Search Results - "Ryan, Dylan G"

Krebs Cycle Reborn in Macrophage Immunometabolism by Ryan, Dylan G, O'Neill, Luke A.J

“…A striking change has happened in the field of immunology whereby specific metabolic processes have been shown to be a critical determinant of immune cell…”
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A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia by Baardman, Jeroen, Verberk, Sanne G.S., Prange, Koen H.M., van Weeghel, Michel, van der Velden, Saskia, Ryan, Dylan G., Wüst, Rob C.I., Neele, Annette E., Speijer, Dave, Denis, Simone W., Witte, Maarten E., Houtkooper, Riekelt H., O’neill, Luke A., Knatko, Elena V., Dinkova-Kostova, Albena T., Lutgens, Esther, de Winther, Menno P.J., Van den Bossche, Jan

“…Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and…”
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Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response by Ryan, Dylan G., Knatko, Elena V., Casey, Alva M., Hukelmann, Jens L., Dayalan Naidu, Sharadha, Brenes, Alejandro J., Ekkunagul, Thanapon, Baker, Christa, Higgins, Maureen, Tronci, Laura, Nikitopolou, Efterpi, Honda, Tadashi, Hartley, Richard C., O’Neill, Luke A.J., Frezza, Christian, Lamond, Angus I., Abramov, Andrey Y., Arthur, J. Simon C., Cantrell, Doreen A., Murphy, Michael P., Dinkova-Kostova, Albena T.

“…To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2…”
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Inflammatory mitochondrial nucleic acids as drivers of pathophysiology by Peace, Christian G, Hooftman, Alexander, Ryan, Dylan G

“…Mitochondria are intracellular membrane-bound organelles that harness the chemical energy in food to drive adenosine triphosphate (ATP) synthesis via oxidative…”
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DIA label-free proteomic analysis of murine bone-marrow-derived macrophages by Baker, Christa P., Phair, Iain R., Brenes, Alejandro J., Atrih, Abdelmadjid, Ryan, Dylan G., Bruderer, Roland, Dinkova-Kostova, Albena T., Lamont, Douglas J., Arthur, J. Simon C., Howden, Andrew J.M.

“…Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We…”
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TCA cycle signalling and the evolution of eukaryotes by Ryan, Dylan G, Frezza, Christian, O’Neill, Luke AJ

“…A major question remaining in the field of evolutionary biology is how prokaryotic organisms made the leap to complex eukaryotic life. The prevailing theory…”
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Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2 by Early, James O., Menon, Deepthi, Wyse, Cathy A., Cervantes-Silva, Mariana P., Zaslona, Zbigniew, Carroll, Richard G., Palsson-McDermott, Eva M., Angiari, Stefano, Ryan, Dylan G., Corcoran, Sarah E., Timmons, George, Geiger, Sarah S., Fitzpatrick, Darren J., O’Connell, Daniel, Xavier, Ramnik J., Hokamp, Karsten, O’Neill, Luke A. J., Curtis, Annie M.

“…A variety of innate immune responses and functions are dependent on time of day, and many inflammatory conditions are associated with dysfunctional molecular…”
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Coupling Krebs cycle metabolites to signalling in immunity and cancer by Ryan, Dylan G., Murphy, Michael P., Frezza, Christian, Prag, Hiran A., Chouchani, Edward T., O’Neill, Luke A., Mills, Evanna L.

“…Metabolic reprogramming has become a key focus for both immunologists and cancer biologists, with exciting advances providing new insights into the mechanisms…”
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Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming by Olagnier, David, Brandtoft, Aske M., Gunderstofte, Camilla, Villadsen, Nikolaj L., Krapp, Christian, Thielke, Anne L., Laustsen, Anders, Peri, Suraj, Hansen, Anne Louise, Bonefeld, Lene, Thyrsted, Jacob, Bruun, Victor, Iversen, Marie B., Lin, Lin, Artegoitia, Virginia M., Su, Chenhe, Yang, Long, Lin, Rongtuan, Balachandran, Siddharth, Luo, Yonglun, Nyegaard, Mette, Marrero, Bernadette, Goldbach-Mansky, Raphaela, Motwani, Mona, Ryan, Dylan G., Fitzgerald, Katherine A., O’Neill, Luke A., Hollensen, Anne K., Damgaard, Christian K., de Paoli, Frank v., Bertram, Hanne C., Jakobsen, Martin R., Poulsen, Thomas B., Holm, Christian K.

“…The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2 also affects cytosolic nucleic acid sensing is currently…”
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Macrophage fumarate hydratase restrains mtRNA-mediated interferon production by Hooftman, Alexander, Peace, Christian G., Ryan, Dylan G., Day, Emily A., Yang, Ming, McGettrick, Anne F., Yin, Maureen, Montano, Erica N., Huo, Lihong, Toller-Kawahisa, Juliana E., Zecchini, Vincent, Ryan, Tristram A. J., Bolado-Carrancio, Alfonso, Casey, Alva M., Prag, Hiran A., Costa, Ana S. H., De Los Santos, Gabriela, Ishimori, Mariko, Wallace, Daniel J., Venuturupalli, Swamy, Nikitopoulou, Efterpi, Frizzell, Norma, Johansson, Cecilia, Von Kriegsheim, Alexander, Murphy, Michael P., Jefferies, Caroline, Frezza, Christian, O’Neill, Luke A. J.

