Search Results - "Ryan, Carol"

Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils by Kirchgessner, Todd G., Sleph, Paul, Ostrowski, Jacek, Lupisella, John, Ryan, Carol S., Liu, Xiaoqin, Fernando, Gayani, Grimm, Denise, Shipkova, Petia, Zhang, Rongan, Garcia, Ricardo, Zhu, Jun, He, Aiqing, Malone, Harold, Martin, Richard, Behnia, Kamelia, Wang, Zhaoqing, Barrett, Yu Chen, Garmise, Robert J., Yuan, Long, Zhang, Jane, Gandhi, Mohit D., Wastall, Philip, Li, Tong, Du, Shuyan, Salvador, Lisa, Mohan, Raju, Cantor, Glenn H., Kick, Ellen, Lee, John, Frost, Robert J.A.

“…The development of LXR agonists for the treatment of coronary artery disease has been challenged by undesirable properties in animal models. Here we show the…”
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P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development by Garcia, Ricardo A, Yan, Mujing, Search, Debra, Zhang, Rongan, Carson, Nancy L, Ryan, Carol S, Smith-Monroy, Constance, Zheng, Joanna, Chen, Jian, Kong, Yan, Tang, Huaping, Hellings, Samuel E, Wardwell-Swanson, Judith, Dinchuk, Joseph E, Psaltis, George C, Gordon, David A, Glunz, Peter W, Gargalovic, Peter S

“…P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and…”
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A novel approach to measuring macrophage-specific reverse cholesterol transport in vivo in humans by Cuchel, Marina, Raper, Anna C., Conlon, Donna M., Pryma, Daniel A., Freifelder, Richard H., Poria, Rahul, Cromley, Debra, Li, Xiaoyu, Dunbar, Richard L., French, Benjamin, Qu, Liming, Farver, William, Su, Ching-Chiang, Lund-Katz, Sissel, Baer, Amanda, Ruotolo, Giacomo, Akerblad, Peter, Ryan, Carol S., Xiao, Lan, Kirchgessner, Todd G., Millar, John S., Billheimer, Jeffrey T., Rader, Daniel J.

“…Reverse cholesterol transport (RCT) is thought to be an atheroprotective function of HDL, and macrophage-specific RCT in mice is inversely associated with…”
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Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression by Parker, Rex A., Garcia, Ricardo, Ryan, Carol S., Liu, Xiaoqin, Shipkova, Petia, Livanov, Valentin, Patel, Pritesh, Ho, Siew P.

“…Proprotein convertase subtilisin-kexin-9 (PCSK9) inhibition markedly augments the LDL lowering action of statins. The combination is being evaluated for…”
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Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction by García, Ricardo A., Lupisella, John A., Ito, Bruce R., Hsu, Mei-Yin, Fernando, Gayani, Carson, Nancy L., Allocco, John J., Ryan, Carol S., Zhang, Rongan, Wang, Zhaoqing, Heroux, Madeleine, Carrier, Marilyn, St.-Onge, Stéphane, Bouvier, Michel, Dudhgaonkar, Shailesh, Nagar, Jignesh, Bustamante-Pozo, Moises M., Garate-Carrillo, Alejandra, Chen, Jian, Ma, Xiuying, Search, Debra J., Dierks, Elizabeth A., Kick, Ellen K., Wexler, Ruth R., Gordon, David A., Ostrowski, Jacek, Wurtz, Nicholas R., Villarreal, Francisco

“…[Display omitted] •MI leads to ischemic damage of myocardium and activation of inflammatory programs as part of the wound healing response.•Selective…”
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Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment by García, Ricardo A., Ito, Bruce R., Lupisella, John A., Carson, Nancy A., Hsu, Mei-Yin, Fernando, Gayani, Heroux, Madeleine, Bouvier, Michel, Dierks, Elizabeth, Kick, Ellen K., Gordon, David A., Chen, Jian, Mintier, Gabe, Carrier, Marilyn, St-Onge, Stéphane, Shah, Himanshu, Towne, Jordan, Bucardo, Marcela Sotelo, Ma, Xiuying, Ryan, Carol S., Wurtz, Nicholas R., Ostrowski, Jacek, Villarreal, Francisco J.

“…[Display omitted] •Myocardial infarction leads to recruitment of monocyte/macrophages to the injured myocardium to drive infarct healing.•Activation of formyl…”
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Molecular Mechanisms of Desensitization Underlying the Differential Effects of Formyl Peptide Receptor 2 Agonists on Cardiac Structure–Function Post Myocardial Infarction by Lupisella, John, St-Onge, Stéphane, Carrier, Marilyn, Cook, Erica M., Wang, Tao, Sum, Chi, Fernando, Gayani, Apgar, Kendra, Zhang, Rongan, Carson, Nancy, Snyder, Bradley J., Ryan, Carol S., Ma, Xiuying, Dierks, Elizabeth A., Little, Sean, Kick, Ellen K., Wurtz, Nicholas R., Bouvier, Michel, Héroux, Madeleine, Garcia, Ricardo A.

