Search Results - "Ryan, Dylan"

Krebs Cycle Reborn in Macrophage Immunometabolism by Ryan, Dylan G, O'Neill, Luke A.J

“…A striking change has happened in the field of immunology whereby specific metabolic processes have been shown to be a critical determinant of immune cell…”
Get full text

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages by Mills, Evanna L., Kelly, Beth, Logan, Angela, Costa, Ana S.H., Varma, Mukund, Bryant, Clare E., Tourlomousis, Panagiotis, Däbritz, J. Henry M., Gottlieb, Eyal, Latorre, Isabel, Corr, Sinéad C., McManus, Gavin, Ryan, Dylan, Jacobs, Howard T., Szibor, Marten, Xavier, Ramnik J., Braun, Thomas, Frezza, Christian, Murphy, Michael P., O’Neill, Luke A.

“…Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory phenotype, but the mechanistic basis for this remains obscure. Here,…”
Get full text

TCA cycle signalling and the evolution of eukaryotes by Ryan, Dylan G, Frezza, Christian, O’Neill, Luke AJ

“…A major question remaining in the field of evolutionary biology is how prokaryotic organisms made the leap to complex eukaryotic life. The prevailing theory…”
Get full text

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2 by Early, James O., Menon, Deepthi, Wyse, Cathy A., Cervantes-Silva, Mariana P., Zaslona, Zbigniew, Carroll, Richard G., Palsson-McDermott, Eva M., Angiari, Stefano, Ryan, Dylan G., Corcoran, Sarah E., Timmons, George, Geiger, Sarah S., Fitzpatrick, Darren J., O’Connell, Daniel, Xavier, Ramnik J., Hokamp, Karsten, O’Neill, Luke A. J., Curtis, Annie M.

“…A variety of innate immune responses and functions are dependent on time of day, and many inflammatory conditions are associated with dysfunctional molecular…”
Get full text

Coupling Krebs cycle metabolites to signalling in immunity and cancer by Ryan, Dylan G., Murphy, Michael P., Frezza, Christian, Prag, Hiran A., Chouchani, Edward T., O’Neill, Luke A., Mills, Evanna L.

“…Metabolic reprogramming has become a key focus for both immunologists and cancer biologists, with exciting advances providing new insights into the mechanisms…”
Get full text

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production by Hooftman, Alexander, Peace, Christian G., Ryan, Dylan G., Day, Emily A., Yang, Ming, McGettrick, Anne F., Yin, Maureen, Montano, Erica N., Huo, Lihong, Toller-Kawahisa, Juliana E., Zecchini, Vincent, Ryan, Tristram A. J., Bolado-Carrancio, Alfonso, Casey, Alva M., Prag, Hiran A., Costa, Ana S. H., De Los Santos, Gabriela, Ishimori, Mariko, Wallace, Daniel J., Venuturupalli, Swamy, Nikitopoulou, Efterpi, Frizzell, Norma, Johansson, Cecilia, Von Kriegsheim, Alexander, Murphy, Michael P., Jefferies, Caroline, Frezza, Christian, O’Neill, Luke A. J.

“…Metabolic rewiring underlies the effector functions of macrophages 1 – 3 , but the mechanisms involved remain incompletely defined. Here, using unbiased…”
Get full text

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia by Baardman, Jeroen, Verberk, Sanne G.S., Prange, Koen H.M., van Weeghel, Michel, van der Velden, Saskia, Ryan, Dylan G., Wüst, Rob C.I., Neele, Annette E., Speijer, Dave, Denis, Simone W., Witte, Maarten E., Houtkooper, Riekelt H., O’neill, Luke A., Knatko, Elena V., Dinkova-Kostova, Albena T., Lutgens, Esther, de Winther, Menno P.J., Van den Bossche, Jan

“…Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and…”
Get full text

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism by Ryan, Dylan Gerard, Yang, Ming, Prag, Hiran A, Blanco, Giovanny Rodriguez, Nikitopoulou, Efterpi, Segarra-Mondejar, Marc, Powell, Christopher A, Young, Tim, Burger, Nils, Miljkovic, Jan Lj, Minczuk, Michal, Murphy, Michael P, von Kriegsheim, Alex, Frezza, Christian

“…The Tricarboxylic Acid (TCA) Cycle is arguably the most critical metabolic cycle in physiology and exists as an essential interface coordinating cellular…”
Get full text

Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages by Williams, Niamh C., Ryan, Dylan G., Costa, Ana S.H., Mills, Evanna L., Jedrychowski, Mark P., Cloonan, Suzanne M., Frezza, Christian, O'Neill, Luke A.

“…Activated macrophages undergo metabolic reprogramming, which not only supports their energetic demands but also allows for the production of specific…”
Get full text

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response by Ryan, Dylan G., Knatko, Elena V., Casey, Alva M., Hukelmann, Jens L., Dayalan Naidu, Sharadha, Brenes, Alejandro J., Ekkunagul, Thanapon, Baker, Christa, Higgins, Maureen, Tronci, Laura, Nikitopolou, Efterpi, Honda, Tadashi, Hartley, Richard C., O’Neill, Luke A.J., Frezza, Christian, Lamond, Angus I., Abramov, Andrey Y., Arthur, J. Simon C., Cantrell, Doreen A., Murphy, Michael P., Dinkova-Kostova, Albena T.

