)“…Various types of intercellular connections that are essential for communication between cells are often utilized by pathogens. Recently, a new type of cellular…”
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Photoactivated Gallium Porphyrin Reduces Staphylococcus aureus Colonization on the Skin and Suppresses Its Ability to Produce Enterotoxin C and TSST‑1
Published in Molecular pharmaceutics (02-10-2023)“…Staphylococcus aureus is a key pathogen in atopic dermatitis (AD) pathogenicity. Over half of AD patients are carriers of S. aureus. Clinical isolates derived…”
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The PKGIα–Rac1 pathway is a novel regulator of insulin‐dependent glucose uptake in cultured rat podocytes
Published in Journal of cellular physiology (01-06-2021)“…Insulin plays a major role in regulating glucose homeostasis in podocytes. Protein kinase G type Iα (PKGIα) plays an important role in regulating glucose…”
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Extracellular ATP modulates podocyte function through P2Y purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA signaling pathways
Published in Archives of biochemistry and biophysics (30-11-2020)“…Podocytes and their foot processes interlinked by slit diaphragms, constitute a continuous outermost layer of the glomerular capillary and seem to be crucial…”
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Radiosensitization of PC3 Prostate Cancer Cells by 5-Thiocyanato-2'-deoxyuridine
Published in Cancers (18-04-2022)“…The radiosensitizing properties of uracil analogs modified in the C5 position are very interesting in the context of their effectiveness and safety in…”
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6
Emerin mislocalization during chromatin bridge resolution can drive prostate cancer cell invasiveness in a collagen-rich microenvironment
Published in Experimental & molecular medicine (01-09-2024)“…Micronuclei (MN) can form through many mechanisms, including the breakage of aberrant cytokinetic chromatin bridges. The frequent observation of MN in tumors…”
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PTEN-induced kinase 1 deficiency alters albumin permeability and insulin signaling in podocytes
Published in Journal of molecular medicine (Berlin, Germany) (01-06-2022)“…Alterations of insulin signaling in diabetes are associated with podocyte injury, proteinuria, and renal failure. Insulin stimulates glucose transport to cells…”
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Consequences of lysine auxotrophy for Candida albicans adherence and biofilm formation
Published in Acta biochimica Polonica (01-01-2017)“…A number of factors are known to be involved in Candida albicans virulence, although biofilm development on the surfaces of indwelling medical devices is…”
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Antibacterial Activity of Co(III) Complexes with Diamine Chelate Ligands against a Broad Spectrum of Bacteria with a DNA Interaction Mechanism
Published in Pharmaceutics (24-06-2021)“…Cobalt coordination complexes are very attractive compounds for their therapeutic uses as antiviral, antibacterial, antifungal, antiparasitic, or antitumor…”
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Insulin increases filtration barrier permeability via TRPC6-dependent activation of PKGIα signaling pathways
Published in Biochimica et biophysica acta. Molecular basis of disease (01-06-2017)“…Podocytes are dynamic polarized cells on the surface of glomerular capillaries and an essential component of the glomerular filtration barrier. Insulin…”
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New Oxidovanadium(IV) Coordination Complex Containing 2-Methylnitrilotriacetate Ligands Induces Cell Cycle Arrest and Autophagy in Human Pancreatic Ductal Adenocarcinoma Cell Lines
Published in International journal of molecular sciences (10-01-2019)“…Pancreatic cancer is characterized by one of the lowest five-year survival rates. In search for new treatments, some studies explored several metal complexes…”
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The HtrA3 protease promotes drug‐induced death of lung cancer cells by cleavage of the X‐linked inhibitor of apoptosis protein (XIAP)
Published in The FEBS journal (01-11-2019)“…HtrA3 is a proapoptotic protease shown to promote drug‐induced cytotoxicity in lung cancer cells and proposed to have an antitumor effect. However, at the…”
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Implementation of a Non-Thermal Atmospheric Pressure Plasma for Eradication of Plant Pathogens from a Surface of Economically Important Seeds
Published in International journal of molecular sciences (26-08-2021)“…Plant pathogenic bacteria cause significant economic losses in the global food production sector. To secure an adequate amount of high-quality nutrition for…”
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14
Mitochondrial DNA Copy Number in Cleavage Stage Human Embryos-Impact on Infertility Outcome
Published in Current issues in molecular biology (09-01-2022)“…A retrospective case control study was undertaken at the molecular biology department of a private center for reproductive medicine in order to determine…”
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Colonization of potato rhizosphere by GFP-tagged Bacillus subtilis MB73/2, Pseudomonas sp. P482 and Ochrobactrum sp. A44 shown on large sections of roots using enrichment sample preparation and confocal laser scanning microscopy
Published in Sensors (Basel, Switzerland) (18-12-2012)“…The ability to colonize the host plants' rhizospheres is a crucial feature to study in the case of Plant Growth Promoting Rhizobacteria (PGPRs) with potential…”
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HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death
Published in Cells (Basel, Switzerland) (20-09-2019)“…The HtrA4 human protease is crucial in placentation and embryo implantation, and its altered level is connected with pre-eclampsia. The meta-analyses of…”
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Modulation of acridine mutagen ICR191 intercalation to DNA by methylxanthines—Analysis with mathematical models
Published in Bioorganic & medicinal chemistry (01-06-2013)“…Hetero-complexation of acridine mutagen ICR191 with caffeine leads to substantial decrease in mutagen free form and its partial de-intercalation from DNA…”
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Interactions of newly synthesized platinum nanoparticles with ICR-191 and their potential application
Published in Scientific reports (21-03-2019)“…One of the greatest challenges of modern medicine is to find cheaper and easier ways to produce transporters for biologically active substances, which will…”
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Optimization of Streptococcus agalactiae Biofilm Culture in a Continuous Flow System for Photoinactivation Studies
Published in Pathogens (Basel) (18-09-2021)“…is a relevant cause of neonatal mortality. It can be transferred to infants via the vaginal tract and cause meningitis, pneumonia, arthritis, or sepsis, among…”
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Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2‐dependent fashion
Published in Journal of extracellular vesicles (01-06-2023)“…Filaggrin (FLG) protein is indispensable for multiple aspects of the epidermal barrier function but its accumulation in a monomeric filaggrin form may initiate…”
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