Search Results - "Ryan, T A"

Single-vesicle imaging reveals that synaptic vesicle exocytosis and endocytosis are coupled by a single stochastic mode by Balaji, J, Ryan, T.A

“…The nature of synaptic vesicle recycling at nerve terminals has been a subject of considerable debate for >35 years. Here, we report the use of an optical…”
Get full text

Stress and neurodevelopmental processes in the emergence of psychosis by Holtzman, C.W, Trotman, H.D, Goulding, S.M, Ryan, A.T, MacDonald, A.N, Shapiro, D.I, Brasfield, J.L, Walker, E.F

“…Highlights ► We review the evidence supporting associations between psychosocial stress and psychosis. ► We discuss the possible role of biological stress…”
Get full text

The use of small angle neutron scattering with contrast matching and variable adsorbate partial pressures in the study of porosity in activated carbons by Mileeva, Z., Ross, D.K., Wilkinson, D., King, S.M., Ryan, T.A., Sharrock, H.

“…The porosity of a typical activated carbon is investigated with small angle neutron scattering (SANS), using the contrast matching technique, by changing the…”
Get full text

Real-time measurements of vesicle-SNARE recycling in synapses of the central nervous system by Ryan, Timothy A, Sankaranarayanan, Sethuraman

“…Following the fusion of synaptic vesicles with the presynaptic plasma membrane of nerve terminals by the process of exocytosis, synaptic-vesicle components are…”
Get full text

Modification of Proteins by Metabolites in Immunity by Diskin, C., Ryan, T.A.J., O’Neill, L.A.J.

“…Immunometabolism has emerged as a key focus for immunologists, with metabolic change in immune cells becoming as important a determinant for specific immune…”
Get full text

Calcium accelerates endocytosis of vSNAREs at hippocampal synapses by Ryan, Timothy A, Sankaranarayanan, Sethuraman

“…A pH-sensitive form of green-fluorescent protein (GFP) fused to the lumenal domain of VAMP (synapto-pHluorin) provides a sensitive optical probe to track the…”
Get full text

Presynaptic imaging techniques by Ryan, Timothy A

“…Understanding the detailed molecular events that support chemical synaptic transmission requires high-resolution methods that provide quantitative information…”
Get full text

The effects of soy milk and isoflavone supplements on cognitive performance in healthy, postmenopausal women by Fournier, L R, Ryan Borchers, T A, Robison, L M, Wiediger, M, Park, J S, Chew, B P, McGuire, M K, Sclar, D A, Skaer, T L, Beerman, K A

“…The decline in estrogen concentrations in women after menopause can contribute to health related changes including impairments in cognition, especially memory…”
Get more information

Short-Term Effects of Military Fog Oil on the Fountain Darter (Etheostoma fonticola) by Ryan, T. A., Kohl, A. N., Soucek, D. J., Smith, T. S., Brandt, T. M., Bonner, T. H., Cropek, D. M.

“…Toxicity tests evaluated chronic and sublethal effects of fog oil (FO) on a freshwater endangered fish. FO is released during military training as an obscurant…”
Get full text

An association between electronic nicotine delivery systems use and a history of stroke using the 2016 behavioral risk factor surveillance system by Bricknell, Ryan A.T., Ducaud, Christobal, Figueroa, Alejandra, Schwarzman, Logan S., Rodriguez, Pura, Castro, Grettel, Zevallos, Juan Carlos, Barengo, Noël C.

“…Electronic nicotine delivery systems (ENDS) are growing in use and many of the health implications with these devices remain unknown. This study aims to…”
Get full text

A heart team approach to assessing frailty in the cardiac catheterization laboratory by Bricknell, Ryan A.T., Schwarzman, Logan S., Taylor, Jeffrey, Soltes, Tiago, Vidovich, Mladen I.

“…Frailty is a well-documented risk factor for increased morbidity and mortality among patients undergoing percutaneous coronary intervention (PCI). There…”
Get full text

The Timing of Synaptic Vesicle Endocytosis by Ryan, Timothy A., Smith, Stephen J, Reuter, Harald

“…Alternative models to describe the endocytosis phase of synaptic vesicle recycling are associated with time scales of vesicle recovery ranging from…”
Get full text

The kinetics of synaptic vesicle recycling measured at single presynaptic boutons by Ryan, T A, Reuter, H, Wendland, B, Schweizer, F E, Tsien, R W, Smith, S J

“…We used the fluorescent membrane probe FM 1-43 to label recycling synaptic vesicles within the presynaptic boutons of dissociated hippocampal neurons in…”
Get more information

Calcium Control of Endocytic Capacity at a CNS Synapse by Balaji, J, Armbruster, Moritz, Ryan, Timothy A

“…The ability to recycle synaptic vesicles is a crucial property of nerve terminals that allows maintenance of synaptic transmission. Using high-sensitivity…”
Get full text

Optical detection of a quantal presynaptic membrane turnover by Ryan, Timothy A, Reuter, Harald, Smith, Stephen J

“…Exploration of the mechanisms and plasticity of synaptic transmission has been hindered by the lack of a method to measure single vesicle turnover directly in…”
Get full text

Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria by Francis, Carol L, Ryan, Timothy A, Jones, Bradley D, Smith, Stephen J, Falkow, Stanley

“…Ruffles are specialized plasma membrane ultrastructures of mammalian cells though to be integral to growth, development and locomotion. Induced by growth…”
Get full text

Synaptic Vesicle Recycling in Synapsin I Knock-out Mice by Ryan, Timothy A., Li, Lian, Chin, Lih-Shen, Greengard, Paul, Smith, Stephen J.

“…The synapsins are a family of four neuron-specific phosphoproteins that have been implicated in the regulation of neurotransmitter release. Nevertheless,…”
Get full text

Spatial and Temporal Dissection of Immediate and Early Events Following Cadherin-Mediated Epithelial Cell Adhesion by McNeill, Helen, Ryan, Timothy A., Smith, Stephen J., Nelson, W. James

“…Cell-cell adhesion is at the top of a molecular cascade of protein interactions that leads to the remodeling of epithelial cell structure and function. The…”
Get full text

Synaptic Vesicle Mobilization Is Regulated by Distinct Synapsin I Phosphorylation Pathways at Different Frequencies by Chi, Ping, Greengard, Paul, Ryan, Timothy A

“…During action potential firing, the rate of synapsin dissociation from synaptic vesicles and dispersion into axons controls the rate of vesicle availability…”
Get full text

Existence of Nitric Oxide Synthase in Rat Hippocampal Pyramidal Cells by Wendland, Beverly, Schweizer, Felix E., Ryan, Timothy A., Nakane, Masaki, Murad, Ferid, Scheller, Richard H., Tsien, Richard W.

“…It has been proposed that nitric oxide (NO) serves as a key retrograde messenger during long-term potentiation at hippocampal synapses, linking induction of…”
Get full text