Myostatin - a modern understanding of the physiological role and significance in the development of age-associated diseases.

Myostatin is a protein belonging to the myokine class, the family of transforming growth factors β (TGF-β). The review article, based on the analysis of literature data, shows the key role of myostatin in the development of senile sarcopenia and cachexia in various pathological conditions, such as c...

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Bibliographic Details
Published in:	Advances in gerontology = Uspekhi gerontologii Vol. 34; no. 5; p. 701
Main Authors:	Gazdanova, A A, Kukes, V G, Parfenova, O K, Sidorov, N G, Perkov, A V, Solovieva, S A, Ryazantceva, O V, Lenkova, N I
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2021
Subjects:	Cachexia Cell Differentiation Humans Muscle, Skeletal - pathology Myostatin Sarcopenia Transforming Growth Factor beta myokines myostatin cachexia senile sarcopenia
Online Access:	Get more information
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Summary:	Myostatin is a protein belonging to the myokine class, the family of transforming growth factors β (TGF-β). The review article, based on the analysis of literature data, shows the key role of myostatin in the development of senile sarcopenia and cachexia in various pathological conditions, such as cancer, chronic heart failure, chronic renal failure, COPD, etc. The article discusses the structure of myostatin, provides a detailed diagram of the synthesis and activation of myostatin, the ways of implementing the mechanism of action as a negative regulator of muscle growth and differentiation in these pathological conditions. The main physiological properties and clinical significance are highlighted. Exogenous and endogenous factors regulating myostatin expression and possible mechanisms of their action are considered.
ISSN:	1561-9125