Search Results - "Ryan, Devon P"

snakePipes: facilitating flexible, scalable and integrative epigenomic analysis by Bhardwaj, Vivek, Heyne, Steffen, Sikora, Katarzyna, Rabbani, Leily, Rauer, Michael, Kilpert, Fabian, Richter, Andreas S, Ryan, Devon P, Manke, Thomas

“…Abstract Summary Due to the rapidly increasing scale and diversity of epigenomic data, modular and scalable analysis workflows are of wide interest. Here we…”
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Rapamycin extends murine lifespan but has limited effects on aging by Neff, Frauke, Flores-Dominguez, Diana, Ryan, Devon P, Horsch, Marion, Schröder, Susanne, Adler, Thure, Afonso, Luciana Caminha, Aguilar-Pimentel, Juan Antonio, Becker, Lore, Garrett, Lillian, Hans, Wolfgang, Hettich, Moritz M, Holtmeier, Richard, Hölter, Sabine M, Moreth, Kristin, Prehn, Cornelia, Puk, Oliver, Rácz, Ildikó, Rathkolb, Birgit, Rozman, Jan, Naton, Beatrix, Ordemann, Rainer, Adamski, Jerzy, Beckers, Johannes, Bekeredjian, Raffi, Busch, Dirk H, Ehninger, Gerhard, Graw, Jochen, Höfler, Heinz, Klingenspor, Martin, Klopstock, Thomas, Ollert, Markus, Stypmann, Jörg, Wolf, Eckhard, Wurst, Wolfgang, Zimmer, Andreas, Fuchs, Helmut, Gailus-Durner, Valérie, Hrabe de Angelis, Martin, Ehninger, Dan

“…Aging is a major risk factor for a large number of disorders and functional impairments. Therapeutic targeting of the aging process may therefore represent an…”
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Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice by Xie, Kan, Ryan, Devon P., Pearson, Brandon L., Henzel, Kristin S., Neff, Frauke, Vidal, Ramon O., Hennion, Magali, Lehmann, Isabelle, Schleif, Melvin, Schröder, Susanne, Adler, Thure, Rathkolb, Birgit, Rozman, Jan, Schütz, Anna-Lena, Prehn, Cornelia, Mickael, Michel E., Weiergräber, Marco, Adamski, Jerzy, Busch, Dirk H., Ehninger, Gerhard, Matynia, Anna, Jackson, Walker S., Wolf, Eckhard, Fuchs, Helmut, Gailus-Durner, Valerie, Bonn, Stefan, de Angelis, Martin Hrabě, Ehninger, Dan

“…Advanced age is not only a major risk factor for a range of disorders within an aging individual but may also enhance susceptibility for disease in the next…”
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Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice by Xie, Kan, Neff, Frauke, Markert, Astrid, Rozman, Jan, Aguilar-Pimentel, Juan Antonio, Amarie, Oana Veronica, Becker, Lore, Brommage, Robert, Garrett, Lillian, Henzel, Kristin S., Hölter, Sabine M., Janik, Dirk, Lehmann, Isabelle, Moreth, Kristin, Pearson, Brandon L., Racz, Ildiko, Rathkolb, Birgit, Ryan, Devon P., Schröder, Susanne, Treise, Irina, Bekeredjian, Raffi, Busch, Dirk H., Graw, Jochen, Ehninger, Gerhard, Klingenspor, Martin, Klopstock, Thomas, Ollert, Markus, Sandholzer, Michael, Schmidt-Weber, Carsten, Weiergräber, Marco, Wolf, Eckhard, Wurst, Wolfgang, Zimmer, Andreas, Gailus-Durner, Valerie, Fuchs, Helmut, Hrabě de Angelis, Martin, Ehninger, Dan

“…Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is…”
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The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex by Hettich, Moritz M, Matthes, Frank, Ryan, Devon P, Griesche, Nadine, Schröder, Susanne, Dorn, Stephanie, Krauβ, Sybille, Ehninger, Dan

“…Alzheimer's disease (AD), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are…”
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Mutations in Potassium Channel Kir2.6 Cause Susceptibility to Thyrotoxic Hypokalemic Periodic Paralysis by Ryan, Devon P., Dias da Silva, Magnus R., Soong, Tuck Wah, Fontaine, Bertrand, Donaldson, Matt R., Kung, Annie W.C., Jongjaroenprasert, Wallaya, Liang, Mui Cheng, Khoo, Daphne H.C., Cheah, Jin Seng, Ho, Su Chin, Bernstein, Harold S., Maciel, Rui M.B., Brown, Robert H., Ptáček, Louis J.

