Search Results - "Ryan, Zachary C."

A Randomized Trial of the Effects of Dietary n3-PUFAs on Skeletal Muscle Function and Acute Exercise Response in Healthy Older Adults by Kunz, Hawley E, Michie, Kelly L, Gries, Kevin J, Zhang, Xiaoyan, Ryan, Zachary C, Lanza, Ian R

“…Skeletal muscle is critical for maintaining mobility, independence, and metabolic health in older adults. However, a common feature of aging is the progressive…”
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Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium by Ryan, Zachary C., Ketha, Hemamalini, McNulty, Melissa S., McGee-Lawrence, Meghan, Craig, Theodore A., Grande, Joseph P., Westendorf, Jennifer J., Singh, Ravinder J., Kumar, Rajiv

“…Inactivating mutations of the SOST (sclerostin) gene are associated with overgrowth and sclerosis of the skeleton. To determine mechanisms by which increased…”
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The Structure of the Human Centrin 2-Xeroderma Pigmentosum Group C Protein Complex by Thompson, James R., Ryan, Zachary C., Salisbury, Jeffrey L., Kumar, Rajiv

“…Human centrin-2 plays a key role in centrosome function and stimulates nucleotide excision repair by binding to the xeroderma pigmentosum group C protein. To…”
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Pathways for Extracellular Fenton Chemistry in the Brown Rot Basidiomycete Gloeophyllum trabeum by JENSEN, Kenneth A, HOUTMAN, Carl J, RYAN, Zachary C, HAMMEL, Kenneth E

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Extramyocellular interleukin‐6 influences skeletal muscle mitochondrial physiology through canonical JAK/STAT signaling pathways by Abid, Hinnah, Ryan, Zachary C., Delmotte, Philippe, Sieck, Gary C., Lanza, Ian R.

“…Interleukin‐6 (IL‐6) is a pleiotropic cytokine that has been shown to be produced acutely by skeletal muscle in response to exercise, yet chronically elevated…”
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1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells by Ryan, Zachary C., Craig, Theodore A., Folmes, Clifford D., Wang, Xuewei, Lanza, Ian R., Schaible, Niccole S., Salisbury, Jeffrey L., Nair, K. Sreekumaran, Terzic, Andre, Sieck, Gary C., Kumar, Rajiv

“…Muscle weakness and myopathy are observed in vitamin D deficiency and chronic renal failure, where concentrations of the active vitamin D3 metabolite,…”
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The secretome of senescent preadipocytes influences the phenotype and function of cells of the vascular wall by Parvizi, Mojtaba, Ryan, Zachary C., Ebtehaj, Sanam, Arendt, Bonnie K., Lanza, Ian R.

“…Senescent cells accumulate in numerous tissues in several chronic conditions such as aging, obesity, and diabetes. These cells are in a state of irreversible…”
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An NADH:Quinone Oxidoreductase Active during Biodegradation by the Brown-Rot Basidiomycete Gloeophyllum trabeum by JENSEN, Kenneth A, RYAN, Zachary C, WYMELENBERG, Amber Vanden, CULLEN, Daniel, HAMMEL, Kenneth E

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3 by Ryan, Zachary C., Craig, Theodore A., Filoteo, Adelaida G., Westendorf, Jennifer J., Cartwright, Elizabeth J., Neyses, Ludwig, Strehler, Emanuel E., Kumar, Rajiv

“…The physiological importance of the intestinal plasma membrane calcium pump, isoform 1, (Pmca1, Atp2b1), in calcium absorption and homeostasis has not been…”
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Identification of a Myosin VII-Talin Complex by Tuxworth, Richard I., Stephens, Stephen, Ryan, Zachary C., Titus, Margaret A.

