Search Results - "Ryan, Scott D"

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription by Ryan, Scott D., Dolatabadi, Nima, Chan, Shing Fai, Zhang, Xiaofei, Akhtar, Mohd Waseem, Parker, James, Soldner, Frank, Sunico, Carmen R., Nagar, Saumya, Talantova, Maria, Lee, Brian, Lopez, Kevin, Nutter, Anthony, Shan, Bing, Molokanova, Elena, Zhang, Yaoyang, Han, Xuemei, Nakamura, Tomohiro, Masliah, Eliezer, Yates, John R., Nakanishi, Nobuki, Andreyev, Aleksander Y., Okamoto, Shu-ichi, Jaenisch, Rudolf, Ambasudhan, Rajesh, Lipton, Stuart A.

“…Parkinson’s disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). An association has been…”
Get full text

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein by Ryan, Tammy, Bamm, Vladimir V., Stykel, Morgan G., Coackley, Carla L., Humphries, Kayla M., Jamieson-Williams, Rhiannon, Ambasudhan, Rajesh, Mosser, Dick D., Lipton, Stuart A., Harauz, George, Ryan, Scott D.

“…Neuronal loss in Parkinson’s disease (PD) is associated with aberrant mitochondrial function and impaired proteostasis. Identifying the mechanisms that link…”
Get full text

Nitrosative stress in Parkinson’s disease by Stykel, Morgan G., Ryan, Scott D.

“…Parkinson’s Disease (PD) is a neurodegenerative disorder characterized, in part, by the loss of dopaminergic neurons within the nigral-striatal pathway…”
Get full text

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism by Tu, Shichun, Akhtar, Mohd Waseem, Escorihuela, Rosa Maria, Amador-Arjona, Alejandro, Swarup, Vivek, Parker, James, Zaremba, Jeffrey D., Holland, Timothy, Bansal, Neha, Holohan, Daniel R., Lopez, Kevin, Ryan, Scott D., Chan, Shing Fai, Yan, Li, Zhang, Xiaofei, Huang, Xiayu, Sultan, Abdullah, McKercher, Scott R., Ambasudhan, Rajesh, Xu, Huaxi, Wang, Yuqiang, Geschwind, Daniel H., Roberts, Amanda J., Terskikh, Alexey V., Rissman, Robert A., Masliah, Eliezer, Lipton, Stuart A., Nakanishi, Nobuki

“…Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD), and human MEF2C haploinsufficiency results in ASD, intellectual…”
Get full text

Microtubule stability, Golgi organization, and transport flux require dystonin-a2-MAP1B interaction by Ryan, Scott D, Bhanot, Kunal, Ferrier, Andrew, De Repentigny, Yves, Chu, Alphonse, Blais, Alexandre, Kothary, Rashmi

“…Loss of function of dystonin cytoskeletal linker proteins causes neurodegeneration in dystonia musculorum (dt) mutant mice. Although much investigation has…”
Get full text

Author Correction: Nitrosative stress in Parkinson’s disease by Stykel, Morgan G., Ryan, Scott D.

Get full text

Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy by Parmasad, Jean-Louis A., Ricke, Konrad M., Nguyen, Benjamin, Stykel, Morgan G., Buchner-Duby, Brodie, Bruce, Amanda, Geertsma, Haley M., Lian, Eric, Lengacher, Nathalie A., Callaghan, Steve M., Joselin, Alvin, Tomlinson, Julianna J., Schlossmacher, Michael G., Stanford, William L., Ma, Jiyan, Brundin, Patrik, Ryan, Scott D., Rousseaux, Maxime W. C.

“…Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal…”
Get full text

Motor unit abnormalities in Dystonia musculorum mice by De Repentigny, Yves, Ferrier, Andrew, Ryan, Scott D, Sato, Tadasu, Kothary, Rashmi

“…Dystonia musculorum (dt) is a mouse inherited sensory neuropathy caused by mutations in the dystonin gene. While the primary pathology lies in the sensory…”
Get full text

High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons by Piña-Crespo, Juan C, Talantova, Maria, Cho, Eun-Gyung, Soussou, Walid, Dolatabadi, Nima, Ryan, Scott D, Ambasudhan, Rajesh, McKercher, Scott, Deisseroth, Karl, Lipton, Stuart A

“…After transplantation, individual stem cell-derived neurons can functionally integrate into the host CNS; however, evidence that neurons derived from…”
Get full text

