Search Results - "Ryan, Natalie K."

Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus by Hadjur, Suzana, Williams, Luke M., Ryan, Natalie K., Cobb, Bradley S., Sexton, Tom, Fraser, Peter, Fisher, Amanda G., Merkenschlager, Matthias

“…Cohesin branches out As well as its role in sister chromatid cohesion, the cohesin protein complex is thought be involved in the control of gene expression…”
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ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer by Centenera, Margaret M, Scott, Julia S, Machiels, Jelle, Nassar, Zeyad D, Miller, Deanna C, Zinonos, Irene, Dehairs, Jonas, Burvenich, Ingrid J G, Zadra, Giorgia, Chetta, Paolo M, Bango, Clyde, Evergren, Emma, Ryan, Natalie K, Gillis, Joanna L, Mah, Chui Yan, Tieu, Terence, Hanson, Adrienne R, Carelli, Ryan, Bloch, Katarzyna, Panagopoulos, Vasilios, Waelkens, Etienne, Derua, Rita, Williams, Elizabeth D, Evdokiou, Andreas, Cifuentes-Rius, Anna, Voelcker, Nicolas H, Mills, Ian G, Tilley, Wayne D, Scott, Andrew M, Loda, Massimo, Selth, Luke A, Swinnen, Johannes V, Butler, Lisa M

“…The androgen receptor (AR) is the key oncogenic driver of prostate cancer, and despite implementation of novel AR targeting therapies, outcomes for metastatic…”
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A patient‐derived explant (PDE) model of hormone‐dependent cancer by Centenera, Margaret M., Hickey, Theresa E., Jindal, Shalini, Ryan, Natalie K., Ravindranathan, Preethi, Mohammed, Hisham, Robinson, Jessica L., Schiewer, Matthew J., Ma, Shihong, Kapur, Payal, Sutherland, Peter D., Hoffmann, Clive E., Roehrborn, Claus G., Gomella, Leonard G., Carroll, Jason S., Birrell, Stephen N., Knudsen, Karen E., Raj, Ganesh V., Butler, Lisa M., Tilley, Wayne D.

“…Breast and prostate cancer research to date has largely been predicated on the use of cell lines in vitro or in vivo. These limitations have led to the…”
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FixNCut: single-cell genomics through reversible tissue fixation and dissociation by Jiménez-Gracia, Laura, Marchese, Domenica, Nieto, Juan C, Caratù, Ginevra, Melón-Ardanaz, Elisa, Gudiño, Victoria, Roth, Sara, Wise, Kellie, Ryan, Natalie K, Jensen, Kirk B, Hernando-Momblona, Xavier, Bernardes, Joana P, Tran, Florian, Sievers, Laura Katharina, Schreiber, Stefan, van den Berge, Maarten, Kole, Tessa, van der Velde, Petra L, Nawijn, Martijn C, Rosenstiel, Philip, Batlle, Eduard, Butler, Lisa M, Parish, Ian A, Plummer, Jasmine, Gut, Ivo, Salas, Azucena, Heyn, Holger, Martelotto, Luciano G

“…The use of single-cell technologies for clinical applications requires disconnecting sampling from downstream processing steps. Early sample preservation can…”
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ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency by Pereira, Carlos F., Piccolo, Francesco M., Tsubouchi, Tomomi, Sauer, Stephan, Ryan, Natalie K., Bruno, Ludovica, Landeira, David, Santos, Joana, Banito, Ana, Gil, Jesus, Koseki, Haruhiko, Merkenschlager, Matthias, Fisher, Amanda G.

