Search Results - "Ryan, Michael C."

Indenylmetal Catalysis in Organic Synthesis by Trost, Barry M., Ryan, Michael C.

“…Synthetic organic chemists have a long‐standing appreciation for transition metal cyclopentadienyl complexes, of which many have been used as catalysts for…”
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Cu-Catalyzed Aerobic Oxidative N–N Coupling of Carbazoles and Diarylamines Including Selective Cross-Coupling by Ryan, Michael C, Martinelli, Joseph R, Stahl, Shannon S

“…A Cu-catalyzed method has been identified for aerobic oxidative dimerization of carbazoles and diarylamines to the corresponding N–N coupled bicarbazoles and…”
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Construction of Enantioenriched [3.1.0] Bicycles via a Ruthenium-Catalyzed Asymmetric Redox Bicycloisomerization Reaction by Trost, Barry M, Ryan, Michael C, Rao, Meera, Markovic, Tim Z

“…Enantiomerically enriched [3.1.0] bicycles containing vicinal quaternary centers were synthesized from [1,6]-enynes using a cyclopentadienylruthenium catalyst…”
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Diagnostic Discrepancies in Retinopathy of Prematurity Classification by Campbell, J. Peter, MD, MPH, Ryan, Michael C., MD, Lore, Emily, BA, Tian, Peng, BE, Ostmo, Susan, MS, Jonas, Karyn, RN, Chan, R.V. Paul, MD, Chiang, Michael F., MD

“…Purpose To identify the most common areas for discrepancy in retinopathy of prematurity (ROP) classification between experts. Design Prospective cohort study…”
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CHASM and SNVBox: toolkit for detecting biologically important single nucleotide mutations in cancer by Wong, Wing Chung, Kim, Dewey, Carter, Hannah, Diekhans, Mark, Ryan, Michael C., Karchin, Rachel

“…Thousands of cancer exomes are currently being sequenced, yielding millions of non-synonymous single nucleotide variants (SNVs) of possible relevance to…”
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Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome by Colla, Simona, Ong, Derrick Sek Tong, Ogoti, Yamini, Marchesini, Matteo, Mistry, Nipun A., Clise-Dwyer, Karen, Ang, Sonny A., Storti, Paola, Viale, Andrea, Giuliani, Nicola, Ruisaard, Kathryn, Ganan Gomez, Irene, Bristow, Christopher A., Estecio, Marcos, Weksberg, David C., Ho, Yan Wing, Hu, Baoli, Genovese, Giannicola, Pettazzoni, Piergiorgio, Multani, Asha S., Jiang, Shan, Hua, Sujun, Ryan, Michael C., Carugo, Alessandro, Nezi, Luigi, Wei, Yue, Yang, Hui, D’Anca, Marianna, Zhang, Li, Gaddis, Sarah, Gong, Ting, Horner, James W., Heffernan, Timothy P., Jones, Philip, Cooper, Laurence J.N., Liang, Han, Kantarjian, Hagop, Wang, Y. Alan, Chin, Lynda, Bueso-Ramos, Carlos, Garcia-Manero, Guillermo, DePinho, Ronald A.

“…Myelodysplastic syndrome (MDS) risk correlates with advancing age, therapy-induced DNA damage, and/or shorter telomeres, but whether telomere erosion directly…”
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Influence of Fluorescein Angiography on the Diagnosis and Management of Retinopathy of Prematurity by Klufas, Michael A., MD, Patel, Samir N., BS, Ryan, Michael C., MS, Patel Gupta, Mrinali, MD, Jonas, Karyn E., RN, Ostmo, Susan, MS, Martinez-Castellanos, Maria Ana, MD, Berrocal, Audina M., MD, Chiang, Michael F., MD, Chan, R.V. Paul, MD

“…Purpose To examine the influence of fluorescein angiography (FA) on the diagnosis and management of retinopathy of prematurity (ROP). Design Prospective cohort…”
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Interactive Clustered Heat Map Builder: An easy web-based tool for creating sophisticated clustered heat maps [version 2; peer review: 2 approved] by Ryan, Michael C, Stucky, Mark, Wakefield, Chris, Melott, James M, Akbani, Rehan, Weinstein, John N, Broom, Bradley M

“…Clustered heat maps are the most frequently used graphics for visualization and interpretation of genome-scale molecular profiling data in biology. …”
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Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p by SOLIER, Stéphanie, RYAN, Michael C, MARTIN, Scott E, VARMA, Sudhir, KOHN, Kurt W, HONGFANG LIU, ZEEBERG, Barry R, POMMIER, Yves

