Search Results - "Ryan, Tomás J."

Engram cells retain memory under retrograde amnesia by Ryan, Tomás J., Roy, Dheeraj S., Pignatelli, Michele, Arons, Autumn, Tonegawa, Susumu

“…Memory consolidation is the process by which a newly formed and unstable memory transforms into a stable long-term memory. It is unknown whether the process of…”
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Forgetting as a form of adaptive engram cell plasticity by Ryan, Tomás J., Frankland, Paul W.

“…One leading hypothesis suggests that memories are stored in ensembles of neurons (or ‘engram cells’) and that successful recall involves reactivation of these…”
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Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease by Roy, Dheeraj S., Arons, Autumn, Mitchell, Teryn I., Pignatelli, Michele, Ryan, Tomás J., Tonegawa, Susumu

“…Experiments in transgenic mouse models of early Alzheimer’s disease show that the amnesia seen at this stage of the disease is probably caused by a problem…”
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Creating a False Memory in the Hippocampus by Ramirez, Steve, Liu, Xu, Lin, Pei-Ann, Suh, Junghyup, Pignatelli, Michele, Redondo, Roger L., Ryan, Tomás J., Tonegawa, Susumu

“…Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram—bearing cells in the hippocampus. Dentate gyrus…”
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Memory engram storage and retrieval by Tonegawa, Susumu, Pignatelli, Michele, Roy, Dheeraj S, Ryan, Tomás J

“…Highlights • We review the history of research into putative memory storage mechanisms. • We highlight recent advances catalyzed by memory engram labeling…”
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Engram Cell Excitability State Determines the Efficacy of Memory Retrieval by Pignatelli, Michele, Ryan, Tomás J., Roy, Dheeraj S., Lovett, Chanel, Smith, Lillian M., Muralidhar, Shruti, Tonegawa, Susumu

“…Animals need to optimize the efficacy of memory retrieval to adapt to environmental circumstances for survival. The recent development of memory engram…”
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Understanding the physical basis of memory: Molecular mechanisms of the engram by Ortega-de San Luis, Clara, Ryan, Tomás J.

“…Memory, defined as the storage and use of learned information in the brain, is necessary to modulate behavior and critical for animals to adapt to their…”
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What is memory? The present state of the engram by Poo, Mu-Ming, Pignatelli, Michele, Ryan, Tomás J, Tonegawa, Susumu, Bonhoeffer, Tobias, Martin, Kelsey C, Rudenko, Andrii, Tsai, Li-Huei, Tsien, Richard W, Fishell, Gord, Mullins, Caitlin, Gonçalves, J Tiago, Shtrahman, Matthew, Johnston, Stephen T, Gage, Fred H, Dan, Yang, Long, John, Buzsáki, György, Stevens, Charles

“…The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist…”
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Framing the future of neuroscience in a time of great upheaval: Introducing a series of essays by the scholars of the FENS‐Kavli network by Donato, Flavio, Ryan, Tomás J.

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Engram cell connectivity as a mechanism for information encoding and memory function by Ortega-de San Luis, Clara, Pezzoli, Maurizio, Urrieta, Esteban, Ryan, Tomás J

“…Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and…”
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FENS‐Kavli Network of Excellence: Science needs strong European cohesion by O'Leary, Timothy, Hauser, Tobias U., Ryan, Tomás J., Rezaval, Carolina

“…Decades of scientific collaboration have brought innovation, prosperity and wide societal benefit to Europe. However, recent political events have impacted…”
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The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults by Martel, Marc-André, Ryan, Tomás J., Bell, Karen F.S., Fowler, Jill H., McMahon, Aoife, Al-Mubarak, Bashayer, Komiyama, Noboru H., Horsburgh, Karen, Kind, Peter C., Grant, Seth G.N., Wyllie, David J.A., Hardingham, Giles E.

“…It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR) excitotoxicity. We report that the toxicity of NMDAR-mediated Ca2+ influx is…”
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NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation by Frank, René A. W., Komiyama, Noboru H., Ryan, Tomás J., Zhu, Fei, O’Dell, Thomas J., Grant, Seth G. N.

“…How neuronal proteomes self-organize is poorly understood because of their inherent molecular and cellular complexity. Here, focusing on mammalian synapses we…”
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Adaptive expression of engrams by retroactive interference by Autore, Livia, O’Leary, James D., Ortega-de San Luis, Clara, Ryan, Tomás J.

“…Long-term memories are stored as configurations of neuronal ensembles, termed engrams. Although investigation of engram cell properties and functionality in…”
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Memory: It’s Not a Lie if You Believe It by Autore, Livia, Ryan, Tomás J.

“…Memories are crucial for making accurate predictions about our environment. New research suggests that, in the face of limited perceptual evidence, our brains…”
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The origin and evolution of synapses by Grant, Seth G. N, Ryan, Tomás J

“…Key Points The molecular composition of the synapse has recently been proved to be useful for studying the evolution of the brain. Synapse proteomics data…”
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Engram cell connectivity: an evolving substrate for information storage by Ryan, Tomás J, Ortega-de San Luis, Clara, Pezzoli, Maurizio, Sen, Siddhartha

“…•Engram cell labelling technology is transforming how we can investigate memory.•Different forms of engram cell specific plasticity can be observed and…”
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Amnesia after Repeated Head Impact Is Caused by Impaired Synaptic Plasticity in the Memory Engram by Chapman, Daniel P, Power, Sarah D, Vicini, Stefano, Ryan, Tomás J, Burns, Mark P

“…Subconcussive head impacts are associated with the development of acute and chronic cognitive deficits. We recently reported that high-frequency head impact…”
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On the research of time past: the hunt for the substrate of memory by Queenan, Bridget N., Ryan, Tomás J., Gazzaniga, Michael S., Gallistel, Charles R.

“…The search for memory is one of the oldest quests in written human history. For at least two millennia, we have tried to understand how we learn and remember…”
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The role of higher-order thalamus during learning and correct performance in goal-directed behavior by La Terra, Danilo, Bjerre, Ann-Sofie, Rosier, Marius, Masuda, Rei, Ryan, Tomás J, Palmer, Lucy M

“…The thalamus is a gateway to the cortex. Cortical encoding of complex behavior can therefore only be understood by considering the thalamic processing of…”
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