“…Formyl peptide receptor 2 (FPR2) plays an integral role in the transition of macrophages from a pro-inflammatory program to one that is pro-resolving…”
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11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice by García, Ricardo A, Search, Debra J, Lupisella, John A, Ostrowski, Jacek, Guan, Bo, Chen, Jian, Yang, Wen-Pin, Truong, Amy, He, Aiqing, Zhang, Rongan, Yan, Mujing, Hellings, Samuel E, Gargalovic, Peter S, Ryan, Carol S, Watson, Linda M, Langish, Robert A, Shipkova, Petia A, Carson, Nancy L, Taylor, Joseph R, Yang, Richard, Psaltis, George C, Harrity, Thomas W, Robl, Jeffrey A, Gordon, David A

“…Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme 11β-hydroxysteroid…”
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(3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic Acid (BMS-644950): A Rationally Designed Orally Efficacious 3-Hydroxy-3-methylglutaryl Coenzyme-A Reductase Inhibitor with Reduced Myotoxicity Potential by Ahmad, Saleem, Madsen, Cort S, Stein, Philip D, Janovitz, Evan, Huang, Christine, Ngu, Khehyong, Bisaha, Sharon, Kennedy, Lawrence J, Chen, Bang-Chi, Zhao, Rulin, Sitkoff, Doree, Monshizadegan, Hossain, Yin, Xiaohong, Ryan, Carol S, Zhang, Rongan, Giancarli, Mary, Bird, Eileen, Chang, Ming, Chen, Xing, Setters, Robert, Search, Debra, Zhuang, Shaobin, Nguyen-Tran, Van, Cuff, Carolyn A, Harrity, Thomas, Darienzo, Celia J, Li, Tong, Reeves, Richard A, Blanar, Michael A, Barrish, Joel C, Zahler, Robert, Robl, Jeffrey A

“…3-Hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR) inhibitors, more commonly known as statins, represent the gold standard in treating…”
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The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins by Madsen, Cort S, Janovitz, Evan, Zhang, Rongan, Nguyen-Tran, Van, Ryan, Carol S, Yin, Xiaohong, Monshizadegan, Hossain, Chang, Ming, D'Arienzo, Celia, Scheer, Susan, Setters, Robert, Search, Debra, Chen, Xing, Zhuang, Shaobin, Kunselman, Lori, Peters, Andrew, Harrity, Thomas, Apedo, Atsu, Huang, Christine, Cuff, Carolyn A, Kowala, Mark C, Blanar, Michael A, Sun, Chong-Qing, Robl, Jeffrey A, Stein, Philip D

“…Statins, because of their excellent efficacy and manageable safety profile, represent a key component in the current armamentarium for the treatment of…”
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Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50 by Ishikawa, H, Claudio, E, Dambach, D, Raventós-Suárez, C, Ryan, C, Bravo, R

“…The polypeptide (p)50 molecule, a subunit of nuclear factor (NF)-kappaB, is produced after proteolytic processing of the p105 precursor (NF-kappaB1). Although…”
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Novel dual action AT1 and ETA receptor antagonists reduce blood pressure in experimental hypertension by Kowala, Mark C, Murugesan, Natesan, Tellew, John, Carlson, Kenneth, Monshizadegan, Hossain, Ryan, Carol, Gu, Zhengxiang, Kane, Bridgette, Fadnis, Leena, Baska, Rose Ann, Beyer, Sophie, Arthur, Susan, Dickinson, Kenneth, Zhang, Donglu, Perrone, Mark, Ferrer, Pam, Giancarli, Mary, Baumann, Jergen, Bird, Eileen, Panchal, Balkrushna, Yang, Yifan, Trippodo, Nick, Barrish, Joel, Macor, John E

“…Angiotensin II and endothelin-1 activate their respective AT(1) and ET(A) receptors on vascular smooth muscle cells, producing vasoconstriction, and both…”
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De Novo Genome and Transcriptome Assembly of the Canadian Beaver ( Castor canadensis ) by Lok, Si, Paton, Tara A, Wang, Zhuozhi, Kaur, Gaganjot, Walker, Susan, Yuen, Ryan K C, Sung, Wilson W L, Whitney, Joseph, Buchanan, Janet A, Trost, Brett, Singh, Naina, Apresto, Beverly, Chen, Nan, Coole, Matthew, Dawson, Travis J, Ho, Karen, Hu, Zhizhou, Pullenayegum, Sanjeev, Samler, Kozue, Shipstone, Arun, Tsoi, Fiona, Wang, Ting, Pereira, Sergio L, Rostami, Pirooz, Ryan, Carol Ann, Tong, Amy Hin Yan, Ng, Karen, Sundaravadanam, Yogi, Simpson, Jared T, Lim, Burton K, Engstrom, Mark D, Dutton, Christopher J, Kerr, Kevin C R, Franke, Maria, Rapley, William, Wintle, Richard F, Scherer, Stephen W

