Search Results - "Ryan, Thomas A"

Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy by Ryan, Thomas A, Tumbarello, David A

“…Optineurin is a multifunctional adaptor protein intimately involved in various vesicular trafficking pathways. Through interactions with an array of proteins,…”
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Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor by Ponsford, Amy H., Ryan, Thomas A., Raimondi, Andrea, Cocucci, Emanuele, Wycislo, Susanne A., Fröhlich, Florian, Swan, Laura E., Stagi, Massimiliano

“…Disorders of lysosomal physiology have increasingly been found to underlie the pathology of a rapidly growing cast of neurodevelopmental disorders and sporadic…”
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Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia by Larkin, Caroline M, Hante, Nadhim Kamil, Breen, Eamon P, Tomaszewski, Krzysztof A, Eisele, Simon, Radomski, Marek W, Ryan, Thomas A, Santos-Martinez, Maria-Jose

“…The development of thrombocytopenia in sepsis is a poor prognostic indicator associated with a significantly increased mortality risk. Mechanisms underlying…”
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A central role for mitochondrial-derived vesicles in the innate immune response: implications for Parkinson's disease by Ryan, Thomas, Tumbarello, David

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Platelet microaggregation in sepsis examined by quartz crystal microbalance with dissipation technology by Larkin, Caroline M, Breen, Eamon P, Tomaszewski, Krzysztof A, Eisele, Simon, Radomski, Marek W, Ryan, Thomas A, Santos-Martinez, Maria-Jose

“…Antiplatelet therapies remain an area of potential interest for the treatment of sepsis; however, studies of platelet aggregation in sepsis have yielded…”
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A density functional theory and spectroscopic study of intramolecular quenching of metal-to-ligand charge-transfer excited states in some mono-bipyridine ruthenium(II) complexes by Mazumder, Shivnath, Thomas, Ryan A, Lord, Richard L, Schlegel, H. Bernhard, Endicott, John F

“…The complexes [Ru(NCCH 3 ) 4 bpy] 2+ and [Ru([14]aneS 4 )bpy] 2+ ([14]aneS 4 = 1,4,8,11-tetrathiacyclotetradecane, bpy = 2,2′-bipyridine) have similar…”
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Stress Resilience and the Dynamic Regulation of Glucocorticoids by Vitousek, Maren N, Taff, Conor C, Ryan, Thomas A, Zimmer, Cedric

“…Abstract Vertebrates respond to a diversity of stressors by rapidly elevating glucocorticoid (GC) levels. The changes in physiology and behavior triggered by…”
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Tollip coordinates Parkin‐dependent trafficking of mitochondrial‐derived vesicles by Ryan, Thomas A, Phillips, Elliott O, Collier, Charlotte L, JB Robinson, Alice, Routledge, Daniel, Wood, Rebecca E, Assar, Emelia A, Tumbarello, David A

“…Multiple mitochondrial quality control pathways exist to maintain the health of mitochondria and ensure cell homeostasis. Here, we investigate the role of the…”
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Cold temperatures induce priming of the glucose stress response in tree swallows by Ryan, Thomas A., Taff, Conor C., Zimmer, Cedric, Vitousek, Maren N.

“…Capricious environments often present wild animals with challenges that coincide or occur in sequence. Conceptual models of the stress response predict that…”
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On again, off again: Acute stress response and negative feedback together predict resilience to experimental challenges by Zimmer, Cedric, Taff, Conor C., Ardia, Daniel R., Ryan, Thomas A., Winkler, David W., Vitousek, Maren N., Angelier, Frédéric

“…Individuals often vary markedly in their ability to cope with stressors, but the drivers of this variation remain poorly understood. Many studies have tested…”
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Experimentally elevated corticosterone does not affect bacteria killing ability of breeding female tree swallows (Tachycineta bicolor) by Chang van Oordt, David A., Taff, Conor C., Pipkin, Monique A., Ryan, Thomas A., Vitousek, Maren N.