Neuronal dystonin isoform 2 is a mediator of endoplasmic reticulum structure and function by Ryan, Scott D, Ferrier, Andrew, Sato, Tadasu, O'Meara, Ryan W, De Repentigny, Yves, Jiang, Susan X, Hou, Sheng T, Kothary, Rashmi

“…Dystonin/Bpag1 is a cytoskeletal linker protein whose loss of function in dystonia musculorum (dt) mice results in hereditary sensory neuropathy. Although loss…”
Get full text

Amyloid-β₄₂ signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism by Ryan, Scott D, Whitehead, Shawn N, Swayne, Leigh Anne, Moffat, Tia C, Hou, Weimin, Ethier, Martin, Bourgeois, André J.G, Rashidian, Juliet, Blanchard, Alexandre P, Fraser, Paul E, Park, David S, Figeys, Daniel, Bennett, Steffany A.L

“…Perturbation of lipid second messenger networks is associated with the impairment of synaptic function in Alzheimer disease. Underlying molecular mechanisms…”
Get full text

Network analysis of S-nitrosylated synaptic proteins demonstrates unique roles in health and disease by Stykel, Morgan G., Ryan, Scott D.

“…Nitric oxide can covalently modify cysteine thiols on target proteins to alter that protein's function in a process called S-nitrosylation (SNO)…”
Get full text

Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative beta-catenin by Kennedy, Karen A M, Porter, Tammy, Mehta, Virja, Ryan, Scott D, Price, Feodor, Peshdary, Vian, Karamboulas, Christina, Savage, Josée, Drysdale, Thomas A, Li, Shun-Cheng, Bennett, Steffany A L, Skerjanc, Ilona S

“…Understanding stem cell differentiation is essential for the future design of cell therapies. While retinoic acid (RA) is the most potent small molecule…”
Get full text

Nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of Parkinson's disease by Stykel, Morgan G., Humphries, Kayla, Kirby, Mathew P., Czaniecki, Chris, Wang, Tinya, Ryan, Tammy, Bamm, Vladimir, Ryan, Scott D.

“…ABSTRACT Neuronal loss in Parkinson's disease (PD) is associated with aberrant mitochondrial function in dopaminergic (DA) neurons of the substantia nigra pars…”
Get full text

Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons by Ryan, Scott D, Harris, Cory S, Carswell, Casey L, Baenziger, John E, Bennett, Steffany A.L

“…The platelet-activating factor (PAF) family of glycerophospholipids accumulates in damaged brain tissue following injury. Little is known about the role of…”
Get full text

State-level policies and reunification: A multi-level survival analysis by LaBrenz, Catherine A., Jenkins, Lacey, Huang, Hui, Ryan, Scott D., Panisch, Lisa S., Kim, Yeonwoo, Baiden, Philip

“…A growing body of research has focused on the relationships of policies and other macro factors and child welfare outcomes. However, to date, few studies have…”
Get full text

Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines by Hallam, Ryan D, Buchner-Duby, Brodie, Stykel, Morgan G, Coackley, Carla L, Ryan, Scott D

“…Cortical synucleinopathies, including dementia with Lewy bodies and Parkinson's disease dementia, collectively known as Lewy body dementia, are characterized…”
Get full text

Docosahexanoic acid signals through the Nrf2-Nqo1 pathway to maintain redox balance and promote neurite outgrowth by Drolet, Jennifer, Buchner-Duby, Brodie, Stykel, Morgan G, Coackley, Carla, Kang, Jing X, Ma, David W L, Ryan, Scott D

“…Evidence suggests that n-3 polyunsaturated fatty acids may act as activators of the Nrf2 antioxidant pathway. The antioxidant response, in turn, promotes…”
Get full text

α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology by Stykel, Morgan G., Humphries, Kayla M., Kamski-Hennekam, Evelyn, Buchner-Duby, Brodie, Porte-Trachsel, Natalie, Ryan, Tammy, Coackley, Carla L., Bamm, Vladimir V., Harauz, George, Ryan, Scott D.

“…Neuronal loss in Parkinson’s disease (PD) is associated with impaired proteostasis and accumulation of α-syn microaggregates in dopaminergic neurons. These…”
Get full text

Untethering the Nuclear Envelope and Cytoskeleton: Biologically Distinct Dystonias Arising from a Common Cellular Dysfunction by Atai, Nadia A., Ryan, Scott D., Kothary, Rashmi, Breakefield, Xandra O., Nery, Flávia C.

“…Most cases of early onset DYT1 dystonia in humans are caused by a GAG deletion in the TOR1A gene leading to loss of a glutamic acid (ΔE) in the torsinA…”
Get full text