Search Results - "Ryan, Kevin J"

Between Ecological Psychology and Enactivism: Is There Resonance? by Ryan, Kevin J., Gallagher, Shaun

“…Ecological psychologists and enactivists agree that the best explanation for a large share of cognition is non-representational in kind. In both ecological…”
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Cognitive modeling, ecological psychology, and musical improvisation by Ryan, Kevin J.

“…Understanding novelty and improvisation in music requires gathering insight from a variety of disciplines. One fruitful path for synthesizing these insights is…”
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Embodied Intelligence: Smooth Coping in the Learning Intelligent Decision Agent Cognitive Architecture by Kronsted, Christian, Kugele, Sean, Neemeh, Zachariah A, Ryan, Jr, Kevin J, Franklin, Stan

“…Much of our everyday, embodied action comes in the form of smooth coping. Smooth coping is skillful action that has become habituated and ingrained, generally…”
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G protein-coupled estrogen receptor regulates embryonic heart rate in zebrafish by Romano, Shannon N, Edwards, Hailey E, Souder, Jaclyn Paige, Ryan, Kevin J, Cui, Xiangqin, Gorelick, Daniel A

“…Estrogens act by binding to estrogen receptors alpha and beta (ERα, ERβ), ligand-dependent transcription factors that play crucial roles in sex…”
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Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center phase I study by Schaff, Lauren R, Lobbous, Mina, Carlow, Dean, Schofield, Ryan, Gavrilovic, Igor T, Miller, Alexandra M, Stone, Jacqueline B, Piotrowski, Anna F, Sener, Ugur, Skakodub, Anna, Acosta, Edward P, Ryan, Kevin J, Mellinghoff, Ingo K, DeAngelis, Lisa M, Nabors, Louis B, Grommes, Christian

“…High-dose methotrexate (HD-MTX) has broad use in the treatment of central nervous system (CNS) malignancies but confers significant toxicity without inpatient…”
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Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior by Umfress, Alan, Singh, Sarbjit, Ryan, Kevin J, Chakraborti, Ayanabha, Plattner, Florian, Sonawane, Yogesh, Mallareddy, Jayapal Reddy, Acosta, Edward P, Natarajan, Amarnath, Bibb, James A

“…Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction. Cdk5 activity is implicated in various neuropsychiatric and…”
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Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to adipose cells by Ryan, Kevin J P, Daniel, Zoe C T R, Craggs, Lucinda J L, Parr, Tim, Brameld, John M

“…Fat infiltration within muscle is one of a number of features of vitamin D deficiency, which leads to a decline in muscle functionality. The origin of this fat…”
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Angiotensin I Is Largely Converted to Angiotensin (1-7) and Angiotensin (2-10) by Isolated Rat Glomeruli by Velez, Juan Carlos Q, Ryan, Kevin J, Harbeson, Caroline E, Bland, Alison M, Budisavljevic, Milos N, Arthur, John M, Fitzgibbon, Wayne R, Raymond, John R, Janech, Michael G

“…Intraglomerular renin-angiotensin system enzyme activities have been examined previously using glomerular lysates and immune-based assays. However, preparation…”
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Effect of dietary conjugated linoleic acid isomers on lipid metabolism in hamsters fed high-carbohydrate and high-fat diets by Tarling, Elizabeth J, Ryan, Kevin J.P, Bennett, Andrew J, Salter, Andrew M

“…Dietary conjugated linoleic acids (CLA) have been reported to have a number of isomer-dependent effects on lipid metabolism including reduction in adipose…”
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Targeted Online Liquid Chromatography Electron Capture Dissociation Mass Spectrometry for the Localization of Sites of in Vivo Phosphorylation in Human Sprouty2 by Sweet, Steve M. M, Mardakheh, Faraz K, Ryan, Kevin J. P, Langton, Amy J, Heath, John K, Cooper, Helen J

“…We demonstrate a strategy employing collision-induced dissociation for phosphopeptide discovery, followed by targeted electron capture dissociation (ECD) for…”
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Quantitation of cystic fibrosis triple combination therapy, elexacaftor/tezacaftor/ivacaftor, in human plasma and cellular lysate by Ryan, Kevin J., Guimbellot, Jennifer S., Dowell, Alexander E., Reed-Walker, Kedria D., Kerstner-Wood, Corenna D., Anderson, Justin D., Liu, Zhongyu, Acosta, Edward P.