“…Metabolic rewiring underlies the effector functions of macrophages 1 – 3 , but the mechanisms involved remain incompletely defined. Here, using unbiased…”
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Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages by Williams, Niamh C., Ryan, Dylan G., Costa, Ana S.H., Mills, Evanna L., Jedrychowski, Mark P., Cloonan, Suzanne M., Frezza, Christian, O'Neill, Luke A.

“…Activated macrophages undergo metabolic reprogramming, which not only supports their energetic demands but also allows for the production of specific…”
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Caspase-11 promotes allergic airway inflammation by Zasłona, Zbigniew, Flis, Ewelina, Wilk, Mieszko M., Carroll, Richard G., Palsson-McDermott, Eva M., Hughes, Mark M., Diskin, Ciana, Banahan, Kathy, Ryan, Dylan G., Hooftman, Alexander, Misiak, Alicja, Kearney, Jay, Lochnit, Gunter, Bertrams, Wilhelm, Greulich, Timm, Schmeck, Bernd, McElvaney, Oliver J., Mills, Kingston H. G., Lavelle, Ed C., Wygrecka, Małgorzata, Creagh, Emma M., O’Neill, Luke A. J.

“…Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E 2 (PGE 2 ) inhibits…”
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High-dimensional single-cell analysis of human natural killer cell heterogeneity by Rebuffet, Lucas, Melsen, Janine E., Escalière, Bertrand, Basurto-Lozada, Daniela, Bhandoola, Avinash, Björkström, Niklas K., Bryceson, Yenan T., Castriconi, Roberta, Cichocki, Frank, Colonna, Marco, Davis, Daniel M., Diefenbach, Andreas, Ding, Yi, Haniffa, Muzlifah, Horowitz, Amir, Lanier, Lewis L., Malmberg, Karl-Johan, Miller, Jeffrey S., Moretta, Lorenzo, Narni-Mancinelli, Emilie, O’Neill, Luke A. J., Romagnani, Chiara, Ryan, Dylan G., Sivori, Simona, Sun, Dan, Vagne, Constance, Vivier, Eric

“…Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their classification hinged…”
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Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling by Hughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., C. Williams, Niamh, Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan, O’Neill, Luke A. J.

“…MyD88 adaptor-like (MAL) is a critical protein in innate immunity, involved in signaling by several Toll-like receptors (TLRs), key pattern recognition…”
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Multifaceted mitochondria in innate immunity by Marques, Eloïse, Kramer, Robbin, Ryan, Dylan G

“…The ability of mitochondria to transform the energy we obtain from food into cell phosphorylation potential has long been appreciated. However, recent decades…”
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 by Mills, Evanna L., Ryan, Dylan G., Prag, Hiran A., Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P., Costa, Ana S. H., Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C., King, Martin S., McGouran, Joanna F., Fischer, Roman, Kessler, Benedikt M., McGettrick, Anne F., Hughes, Mark M., Carroll, Richard G., Booty, Lee M., Knatko, Elena V., Meakin, Paul J., Ashford, Michael L. J., Modis, Louise K., Brunori, Gino, Sévin, Daniel C., Fallon, Padraic G., Caldwell, Stuart T., Kunji, Edmund R. S., Chouchani, Edward T., Frezza, Christian, Dinkova-Kostova, Albena T., Hartley, Richard C., Murphy, Michael P., O’Neill, Luke A.

“…WebTreatment of lipopolysaccharide-activated macrophages with the cell-permeable itaconate derivative 4-octyl itaconate activates the anti-inflammatory…”
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Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism by Ryan, Dylan Gerard, Yang, Ming, Prag, Hiran A, Blanco, Giovanny Rodriguez, Nikitopoulou, Efterpi, Segarra-Mondejar, Marc, Powell, Christopher A, Young, Tim, Burger, Nils, Miljkovic, Jan Lj, Minczuk, Michal, Murphy, Michael P, von Kriegsheim, Alex, Frezza, Christian

“…The Tricarboxylic Acid (TCA) Cycle is arguably the most critical metabolic cycle in physiology and exists as an essential interface coordinating cellular…”
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Circadian clock protein BMAL1 regulates IL-1ß in macrophages via NRF2 by Early, James O, Menon, Deepthi, Wyse, Cathy A, Cervantes-Silva, Mariana P, Zaslona, Zbigniew, Carroll, Richard G, Palsson-McDermott, Eva M, Angiari, Stefano, Ryan, Dylan G, Corcoran, Sarah E, Timmons, George, Geiger, Sarah S, Fitzpatrick, Darren J, O’Connell, Daniel, Xavier, Ramnik J, Hokamp, Karsten, O’Neill, Luke A J, Curtis, Annie M

“…A variety of innate immune responses and functions are dependent on time of day, and many inflammatory conditions are associated with dysfunctional molecular…”
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