“…Embryonic stem cells (ESCs) are pluripotent, self-renewing, and have the ability to reprogram differentiated cell types to pluripotency upon cellular fusion…”
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Expression of androgen receptor splice variants in clinical breast cancers by Hickey, Theresa E, Irvine, Connie M, Dvinge, Heidi, Tarulli, Gerard A, Hanson, Adrienne R, Ryan, Natalie K, Pickering, Marie A, Birrell, Stephen N, Hu, Dong Gui, Mackenzie, Peter I, Russell, Roslin, Caldas, Carlos, Raj, Ganesh V, Dehm, Scott M, Plymate, Stephen R, Bradley, Robert K, Tilley, Wayne D, Selth, Luke A

“…The importance of androgen receptor (AR) signaling is increasingly being recognized in breast cancer, which has elicited clinical trials aimed at assessing the…”
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A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth by Gillis, Joanna L, Hinneh, Josephine A, Ryan, Natalie K, Irani, Swati, Moldovan, Max, Quek, Lake-Ee, Shrestha, Raj K, Hanson, Adrienne R, Xie, Jianling, Hoy, Andrew J, Holst, Jeff, Centenera, Margaret M, Mills, Ian G, Lynn, David J, Selth, Luke A, Butler, Lisa M

“…Alterations to the androgen receptor (AR) signalling axis and cellular metabolism are hallmarks of prostate cancer. This study provides insight into both…”
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Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development by BIANCO-MIOTTO, Tina, CHIAM, Karen, HORVATH, Lisa G, KENCH, James G, STRICKER, Phillip D, MARSHALL, Villis R, SUTHERLAND, Robert L, HENSHALL, Susan M, GERALD, William L, SCHER, Howard I, RISBRIDGER, Gail P, CLEMENTS, Judith A, BUCHANAN, Grant, BUTLER, Lisa M, TILLEY, Wayne D, HORSFALL, David J, RICCIARDELLI, Carmela, JINDAL, Shalini, DAY, Tanya K, THOMAS, Mervyn, PICKERING, Marie A, O'LOUGHLIN, Melissa A, RYAN, Natalie K, RAYMOND, Wendy A

“…Epigenetic alterations are common in prostate cancer, yet how these modifications contribute to carcinogenesis is poorly understood. We investigated whether…”
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Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2 by Pereira, Carlos F, Terranova, Rémi, Ryan, Natalie K, Santos, Joana, Morris, Kelly J, Cui, Wei, Merkenschlager, Matthias, Fisher, Amanda G

“…Differentiated cells can be reprogrammed through the formation of heterokaryons and hybrid cells when fused with embryonic stem (ES) cells. Here, we provide…”
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Leptin and Leptin Receptor Expression in the Rat Ovary by Ryan, Natalie K, Van der Hoek, Kylie H, Robertson, Sarah A, Norman, Robert J

“…Leptin is an important satiety hormone and reproductive regulator and is found, along with its receptors, throughout the ovary. To date, the changes in ovarian…”
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Expression of Leptin and Its Receptor in the Murine Ovary: Possible Role in the Regulation of Oocyte Maturation by RYAN, Natalie K, WOODHOUSE, Carole M, VAN DER HOEK, Kylie H, GILCHRIST, Robert B, ARMSTRONG, David T, NORMAN, Robert J

“…Leptin is a product of the ob gene that is produced primarily by adipose tissue. Leptin and its receptors are found within the ovary, but it is unclear what…”
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Targeting hyaluronan-mediated motility receptor (HMMR) enhances response to androgen receptor signalling inhibitors in prostate cancer by Hinneh, Josephine A., Gillis, Joanna L., Mah, Chui Yan, Irani, Swati, Shrestha, Raj K., Ryan, Natalie K., Atsushi, Enomoto, Nassar, Zeyad D., Lynn, David J., Selth, Luke A., Kato, Masashi, Centenera, Margaret M., Butler, Lisa M.

“…Background Resistance to androgen receptor signalling inhibitors (ARSIs) represents a major clinical challenge in prostate cancer. We previously demonstrated…”
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AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer by Sardar, Sumaira, McNair, Christopher M., Ravindranath, Lakshmi, Chand, Saswati N., Yuan, Wei, Bogdan, Denisa, Welti, Jon, Sharp, Adam, Ryan, Natalie K., Knudsen, Liam A., Schiewer, Matthew J., DeArment, Elise G., Janas, Thomas, Su, Xiaofeng A., Butler, Lisa M., de Bono, Johann S., Frese, Kris, Brooks, Nigel, Pegg, Neil, Knudsen, Karen E., Shafi, Ayesha A.