“…Myosin VII (M7) plays a role in adhesion in both Dictyostelium and mammalian cells where it is a component of a complex of proteins that serve to link membrane…”
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1α,25-dihydroxyvitamin D3 mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells by Ryan, Zachary C., Craig, Theodore A., Wang, Xuewei, Delmotte, Philippe, Salisbury, Jeffrey L., Lanza, Ian R., Sieck, Gary C., Kumar, Rajiv

“…Cancer cachexia is associated with muscle weakness and atrophy. We investigated whether 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), which has previously been…”
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Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults by Hart, Corey R, Ryan, Zachary C, Pfaffenbach, Kyle T, Dasari, Surendra, Parvizi, Mojtaba, Lalia, Antigoni Z, Lanza, Ian R

“…Sarcopenia is linked with impaired adaptive responses to exercise in aging skeletal muscle. The unfolded protein response (UPR) is an important…”
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Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification by McGee-Lawrence, Meghan E., Ryan, Zachary C., Carpio, Lomeli R., Kakar, Sanjeev, Westendorf, Jennifer J., Kumar, Rajiv

“…•Repair of cortical bone defects is enhanced in sclerostin-deficient (Sost−/−) mice.•Osteoblasts and β-catenin are increased in cortical bone defects of…”
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Histone deacetylase 3 is required for maintenance of bone mass during aging by McGee-Lawrence, Meghan E, Bradley, Elizabeth W, Dudakovic, Amel, Carlson, Samuel W, Ryan, Zachary C, Kumar, Rajiv, Dadsetan, Mahrokh, Yaszemski, Michael J, Chen, Qingshan, An, Kai-Nan, Westendorf, Jennifer J

“…Abstract Histone deacetylase 3 (Hdac3) is a nuclear enzyme that removes acetyl groups from lysine residues in histones and other proteins to epigenetically…”
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The transcription regulator ATF4 is a mediator of skeletal muscle aging by Miller, Matthew J., Marcotte, George R., Basisty, Nathan, Wehrfritz, Cameron, Ryan, Zachary C., Strub, Matthew D., McKeen, Andrew T., Stern, Jennifer I., Nath, Karl A., Rasmussen, Blake B., Judge, Andrew R., Schilling, Birgit, Ebert, Scott M., Adams, Christopher M.

“…Aging slowly erodes skeletal muscle strength and mass, eventually leading to profound functional deficits and muscle atrophy. The molecular mechanisms of…”
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Alterations in vitamin D metabolite, parathyroid hormone and fibroblast growth factor-23 concentrations in sclerostin-deficient mice permit the maintenance of a high bone mass by Ryan, Zachary C., Craig, Theodore A., McGee-Lawrence, Meghan, Westendorf, Jennifer J., Kumar, Rajiv

“…[Display omitted] •Sost deficiency is associated with increased bone mass and osteoblast activity.•Increased serum 1,25(OH)2D enhances Ca and P balance in…”
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Multi-Omic Architecture of Obstructive Hypertrophic Cardiomyopathy by Garmany, Ramin, Bos, J. Martijn, Tester, David J., Giudicessi, John R., dos Remedios, Cristobal G., Dasari, Surendra, Nagaraj, Nagaswaroop K., Nair, Asha A., Johnson, Kenneth L., Ryan, Zachary C., Maleszewski, Joseph J., Ommen, Steve R., Dearani, Joseph A., Ackerman, Michael J.

“…Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular hypertrophy. Currently, hypertrophy pathways responsible for HCM have not…”
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Enhanced prostacyclin formation and Wnt signaling in sclerostin deficient osteocytes and bone by Ryan, Zachary C., Craig, Theodore A., Salisbury, Jeffrey L., Carpio, Lomeli R., McGee-Lawrence, Meghan, Westendorf, Jennifer J., Kumar, Rajiv

“…•Prostacyclin is increased in bone and osteocytes from sclerostin knockout mice.•Prostacyclin enhances differentiation and matrix mineralization of…”
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Hydrogen/Deuterium Exchange Reflects Binding of Human Centrin 2 to Ca(2+) and Xeroderma Pigmentosum Group C Peptide: An Example of EX1 Kinetics by Sperry, Justin B, Ryan, Zachary C, Kumar, Rajiv, Gross, Michael L

“…Xeroderma pigmentosum (XP) is a genetic disease affecting 1 in 10,000-100,000 and predisposes people to early-age skin cancer, a disease that is increasing…”
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Digging deeper into the immunopeptidome: characterization of post-translationally modified peptides presented by MHC I by Mangalaparthi, Kiran K., Madugundu, Anil K., Ryan, Zachary C., Garapati, Kishore, Peterson, Jane A., Dey, Gourav, Prakash, Amol, Pandey, Akhilesh

“…Peptides presented by MHC molecules on the cell surface, or the immunopeptidome, play an important role in the adaptive arm of the immune response. Antigen…”
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