“…The Canadian beaver ( ) is the largest indigenous rodent in North America. We report a draft annotated assembly of the beaver genome, the first for a large…”
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Resources for Increasing Physical Activity in Children and Youth by Ryan, Carol A., Beighle, Aaron

“…The number of children and youth who are overweight has reached epidemic proportions in the United States. According to the 2007-2008 National Health and…”
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Healing response to the clamshell device for closure of intracardiac defects in humans by Kreutzer, Jacqueline, Ryan, Carol A., Gauvreau, Kimberlee, Van Praagh, Richard, Anderson, James M., Jenkins, Kathy J.

“…The healing response to intracardiac devices in humans is largely unknown. During regulatory trials using the Clamshell device in over 800 patients, attempts…”
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Discovery of 4′-[(Imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/Angiotensin II receptor antagonists by Tellew, John E, Baska, Rose Ann F, Beyer, Sophie M, Carlson, Kenneth E, Cornelius, Lyndon A, Fadnis, Leena, Gu, Zhengxiang, Kunst, Bridgette L, Kowala, Mark C, Monshizadegan, Hossain, Murugesan, Natesan, Ryan, Carol S, Valentine, Maria T, Yang, Yifan, Macor, John E

“…A series of 4′-[(imidazol-1-yl)methyl]biphenylsulfonamides has potent antagonist activity against both angiotensin II AT 1 and endothelin ET A receptors. Such…”
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The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations by Villani, Anita, Davidson, Scott, Kanwar, Nisha, Lo, Winnie W, Li, Yisu, Cohen-Gogo, Sarah, Fuligni, Fabio, Edward, Lisa-Monique, Light, Nicholas, Layeghifard, Mehdi, Harripaul, Ricardo, Waldman, Larissa, Gallinger, Bailey, Comitani, Federico, Brunga, Ledia, Hayes, Reid, Anderson, Nathaniel D, Ramani, Arun K, Yuki, Kyoko E, Blay, Sasha, Johnstone, Brittney, Inglese, Cara, Hammad, Rawan, Goudie, Catherine, Shuen, Andrew, Wasserman, Jonathan D, Venier, Rosemarie E, Eliou, Marianne, Lorenti, Miranda, Ryan, Carol Ann, Braga, Michael, Gloven-Brown, Meagan, Han, Jianan, Montero, Maria, Spatare, Famida, Whitlock, James A, Scherer, Stephen W, Chun, Kathy, Somerville, Martin J, Hawkins, Cynthia, Abdelhaleem, Mohamed, Ramaswamy, Vijay, Somers, Gino R, Kyriakopoulou, Lianna, Hitzler, Johann, Shago, Mary, Morgenstern, Daniel A, Tabori, Uri, Meyn, Stephen, Irwin, Meredith S, Malkin, David, Shlien, Adam

“…We conducted integrative somatic-germline analyses by deeply sequencing 864 cancer-associated genes, complete genomes and transcriptomes for 300 mostly…”
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Snack and Relax: A Strategy to Address Nurses’ Professional Quality of Life by Markwell, Perpetua, Polivka, Barbara J., Morris, Katrina, Ryan, Carol, Taylor, Annetra

“…Purpose and Design: Snack and Relax® (S&R), a program providing healthy snacks and holistic relaxation modalities to hospital employees, was evaluated for…”
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Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL‑C Increase In Vivo by Tora, George, Kim, Soong-Hoon, Pi, Zulan, Johnson, James A, Jiang, Ji, Phillips, Monique, Lloyd, John, Abell, Lynn M, Lu, Hao, Locke, Gregory, Adam, Leonard P, Taylor, David S, Yin, Xiaohong, Behnia, Kamelia, Zhao, Lei, Yang, Richard, Basso, Michael, Caporuscio, Christian, Chen, Alice Ye, Liu, Eddie, Kirshgessner, Todd, Onorato, Joelle M, Ryan, Carol, Traeger, Sarah C, Gordon, David, Wexler, Ruth R, Finlay, Heather J

“…Endothelial lipase (EL) hydrolyzes phospholipids in high-density lipoprotein (HDL) resulting in reduction in plasma HDL levels. Studies with murine transgenic,…”
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Professional Development and Training for Faculty Advisers by Ryan, Carol C

“…Faculty need more general institutional information and training if they are to perform effectively as academic advisors. Three key elements in their…”
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