Search Results - "Ryan, Renae M."

Mechanisms of glutamate transport by Vandenberg, Robert J, Ryan, Renae M

“…L-Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system and plays important roles in a wide variety of brain…”
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Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5 by Scopelliti, Amanda J, Font, Josep, Vandenberg, Robert J, Boudker, Olga, Ryan, Renae M

“…Cancer cells undergo a shift in metabolism where they become reliant on nutrients such as the amino-acid glutamine. Glutamine enters the cell via the…”
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Targeting glutamine transport to suppress melanoma cell growth by Wang, Qian, Beaumont, Kimberley A., Otte, Nicholas J., Font, Josep, Bailey, Charles G., Geldermalsen, Michelle, Sharp, Danae M., Tiffen, Jessamy C., Ryan, Renae M., Jormakka, Mika, Haass, Nikolas K., Rasko, John E.J., Holst, Jeff

“…Amino acids, especially leucine and glutamine, are important for tumor cell growth, survival and metabolism. A range of different transporters deliver each…”
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Regulation of Glutamate, GABA and Dopamine Transporter Uptake, Surface Mobility and Expression by Ryan, Renae M, Ingram, Susan L, Scimemi, Annalisa

“…Neurotransmitter transporters limit spillover between synapses and maintain the extracellular neurotransmitter concentration at low yet physiologically…”
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Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter by Ryan, Renae M, Shimamoto, Keiko, Yernool, Dinesh, Gouaux, Eric, Boudker, Olga

“…Secondary transporters are integral membrane proteins that catalyse the movement of substrate molecules across the lipid bilayer by coupling substrate…”
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Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function by Wu, Qianyi, Akhter, Azman, Pant, Shashank, Cho, Eunjoo, Zhu, Jin Xin, Garner, Alastair, Ohyama, Tomoko, Tajkhorshid, Emad, van Meyel, Donald J, Ryan, Renae M

“…Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS). Excitatory amino acid transporters (EAATs) regulate…”
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Structural basis of promiscuous substrate transport by Organic Cation Transporter 1 by Zeng, Yi C., Sobti, Meghna, Quinn, Ada, Smith, Nicola J., Brown, Simon H. J., Vandenberg, Jamie I., Ryan, Renae M., O’Mara, Megan L., Stewart, Alastair G.

“…Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations…”
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Glycine transport inhibitors for the treatment of pain by Vandenberg, Robert J, Ryan, Renae M, Carland, Jane E, Imlach, Wendy L, Christie, Macdonald J

“…Highlights • Many patients suffering from chronic pain do not find relief from current analgesics. • Glycine neurotransmission in the spinal cord is altered in…”
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The Domain Interface of the Human Glutamate Transporter EAAT1 Mediates Chloride Permeation by Cater, Rosemary J., Vandenberg, Robert J., Ryan, Renae M.

“…The concentration of glutamate within the glutamatergic synapse is tightly regulated by the excitatory amino-acid transporters (EAATs). In addition to their…”
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Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma by Zhou, Qingqing, Phoa, Athena F, Abbassi, Ramzi H, Hoque, Monira, Reekie, Tristan A, Font, Josep S, Ryan, Renae M, Stringer, Brett W, Day, Bryan W, Johns, Terrance G, Munoz, Lenka, Kassiou, Michael

“…The DYRK family contains kinases that are up-regulated in malignancy and control several cancer hallmarks. To assess the anticancer potential of inhibitors…”
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Position of the third Na+ site in the aspartate transporter GltPh and the human glutamate transporter, EAAT1 by Bastug, Turgut, Heinzelmann, Germano, Kuyucak, Serdar, Salim, Marietta, Vandenberg, Robert J, Ryan, Renae M

“…Glutamate transport via the human excitatory amino acid transporters is coupled to the co-transport of three Na(+) ions, one H(+) and the counter-transport of…”
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Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria by Bailey, Charles G, Ryan, Renae M, Thoeng, Annora D, Ng, Cynthia, King, Kara, Vanslambrouck, Jessica M, Auray-Blais, Christiane, Vandenberg, Robert J, Bröer, Stefan, Rasko, John E J

“…Solute carrier family 1, member 1 (SLC1A1; also known as EAAT3 and EAAC1) is the major epithelial transporter of glutamate and aspartate in the kidneys and…”
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Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics by Mostyn, Shannon N, Wilson, Katie A, Schumann-Gillett, Alexandra, Frangos, Zachary J, Shimmon, Susan, Rawling, Tristan, Ryan, Renae M, O'Mara, Megan L, Vandenberg, Robert J

“…The treatment of chronic pain is poorly managed by current analgesics, and there is a need for new classes of drugs. We recently developed a series of…”
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Functional Characterization of a Na+-dependent Aspartate Transporter from Pyrococcus horikoshii by Ryan, Renae M., Compton, Emma L.R., Mindell, Joseph A.

“…Excitatory amino acid transporters (EAATs) are crucial in maintaining extracellular levels of glutamate, the most abundant excitatory neurotransmitter, below…”
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The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter by Cater, Rosemary J., Ryan, Renae M., Vandenberg, Robert J.

“…Transporters and ion channels are conventionally categorised into distinct classes of membrane proteins. However, some membrane proteins have a split…”
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Identification of a 3rd Na+ Binding Site of the Glycine Transporter, GlyT2 by Subramanian, Nandhitha, Scopelitti, Amanda J, Carland, Jane E, Ryan, Renae M, O'Mara, Megan L, Vandenberg, Robert J

“…The Na+/Cl- dependent glycine transporters GlyT1 and GlyT2 regulate synaptic glycine concentrations. Glycine transport by GlyT2 is coupled to the co-transport…”
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Lipid inhibitors of high affinity glycine transporters: Identification of a novel class of analgesics by Carland, Jane E., Handford, Cheryl A., Ryan, Renae M., Vandenberg, Robert J.

“…•Glycine in the CNS is regulated by the glycine transporters, GlyT1 and GlyT2.•Lipid inhibitors of GlyT2 show promise as analgesics.•N-arachidonyl-glycine and…”
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Correction: Identification of a 3rd Na+ Binding Site of the Glycine Transporter, GlyT2 by Subramanian, Nandhitha, Scopelliti, Amanda J, Carland, Jane E, Ryan, Renae M, O'Mara, Megan L, Vandenberg, Robert J

“…[This corrects the article DOI: 10.1371/journal.pone.0157583.]…”
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Characterizing unexpected interactions of a glutamine transporter inhibitor with members of the SLC1A transporter family by Freidman, Natasha J., Briot, Chelsea, Ryan, Renae M.

“…The solute carrier 1A family comprises a group of membrane proteins that act as dual-function amino acid transporters and chloride (Cl−) channels and includes…”
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The Chloride Permeation Pathway of a Glutamate Transporter and Its Proximity to the Glutamate Translocation Pathway by Ryan, Renae M, Mitrovic, Ann D, Vandenberg, Robert J

“…Excitatory amino acid transporters (EAATs) regulate glutamate concentrations in the brain to maintain normal excitatory synaptic transmission. A widely…”
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