“…Thyrotoxic hypokalemic periodic paralysis (TPP) is characterized by acute attacks of weakness, hypokalemia, and thyrotoxicosis of various etiologies. These…”
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High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice by Henzel, Kristin S., Ryan, Devon P., Schröder, Susanne, Weiergräber, Marco, Ehninger, Dan

“…Maternal folic acid (FA) supplementation prior to and during gestation is recommended for the prevention of neural tube closure defects in the developing…”
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deepTools2: a next generation web server for deep-sequencing data analysis by Ramírez, Fidel, Ryan, Devon P, Grüning, Björn, Bhardwaj, Vivek, Kilpert, Fabian, Richter, Andreas S, Heyne, Steffen, Dündar, Friederike, Manke, Thomas

“…We present an update to our Galaxy-based web server for processing and visualizing deeply sequenced data. Its core tool set, deepTools, allows users to perform…”
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Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome by Paesler, Katharina, Schnell, Susanne, Ryan, Devon P., Hettich, Moritz M., Heinen, Markus, Ehninger, Dan

“…Down syndrome is caused by triplication of chromosome 21 and is associated with neurocognitive phenotypes ranging from severe intellectual disability to…”
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Limited Effects of an eIF2αS51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer’s Disease by Müller, Ralf, Garthe, Alexander, Kempermann, Gerd, Weiergräber, Marco, Ehninger, Dan, Broich, Karl, Papazoglou, Anna, Schröder, Susanne, Ryan, Devon P., Siwek, Magdalena Elisabeth, Hettich, Moritz M., Xie, Kan, Paesler, Katharina, Trog, Astrid

“…Alzheimer’s disease (AD) has been associated with increased phosphorylation of the translation initiation factor 2α (eIF2α) at serine 51. Increased…”
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Episodic Neurological Channelopathies by Ryan, Devon P., Ptáček, Louis J.

“…Inherited episodic neurological disorders are often due to mutations in ion channels or their interacting proteins, termed channelopathies. There are a wide…”
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The anti-diabetic drug metformin improves cognitive impairment and reduces amyloid-beta in a mouse model of Alzheimer’s disease by Matthes, Frank, Hettich, Moritz M, Ryan, Devon P, Ehninger, Dan, Krauss, Sybille

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Giant excised patch recordings of recombinant ion channel currents expressed in mammalian cells by Couey, Jonathan J., Ryan, Devon P., Glover, John T., Dreixler, John C., Young, Joseph B., Houamed, Khaled M.

“…The giant excised patch variant of patch clamp recording combines microsecond time resolution of macroscopic currents with rapid exchange of the experimental…”
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P4‐173: The anti‐diabetic drug metformin improves cognitive impairment and reduces amyloid‐beta in a mouse model of Alzheimer's disease by Matthes, Frank, Hettich, Moritz M., Ryan, Devon P., Ehninger, Dan, Krauss, Sybille

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Characterization of a novel inwardly rectifying potassium channel (Kir2.6) and its role in thyrotoxic hypokalemic periodic paralysis by Ryan, Devon P

“…Thyrotoxic hypokalemic periodic paralysis (TPP) is characterized by periodic bouts of paralysis or weakness concomitant with hyperthyroidism of any source. TPP…”
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Characterization of a novel inwardly rectifying potassium channel (Kir2.6) and its role in thyrotoxic hypokalemic periodic paralysis by Ryan, Devon P

“…Thyrotoxic hypokalemic periodic paralysis (TPP) is characterized by periodic bouts of paralysis or weakness concomitant with hyperthyroidism of any source. TPP…”
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