Search Results - "Rybaczek, Dorota"

Hydroxyurea and Caffeine Impact pRb-like Protein-Dependent Chromatin Architecture Profiles in Interphase Cells of Vicia faba by Musiałek, Marcelina W, Deckert, Joanna, Rybaczek, Dorota

“…The survival of cells depends on their ability to replicate correctly genetic material. Cells exposed to replication stress can experience a number of problems…”
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The Role of Lysine-Specific Demethylase 1 (LSD1) in Shaping the Endothelial Inflammatory Response by Wojtala, Martyna, Rybaczek, Dorota, Wielgus, Ewelina, Sobalska-Kwapis, Marta, Strapagiel, Dominik, Balcerczyk, Aneta

“…Inflammation is the body's natural response to stress in the broadest sense. The regulatory mechanisms that control this process, some of which are still…”
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Behavior of replication origins in Eukaryota - spatio-temporal dynamics of licensing and firing by Musiałek, Marcelina W, Rybaczek, Dorota

“…Although every organism shares some common features of replication, this process varies greatly among eukaryotic species. Current data show that mathematical…”
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Caffeine-Induced Premature Chromosome Condensation Results in the Apoptosis-Like Programmed Cell Death in Root Meristems of Vicia faba by Rybaczek, Dorota, Musiałek, Marcelina Weronika, Balcerczyk, Aneta

“…We have demonstrated that the activation of apoptosis-like programmed cell death (AL-PCD) was a secondary result of caffeine (CF) induced premature chromosome…”
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The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous BRCAMUT and BRCAWT Ovarian Cancer Cells by Gralewska, Patrycja, Gajek, Arkadiusz, Rybaczek, Dorota, Marczak, Agnieszka, Rogalska, Aneta

“…Olaparib is a poly (ADP-ribose) polymerase inhibitor (PARPi) that inhibits PARP1/2, leading to replication-induced DNA damage that requires homologous…”
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Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells by Wojtala, Martyna, Dąbek, Arkadiusz, Rybaczek, Dorota, Śliwińska, Agnieszka, Świderska, Ewa, Słapek, Katarzyna, El-Osta, Assam, Balcerczyk, Aneta

“…The methylation of histone lysine residues modifies chromatin conformation and regulates the expression of genes implicated in cell metabolism. Lysine-specific…”
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Kinetics of DNA Repair in Vicia faba Meristem Regeneration Following Replication Stress by Rybaczek, Dorota, Musiałek, Marcelina W, Vrána, Jan, Petrovská, Beáta, Pikus, Ewa G, Doležel, Jaroslav

“…The astonishing survival abilities of , one the earliest domesticated plants, are associated, among other things, to the highly effective replication stress…”
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Hydroxyurea-induced replication stress causes poly(ADP-ribose) polymerase-2 accumulation and changes its intranuclear location in root meristems of Vicia faba by Rybaczek, Dorota

“…Replication stress induced by 24 and 48h exposure to 2.5mM hydroxyurea (HU) increased the activity of poly(ADP-ribose) polymerase-2 (PARP-2; EC 2.4.2.30) in…”
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Ultrastructural changes associated with the induction of premature chromosome condensation in Vicia faba root meristem cells by Rybaczek, Dorota

“…KEY MESSAGE : PCC induction is regulated by several signaling pathways, and all observed effects associated with PCC induction are strongly dependent on the…”
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Replication and re-replication: Different implications of the same mechanism by Mazurczyk, Michalina, Rybaczek, Dorota

“…Replication is a process which provides two copies of genetic material to a mother cell that are essential for passing complete genetic information to daughter…”
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Hydroxyurea-The Good, the Bad and the Ugly by Musiałek, Marcelina W, Rybaczek, Dorota

“…Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR) and as the agent that is commonly used to arrest cells in the S-phase…”
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Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells by Wojtala, Martyna, Macierzyńska-Piotrowska, Ewa, Rybaczek, Dorota, Pirola, Luciano, Balcerczyk, Aneta

“…[Display omitted] Epigenetic mechanisms, including histone post-translational modifications, are central regulators of cell cycle control. The euchromatic G9a…”
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Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements by Rybaczek, Dorota, Kowalewicz-Kulbat, Magdalena

“…Here, we demonstrate that in HeLa cells, Ser317 of Chk1 undergoes phosphorylation in response to replication stress induced by hydroxyurea. We also demonstrate…”
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Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells by Balcerczyk, Aneta, Rybaczek, Dorota, Wojtala, Martyna, Pirola, Luciano, Okabe, Jun, El-Osta, Assam

“…[Display omitted] Posttranslational modifications of histone tails can alter chromatin structure and regulate gene transcription. While recent studies…”
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H2AX foci in late S/G2- and M-phase cells after hydroxyurea- and aphidicolin-induced DNA replication stress in Vicia by Rybaczek, Dorota, Bodys, Aleksandra, Maszewski, Janusz

“…Immunocytochemistry using alpha-phospho-H2AX antibodies shows that hydroxyurea (HU), an inhibitor of ribonucleotide reductase, and aphidicolin (APH), an…”
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Caffeine-Induced Premature Chromosome Condensation Results in the Apoptosis-Like Programmed Cell Death in Root Meristems of Vicia faba: e0142307 by Rybaczek, Dorota, Musialek, Marcelina Weronika, Balcerczyk, Aneta

“…We have demonstrated that the activation of apoptosis-like programmed cell death (AL-PCD) was a secondary result of caffeine (CF) induced premature chromosome…”
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Phosphorylation of H2AX histones in response to double-strand breaks and induction of premature chromatin condensation in hydroxyurea-treated root meristem cells of Raphanus sativus, Vicia faba, and Allium porrum by Rybaczek, Dorota, Maszewski, Janusz

“…Histone H2A variant H2AX is rapidly phosphorylated on the induction of DNA double-strand breaks by ionizing radiation and hydroxyurea-mediated replication…”
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Various chemical agents can induce premature chromosome condensation in Vicia faba by Rybaczek, Dorota, Żabka, Aneta, Pastucha, Anna, Maszewski, Janusz

“…A number of chemical agents known to influence the key cell cycle regulatory factors were used to assess the requirements of hydroxyurea-treated root meristem…”
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Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium by Balcerczyk, Aneta, Soszynski, Mirosław, Rybaczek, Dorota, Przygodzki, Tomasz, Karowicz-Bilinska, Agata, Maszewski, Janusz, Bartosz, Grzegorz

“…Diphenyleneiodonium (DPI) inhibits activity of flavoenzymes like NAD(P)H oxidase, the major source of superoxide anion in cardiovascular system, but affects…”
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Induction of premature mitosis in root meristem cells of Vicia faba and Pisum sativum by various agents is correlated with an increased level of protein phosphorylation by Rybaczek, Dorota, Polit, Justyna, Luchniak, Piotr, Maszewski, Janusz

“…The intra-S-phase checkpoint response to hydroxyurea (HU)-mediated arrest of DNA replication was analysed in root meristems of two legumes, Pisum sativum and…”
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