“…Castration resistant prostate cancer (CRPC) remains an incurable disease stage with ineffective treatments options. Here, the androgen receptor (AR)…”
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Troglitazone Regulates Peroxisome Proliferator-Activated Receptors and Inducible Nitric Oxide Synthase in Murine Ovarian Macrophages by MINGE, Cadence E, RYAN, Natalie K, VAN DER HOEK, Kylie H, ROBKER, Rebecca L, NORMAN, Robert J

“…Peroxisome proliferator-activated receptor-gamma (PPARG) and PPAR-alpha (PPARA) control metabolic processes in many cell types and act as anti-inflammatory…”
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Patient‐Derived Prostate Cancer Explants: A Clinically Relevant Model to Assess siRNA‐Based Nanomedicines by Tieu, Terence, Irani, Swati, Bremert, Kayla L., Ryan, Natalie K., Wojnilowicz, Marcin, Helm, Madison, Thissen, Helmut, Voelcker, Nicolas H., Butler, Lisa M., Cifuentes‐Rius, Anna

“…Over the last thirty years, research in nanomedicine has widely been focused on applications in cancer therapeutics. However, despite the plethora of reported…”
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Macrophage contributions to ovarian function by Wu, Ruijin, Van der Hoek, Kylie H., Ryan, Natalie K., Norman, Robert J., Robker, Rebecca L.

“…Macrophages are multifunctional cells that play key roles in the immune response and are abundant throughout female reproductive tissues. Macrophages are…”
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Antiandrogenic actions of medroxyprogesterone acetate on epithelial cells within normal human breast tissues cultured ex vivo by Ochnik, Aleksandra M, Moore, Nicole L, Jankovic-Karasoulos, Tanja, Bianco-Miotto, Tina, Ryan, Natalie K, Thomas, Mervyn R, Birrell, Stephen N, Butler, Lisa M, Tilley, Wayne D, Hickey, Theresa E

“…OBJECTIVEMedroxyprogesterone acetate (MPA), a component of combined estrogen-progestin therapy (EPT), has been associated with increased breast cancer risk in…”
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Characterization of the prostate cancer susceptibility gene KLF6 in human and mouse prostate cancers by Chiam, Karen, Ryan, Natalie K., Ricciardelli, Carmela, Day, Tanya K., Buchanan, Grant, Ochnik, Aleksandra M., Murti, Krisna, Selth, Luke A., Butler, Lisa M., Tilley, Wayne D., Bianco-Miotto, Tina

“…BACKGROUND Krüppel‐like factor (KLF) 6 is a candidate tumor suppressor gene in prostate cancer, but the mechanisms contributing to its loss of expression are…”
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Expression of Leptin and Its Receptor in the Murine Ovary: Possible Role in the Regulation of Oocyte Maturation1 by Ryan, Natalie K, Woodhouse, Carole M, Van der Hoek, Kylie H, Gilchrist, Robert B, Armstrong, David T, Norman, Robert J

“…Leptin is a product of the ob gene that is produced primarily by adipose tissue. Leptin and its receptors are found within the ovary, but it is unclear what…”
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Troglitazone Regulates Peroxisome Proliferator-Activated Receptors and Inducible Nitric Oxide Synthase in Murine Ovarian Macrophages1 by Minge, Cadence E, Ryan, Natalie K, Van Der Hoek, Kylie H, Robker, Rebecca L, Norman, Robert J

“…Peroxisome proliferator-activated receptor-gamma (PPARG) and PPAR-alpha (PPARA) control metabolic processes in many cell types and act as anti-inflammatory…”
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