“…•Quantifies CFTR modulators in plasma and cellular lysate for research and clinical care.•Highly sensitive and optimized for very small sample…”
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Changes in protein profiles during course of experimental glomerulonephritis by Nazeer, Khurram, Janech, Michael G, Lin, Jim J-C, Ryan, Kevin J, Arthur, John M, Budisavljevic, Milos N

“…Better characterization of the molecular mechanisms underlying glomerular cell proliferation may improve our understanding of the pathogenesis of…”
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A phase I/II study of preoperative letrozole, everolimus, and carotuximab in stage 2 and 3 hormone receptor-positive and Her2-negative breast cancer by Vaklavas, Christos, Stringer-Reasor, Erica M., Elkhanany, Ahmed M., Ryan, Kevin J., Li, Yufeng, Theuer, Charles P., Acosta, Edward P., Wei, Shi, Yang, Eddy S., Grizzle, William E., Forero-Torres, Andres

“…Purpose In nonmetastatic hormone receptor-positive and Her2-negative breast cancer, preoperative endocrine therapies can yield outcomes similar with…”
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Ivacaftor-elexacaftor-tezacaftor and tacrolimus combination in cystic fibrosis by Smith, Megan, Ryan, Kevin J., Gutierrez, Hector, Sanchez, Luz Helena Gutierrez, Anderson, Janaina Nogueira, Acosta, Edward P., Benner, Kim W., Guimbellot, Jennifer S.

“…•Highly effective modulator treatment results in improvement in clinical outcomes.•Modulator use may result in drug interactions that need to be…”
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Variable cellular ivacaftor concentrations in people with cystic fibrosis on modulator therapy by Guimbellot, Jennifer S., Ryan, Kevin J., Anderson, Justin D., Liu, Zhongyu, Kersh, Latona, Esther, Charles R., Rowe, Steven M., Acosta, Edward P.

“…•An LC-MS/MS assay was developed to quantitate CFTR modulators in epithelial cells and in plasma for clinical purposes and mechanistic studies.•This pilot…”
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Plasma and cellular ivacaftor concentrations in patients with cystic fibrosis by Guimbellot, Jennifer S., Ryan, Kevin J., Anderson, Justin D., Parker, Kennedy L., Victoria Odom, Lauren, Rowe, Steven M., Acosta, Edward P.

“…Access to cystic fibrosis transmembrane conductance regulator (CFTR) modulators has been gradually increasing for people with cystic fibrosis, the first of…”
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Differential distribution of ivacaftor and its metabolites in plasma and human airway epithelia by Liu, Zhongyu, Anderson, Justin D., Rose, Natalie R., Baker, Elizabeth H., Dowell, Alexander E., Ryan, Kevin J., Acosta, Edward P., Guimbellot, Jennifer S.

“…Ivacaftor is the first clinically approved monotherapy potentiator to treat CFTR channel dysfunction in people with cystic fibrosis. Ivacaftor (Iva) is a…”
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Pharmacokinetic variability of CFTR modulators from standard and alternative regimens by Rose, Natalie R., Chalamalla, Ashritha R., Garcia, Bryan A., Krick, Stefanie, Bergeron, Jonathan, Sadeghi, Hossein, Schellhase, Dennis E., Ryan, Kevin J., Dowell, Alexander E., Acosta, Edward P., Guimbellot, Jennifer S.

“…Elexacaftor, tezacaftor, ivacaftor (ETI) is a CFTR modulator combination approved for use in ∼90 % of people with cystic fibrosis (pwCF) over 2 years old…”
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Genital Shedding of Human Immunodeficiency Virus Type-1 (HIV) When Antiretroviral Therapy Suppresses HIV Replication in the Plasma by Bull, Marta, Mitchell, Caroline, Soria, Jaime, Styrchak, Sheila, Williams, Corey, Dragavon, Joan, Ryan, Kevin J, Acosta, Edward, Onchiri, Frankline, Coombs, Robert W, La Rosa, Alberto, Ticona, Eduardo, Frenkel, Lisa M

“…Abstract Background During antiretroviral treatment (ART) with plasma HIV RNA below the limit of quantification, HIV RNA can be detected in genital or rectal…”
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Turbulent Scalar Mixing in a Skewed Jet in Crossflow: Experiments and Modeling by Ryan, Kevin J., Bodart, Julien, Folkersma, Mikko, Elkins, Christopher J., Eaton, John K.

“…Turbulent mixing of an inclined, skewed jet injected into a crossflow is investigated using MRI-based experiments and a high-fidelity LES of the same…”
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