Search Results - "Rychak, J J"

Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow by Takalkar, Amol M, Klibanov, Alexander L, Rychak, Joshua J, Lindner, Jonathan R, Ley, Klaus

“…This study was performed to assess the binding kinetics of a targeted microbubble contrast agent exposed to shear stress. An ultrasound contrast targeted to…”
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Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow by Ferrante, E.A., Pickard, J.E., Rychak, J., Klibanov, A., Ley, K.

“…To improve ultrasound contrast agents targeted to the adhesion molecules P-selectin and VCAM-1 for the purpose of molecular imaging of atherosclerotic plaques,…”
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scVEGF Microbubble Ultrasound Contrast Agents: A Novel Probe for Ultrasound Molecular Imaging of Tumor Angiogenesis by Anderson, Christopher R, Rychak, Joshua J, Backer, Marina, Backer, Joseph, Ley, Klaus, Klibanov, Alexander L

“…OBJECTIVE:To develop a novel microbubble (MB) ultrasound contrast agent covalently coupled to a recombinant single-chain vascular endothelial growth factor…”
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Molecular ultrasound imaging using microbubble contrast agents by Dayton, Paul A, Rychak, Joshua J

“…Molecular imaging is a new field in bioscience which, by virtue of utilizing a contrast agent or reporter, facilitates early detection of the disease processes…”
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Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow by Klibanov, A L, Rychak, J J, Yang, W C, Alikhani, S, Li, B, Acton, S, Lindner, J R, Ley, K, Kaul, S

“…Targeted ultrasound contrast materials (gas-filled microbubbles carrying ligands to endothelial selectins or integrins) have been investigated as potential…”
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Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease by Tlaxca, José L., Rychak, Joshua J., Ernst, Peter B., Konkalmatt, Prasad R., Shevchenko, Talent I., Pizzaro, Theresa T., Rivera-Nieves, Jesús, Klibanov, Alexander L., Lawrence, Michael B.

“…Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract (GI) for which treatments with immunosuppressive drugs have significant…”
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A novel method for quantitative myocardial contrast echocardiography in mice by Alvarez, E, Dalton, N D, Gu, Y, Smith, D, Luong, A, Hoshijima, M, Peterson, K L, Rychak, J

“…The small size of the mouse heart frequently imparts technical challenges when applying conventional in vivo imaging methods for assessing heart function…”
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Enhanced Targeting of Ultrasound Contrast Agents Using Acoustic Radiation Force by Rychak, Joshua J, Klibanov, Alexander L, Ley, Klaus F, Hossack, John A

“…Abstract Contrast-enhanced ultrasound has shown significant promise as a molecular imaging modality. However, one potential drawback is the difficulty that…”
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Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification by Rychak, J.J., Klibanov, A.L., Hossack, J.A.

“…Recent research has shown that targeted ultrasound contrast microbubbles achieve specific adhesion to regions of intravascular pathology, but not in areas of…”
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Analysis of in vitro Transfection by Sonoporation Using Cationic and Neutral Microbubbles by Tlaxca, Jose L, Anderson, Christopher R, Klibanov, Alexander L, Lowrey, Bryce, Hossack, John A, Alexander, J. Steven, Lawrence, Michael B, Rychak, Joshua J

“…Abstract The objective of the study was to examine the role of acoustic power intensity and microbubble and plasmid concentrations on transfection efficiency…”
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Microultrasound Molecular Imaging of Vascular Endothelial Growth Factor Receptor 2 in a Mouse Model of Tumor Angiogenesis by Rychak, Joshua J., Graba, James, Cheung, Alison M.Y., Mystry, Bina S., Lindner, Jonathan R., Kerbel, Robert S., Foster, F. Stuart

“…High-frequency microultrasound imaging of tumor progression in mice enables noninvasive anatomic and functional imaging at excellent spatial and temporal…”
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Real-Time Technique for Improving Molecular Imaging and Guiding Drug Delivery in Large Blood Vessels: In Vitro and Ex Vivo Results by Patil, Abhay V., Rychak, Joshua J., Klibanov, Alexander L., Hossack, John A.

“…Ultrasound-based molecular imaging employs targeted microbubbles to image vascular pathology. This approach also has the potential to monitor molecularly…”
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Dual Frequency Method for Simultaneous Translation and Real-Time Imaging of Ultrasound Contrast Agents Within Large Blood Vessels by Patil, Abhay V, Rychak, Joshua J, Allen, John S, Klibanov, Alexander L, Hossack, John A

“…Abstract A dual frequency excitation method for simultaneous translation and selective real-time imaging of microbubbles is presented. The method can…”
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Nucleic acid delivery with microbubbles and ultrasound by Rychak, Joshua J., Klibanov, Alexander L.

“…Nucleic acid-based therapy is a growing field of drug delivery research. Although ultrasound has been suggested to enhance transfection decades ago, it took a…”
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Selectin Ligands Promote Ultrasound Contrast Agent Adhesion under Shear Flow by Rychak, J. J, Li, B, Acton, S. T, Leppänen, A, Cummings, R. D, Ley, K, Klibanov, A. L

“…Contrast-enhanced ultrasound imaging has shown promise in the field of molecular imaging. This technique relies upon the adhesion of ultrasound contrast agent…”
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Ultrasound Molecular Imaging of Tumor Angiogenesis With an Integrin Targeted Microbubble Contrast Agent by Anderson, Christopher R, Hu, Xiaowen, Zhang, Hua, Tlaxca, Jose, Declèves, Anne-Emilie, Houghtaling, Robert, Sharma, Kumar, Lawrence, Michael, Ferrara, Katherine W, Rychak, Joshua J

“…RATIONALE AND OBJECTIVES:Ultrasound molecular imaging is an emerging technique for sensitive detection of intravascular targets. Molecular imaging of…”
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WE‐D‐210‐02: Design and Development of Ultrasound Contrast Agents for Molecular Imaging by Rychak, J.

“…The utilization of ultrasound contrast agents offers significant promise in enhancing the diagnostic capabilities of ultrasound imaging as well as offering…”
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Development of a Translatable Ultrasound Molecular Imaging Agent for Inflammation by Luong, Alice, Smith, Dan, Tai, Chia-Hung, Cotter, Bruno, Luo, Colin, Strachan, Monet, DeMaria, Anthony, Rychak, Joshua J.

“…This study details the development, characterization and non-clinical efficacy of an ultrasound molecular imaging agent intended for molecular imaging of…”
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Targeted renal therapies through microbubbles and ultrasound by Deelman, Leo E., Declèves, Anne-Emilie, Rychak, Joshua J., Sharma, Kumar

“…Microbubbles and ultrasound enhance the cellular uptake of drugs (including gene constructs) into the kidney. Microbubble induced modifications to the size…”
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Short Hairpin RNA Knockdown of Connective Tissue Growth Factor by Ultrasound-Targeted Microbubble Destruction Improves Renal Fibrosis by Wei, Shuping, Xu, Chaoli, Rychak, Joshua J, Luong, Alice, Sun, Yu, Yang, Zhijian, Li, Mingxia, Liu, Chunrui, Fu, Ninghua, Yang, Bin

“…Abstract The purpose of this study was to evaluate whether ultrasound-targeted microbubble destruction transfer of interfering RNA against connective tissue…”
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