“…Topoisomerase I (Top1) relaxes DNA supercoiling by forming transient cleavage complexes (Top1cc) up- and downstream of transcription complexes. Top1cc can be…”
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Chiral cyclopentadienylruthenium sulfoxide catalysts for asymmetric redox bicycloisomerization by Trost, Barry M, Ryan, Michael C, Rao, Meera

“…A full account of our efforts toward an asymmetric redox bicycloisomerization reaction is presented in this article. Cyclopentadienylruthenium (CpRu) complexes…”
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Distinct epigenetic features of differentiation-regulated replication origins by Smith, Owen K, Kim, RyanGuk, Fu, Haiqing, Martin, Melvenia M, Lin, Chii Mei, Utani, Koichi, Zhang, Ya, Marks, Anna B, Lalande, Marc, Chamberlain, Stormy, Libbrecht, Maxwell W, Bouhassira, Eric E, Ryan, Michael C, Noble, William S, Aladjem, Mirit I

“…Eukaryotic genome duplication starts at discrete sequences (replication origins) that coordinate cell cycle progression, ensure genomic stability and modulate…”
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Feasibility and Clinical Utility of Ultra-Widefield–Navigated Swept-Source Optical Coherence Tomography Imaging by Kovacs, Kyle D., Mahrous, M. Abdallah, Gonzalez, Luis, Botsford, Benjamin E., Lenis, Tamara L., Ryan, Michael C., Orlin, Anton, Papakostas, Thanos D., D’Amico, Donald J., Kiss, Szilárd

“…Purpose: This work aims to evaluate the clinical utility and feasibility of a novel scanning laser ophthalmoscope-based navigated ultra-widefield swept-source…”
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AffyProbeMiner: a web resource for computing or retrieving accurately redefined Affymetrix probe sets by Liu, Hongfang, Zeeberg, Barry R., Qu, Gang, Koru, A. Gunes, Ferrucci, Alessandro, Kahn, Ari, Ryan, Michael C., Nuhanovic, Antej, Munson, Peter J., Reinhold, William C., Kane, David W., Weinstein, John N.

“…Motivation: Affymetrix microarrays are widely used to measure global expression of mRNA transcripts. That technology is based on the concept of a probe set…”
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SpliceSeq: a resource for analysis and visualization of RNA-Seq data on alternative splicing and its functional impacts by RYAN, Michael C, CLELAND, James, KIM, Ryangguk, WING CHUNG WONG, WEINSTEIN, John N

“…SpliceSeq is a resource for RNA-Seq data that provides a clear view of alternative splicing and identifies potential functional changes that result from splice…”
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Interactive Clustered Heat Map Builder: An easy web-based tool for creating sophisticated clustered heat maps [version 1; peer review: 1 approved, 1 approved with reservations] by Ryan, Michael C, Stucky, Mark, Wakefield, Chris, Melott, James M, Akbani, Rehan, Weinstein, John N, Broom, Bradley M

“…Clustered heat maps are the most frequently used graphics for visualization and interpretation of genome-scale molecular profiling data in biology. …”
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Copper/TEMPO Redox Redux: Analysis of PCET Oxidation of TEMPOH by Copper(II) and the Reaction of TEMPO with Copper(I) by Ryan, Michael C, Whitmire, Lauren D, McCann, Scott D, Stahl, Shannon S

“…Copper salts and organic aminoxyls, such as TEMPO (2,2,6,6-tetra­methyl­piper­idine-N-oxyl), are versatile catalysts for aerobic alcohol oxidation. Previous…”
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SpliceCenter: a suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies by Ryan, Michael C, Zeeberg, Barry R, Caplen, Natasha J, Cleland, James A, Kahn, Ari B, Liu, Hongfang, Weinstein, John N

“…Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses…”
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Ruthenium-Catalyzed Asymmetric Allylic Alkylation of Isatins by Trost, Barry M, Kalnmals, Christopher A, Ramakrishnan, Divya, Ryan, Michael C, Smaha, Rebecca W, Parkin, Sean

“…A new ruthenium-based catalytic system for branched-selective asymmetric allylic alkylation is disclosed and applied to the synthesis of chiral isatin…”
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CRAVAT 4: Cancer-Related Analysis of Variants Toolkit by Masica, David L, Douville, Christopher, Tokheim, Collin, Bhattacharya, Rohit, Kim, RyangGuk, Moad, Kyle, Ryan, Michael C, Karchin, Rachel

“…Cancer sequencing studies are increasingly comprehensive and well powered, returning long lists of somatic mutations that can be difficult to sort and…”
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A Ruthenium/Phosphoramidite-Catalyzed Asymmetric Interrupted Metallo-ene Reaction by Trost, Barry M, Ryan, Michael C

“…Allylic chlorides prepared from commercially available trans-1,4-dichloro-2-butene were converted to trans-disubstituted 5- and 6-membered ring systems with…”
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