Search Results - "Ryberg, Line A"
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Oligomerization of a Glucagon-like Peptide 1 Analog: Bridging Experiment and Simulations
Published in Biophysical journal (15-09-2015)“…The glucagon-like peptide 1 (GLP-1) analog, liraglutide, is a GLP-1 agonist and is used in the treatment of type-2 diabetes mellitus and obesity. From a…”
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Overcoming culture restriction for SARS-CoV-2 in human cells facilitates the screening of compounds inhibiting viral replication
Published in Antimicrobial agents and chemotherapy (17-06-2021)“…Efforts to mitigate the COVID-19 pandemic include screening of existing antiviral molecules that could be re-purposed to treat SARS-CoV-2 infections. Although…”
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Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide‐Activated Sirtuin 7
Published in Angewandte Chemie International Edition (04-12-2023)“…The sirtuins are NAD+‐dependent lysine deacylases, comprising seven isoforms (SIRT1–7) in humans, which are involved in the regulation of a plethora of…”
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Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide
Published in Nature (London) (27-07-2023)“…RNA viruses have evolved elaborate strategies to protect their genomes, including 5′ capping. However, until now no RNA 5′ cap has been identified for…”
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Investigations of Albumin–Insulin Detemir Complexes Using Molecular Dynamics Simulations and Free Energy Calculations
Published in Molecular pharmaceutics (06-01-2020)“…Insulin detemir is a lipidated insulin analogue that obtains a half-life extension by oligomerization and reversible binding to human serum albumin. In the…”
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Solution structures of long‐acting insulin analogues and their complexes with albumin
Published in Acta crystallographica. Section D, Biological crystallography. (01-03-2019)“…The lipidation of peptide drugs is one strategy to obtain extended half‐lives, enabling once‐daily or even less frequent injections for patients. The half‐life…”
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Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide‐Activated Sirtuin 7
Published in Angewandte Chemie (04-12-2023)“…The sirtuins are NAD+‐dependent lysine deacylases, comprising seven isoforms (SIRT1–7) in humans, which are involved in the regulation of a plethora of…”
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Journal Article