“…To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2…”
Get full text

Inflammatory mitochondrial nucleic acids as drivers of pathophysiology by Peace, Christian G, Hooftman, Alexander, Ryan, Dylan G

“…Mitochondria are intracellular membrane-bound organelles that harness the chemical energy in food to drive adenosine triphosphate (ATP) synthesis via oxidative…”
Get full text

High-dimensional single-cell analysis of human natural killer cell heterogeneity by Rebuffet, Lucas, Melsen, Janine E., Escalière, Bertrand, Basurto-Lozada, Daniela, Bhandoola, Avinash, Björkström, Niklas K., Bryceson, Yenan T., Castriconi, Roberta, Cichocki, Frank, Colonna, Marco, Davis, Daniel M., Diefenbach, Andreas, Ding, Yi, Haniffa, Muzlifah, Horowitz, Amir, Lanier, Lewis L., Malmberg, Karl-Johan, Miller, Jeffrey S., Moretta, Lorenzo, Narni-Mancinelli, Emilie, O’Neill, Luke A. J., Romagnani, Chiara, Ryan, Dylan G., Sivori, Simona, Sun, Dan, Vagne, Constance, Vivier, Eric

“…Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their classification hinged…”
Get full text

Krebs cycle rewired for macrophage and dendritic cell effector functions by Ryan, Dylan Gerard, O'Neill, Luke A. J.

“…The Krebs cycle is an amphibolic pathway operating in the mitochondrial matrix of all eukaryotic organisms. In response to proinflammatory stimuli, macrophages…”
Get full text

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling by Hughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., C. Williams, Niamh, Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan, O’Neill, Luke A. J.

“…MyD88 adaptor-like (MAL) is a critical protein in innate immunity, involved in signaling by several Toll-like receptors (TLRs), key pattern recognition…”
Get full text

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming by Olagnier, David, Brandtoft, Aske M., Gunderstofte, Camilla, Villadsen, Nikolaj L., Krapp, Christian, Thielke, Anne L., Laustsen, Anders, Peri, Suraj, Hansen, Anne Louise, Bonefeld, Lene, Thyrsted, Jacob, Bruun, Victor, Iversen, Marie B., Lin, Lin, Artegoitia, Virginia M., Su, Chenhe, Yang, Long, Lin, Rongtuan, Balachandran, Siddharth, Luo, Yonglun, Nyegaard, Mette, Marrero, Bernadette, Goldbach-Mansky, Raphaela, Motwani, Mona, Ryan, Dylan G., Fitzgerald, Katherine A., O’Neill, Luke A., Hollensen, Anne K., Damgaard, Christian K., de Paoli, Frank v., Bertram, Hanne C., Jakobsen, Martin R., Poulsen, Thomas B., Holm, Christian K.

“…The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2 also affects cytosolic nucleic acid sensing is currently…”
Get full text

DIA label-free proteomic analysis of murine bone-marrow-derived macrophages by Baker, Christa P., Phair, Iain R., Brenes, Alejandro J., Atrih, Abdelmadjid, Ryan, Dylan G., Bruderer, Roland, Dinkova-Kostova, Albena T., Lamont, Douglas J., Arthur, J. Simon C., Howden, Andrew J.M.

“…Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We…”
Get full text

Massive hemoptysis bridged with VV ECMO: A case report by Ryan, Dylan, Miller, Kathleen, Capaldi, Carly, Pasquarello, Claudine, Yang, Qiong, Hirose, Hitoshi

“…Objective Extracorporeal membrane oxygenation (ECMO) can provide full pulmonary support when a patient is completely apneic. The combination of veno-venous…”
Get full text

Basic Mechanisms of Immunometabolites in Shaping the Immune Response by Ryan, Dylan Gerard, Peace, Christian Graham, Hooftman, Alexander

“…Abstract Background: Innate immune cells play a crucial role in responding to microbial infections, but their improper activation can also drive inflammatory…”
Get full text

Prolonged Allograft Survival in a Patient With Chronic Immunosuppression: A Case Report and Systematic Review by Vyas, Krishna S, Burns, Chase, Ryan, Dylan T, Wong, Lesley

“…A 41-year-old man with past medical history of kidney-liver transplantation requiring chronic immunosuppression presented 2 years posttransplant with a…”
Get full text

Caspase-11 promotes allergic airway inflammation by Zasłona, Zbigniew, Flis, Ewelina, Wilk, Mieszko M., Carroll, Richard G., Palsson-McDermott, Eva M., Hughes, Mark M., Diskin, Ciana, Banahan, Kathy, Ryan, Dylan G., Hooftman, Alexander, Misiak, Alicja, Kearney, Jay, Lochnit, Gunter, Bertrams, Wilhelm, Greulich, Timm, Schmeck, Bernd, McElvaney, Oliver J., Mills, Kingston H. G., Lavelle, Ed C., Wygrecka, Małgorzata, Creagh, Emma M., O’Neill, Luke A. J.

“…Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E 2 (PGE 2 ) inhibits…”
Get full text