“…The immune system can be modulated when organisms are exposed to acute or chronic stressors. Glucocorticoids (GCs), the primary hormonal mediators of the…”
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Developmental stage‐dependent effects of perceived predation risk on nestling tree swallows (Tachycineta bicolor) by McNew, Sabrina M., Taff, Conor C., Zimmer, Cedric, Uehling, Jennifer J., Ryan, Thomas A., Chang van Oordt, David, Houtz, Jennifer L., Injaian, Allison S., Vitousek, Maren N.

“…The risk of predation directly affects the physiology, behavior, and fitness of wild birds. Strong social connections with conspecifics could help individuals…”
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Timing of Breeding Reveals a Trade-Off between Immune Investment and Life History in Tree Swallows by Chang van Oordt, David A, Taff, Conor C, Ryan, Thomas A, Vitousek, Maren N

“…The allocation of limited resources among life history traits creates trade-offs that constrain the range of possible phenotypes of organisms. In animals, the…”
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Individual variation in natural or manipulated corticosterone does not covary with circulating glucose in a wild bird by Taff, Conor C, Zimmer, Cedric, Ryan, Thomas A, van Oordt, David Chang, Aborn, David A, Ardia, Daniel R, Johnson, L Scott, Rose, Alexandra P, Vitousek, Maren N

“…Animals respond to sudden challenges with a coordinated set of physiological and behavioral responses that enhance the ability to cope with stressors. While…”
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A MAPK/c-Jun-mediated switch regulates the initial adaptive and cell death responses to mitochondrial damage in a neuronal cell model by Ryan, Thomas A., Roper, Katherine M., Bond, Jacquelyn, Bell, Sandra M., Sweeney, Sean T., Morrison, Ewan E.

“…•Undifferentiated/differentiated SH-SY5Y cells provide distinct model systems.•Parkin specifically sensitises to mitochondrial uncoupling.•Kinases…”
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Energy Dependence of the Ruthenium(II)-Bipyridine Metal-to-Ligand-Charge-Transfer Excited State Radiative Lifetimes: Effects of ππ(bipyridine) Mixing by Thomas, Ryan A, Tsai, Chia Nung, Mazumder, Shivnath, Lu, I Chen, Lord, Richard L, Schlegel, H. Bernhard, Chen, Yuan Jang, Endicott, John F

“…The variations in band shape with excited state energy found for the triplet metal to ligand charge transfer (3MLCT) emission spectra of ruthenium-bipyridine…”
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Predictors of outcome in cardiac surgical patients with prolonged intensive care stay by Ryan, T A, Rady, M Y, Bashour, C A, Leventhal, M, Lytle, B, Starr, N J

“…To determine the predictors of outcome in cardiac surgical patients with prolonged ICU stay. Inception cohort with retrospective chart review. Adult…”
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Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma by Abdelhamed, Zakia A, Ryan, Thomas A, Fuller, Martin, Coulson-Gilmer, Camilla, Abdelmottaleb, Dina I, Wang, Tian-Li, Kaun, Jen-Chun, Wang, Peiyi, Hutson, Richard, Wilkinson, Nafisa, Bell, Sandra M, Johnson, Colin A

“…The aim of this study was to investigate the distribution of primary cilia on secretory cells in normal fallopian tube (FT) and serous tubal intraepithelial…”
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Social signal manipulation and environmental challenges have independent effects on physiology, internal microbiome, and reproductive performance in tree swallows (Tachycineta bicolor) by Taff, Conor C., McNew, Sabrina M., Zimmer, Cedric, Uehling, Jennifer J., Houtz, Jennifer L., Ryan, Thomas A., Chang van Oordt, David, Injaian, Allison S., Vitousek, Maren N.

“…The social environment that individuals experience appears to be a particularly salient mediator of stress resilience, as the nature and valence of social…”
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PFAS Experts Symposium 2: PFAS Remediation research – Evolution from past to present, current efforts, and potential futures by Newell, Charles J., DiGuiseppi, William H., Cassidy, Daniel P., Divine, Craig E., Fenstermacher, James M., Hagelin, Nathan W., Thomas, Ryan A., Tomiczek, Paul, Warner, Scott D., Xiong, Zhong John, Hatzinger, Paul B.

“…Due to the diverse chemistries of per‐ and polyfluoroalkyl substances (PFAS) and their apparent recalcitrance to natural biological and abiotic transformation…”
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