Search Results - "Ryan, Caila"

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation by Douillet, Delphine, Sze, Christie C., Ryan, Caila, Piunti, Andrea, Shah, Avani P., Ugarenko, Michal, Marshall, Stacy A., Rendleman, Emily J., Zha, Didi, Helmin, Kathryn A., Zhao, Zibo, Cao, Kaixiang, Morgan, Marc A., Singer, Benjamin D., Bartom, Elizabeth T., Smith, Edwin R., Shilatifard, Ali

“…The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates…”
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A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells by Cenik, Bercin K, Sze, Christie C, Ryan, Caila A, Das, Siddhartha, Cao, Kaixiang, Douillet, Delphine, Rendleman, Emily J, Zha, Didi, Khan, Nabiha Haleema, Bartom, Elizabeth, Shilatifard, Ali

“…Embryonic stem cells (ESCs) are defined by their ability to self-renew and the potential to differentiate into all tissues of the developing organism. We…”
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CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism by Piunti, Andrea, Smith, Edwin R, Morgan, Marc A J, Ugarenko, Michal, Khaltyan, Natalia, Helmin, Kathryn A, Ryan, Caila A, Murray, David C, Rickels, Ryan A, Yilmaz, Bahar D, Rendleman, Emily J, Savas, Jeffrey N, Singer, Benjamin D, Bulun, Serdar E, Shilatifard, Ali

“…Using biochemical characterization of fusion proteins associated with endometrial stromal sarcoma, we identified JAZF1 as a new subunit of the NuA4…”
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Coordinated regulation of cellular identity-associated H3K4me3 breadth by the COMPASS family by Sze, Christie C, Ozark, Patrick A, Cao, Kaixiang, Ugarenko, Michal, Das, Siddhartha, Wang, Lu, Marshall, Stacy A, Rendleman, Emily J, Ryan, Caila A, Zha, Didi, Douillet, Delphine, Chen, Fei Xavier, Shilatifard, Ali

“…Set1A and Set1B, two members of the COMPASS family of methyltransferases that methylate the histone H3 lysine 4 (H3K4) residue, have been accredited as primary…”
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TET2 coactivates gene expression through demethylation of enhancers by Wang, Lu, Ozark, Patrick A, Smith, Edwin R, Zhao, Zibo, Marshall, Stacy A, Rendleman, Emily J, Piunti, Andrea, Ryan, Caila, Whelan, Anna L, Helmin, Kathryn A, Morgan, Marc Alard, Zou, Lihua, Singer, Benjamin D, Shilatifard, Ali

“…The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is…”
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Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia by Wang, Lu, Birch, Noah Warren, Zhao, Zibo, Nestler, Carson Meredith, Kazmer, Alexander, Shilati, Anthony, Blake, Alisha, Ozark, Patrick Alexander, Rendleman, Emily Jane, Zha, Didi, Ryan, Caila Ann, Morgan, Marc Alard Jonathan, Shilatifard, Ali

“…Mutations of ASXL1, encoding a component of the BAP1 histone H2A deubiquitinase complex, occur in human myeloid neoplasms and are uniformly associated with…”
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The WD40 domain of FBXW7 is a poly(ADP-ribose)-binding domain that mediates the early DNA damage response by Zhang, Qiang, Mady, Ahmed S A, Ma, Yuanyuan, Ryan, Caila, Lawrence, Theodore S, Nikolovska-Coleska, Zaneta, Sun, Yi, Morgan, Meredith A

“…Abstract FBXW7, a classic tumor suppressor, is a substrate recognition subunit of the Skp1-cullin-F-box (SCF) ubiquitin ligase that targets oncoproteins for…”
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Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Regardless of TP53 Mutational Status Through Induction of Replication Stress by Cuneo, Kyle C., MD, Morgan, Meredith A., PhD, Davis, Mary A., PhD, Parcels, Leslie A., PhD, Parcels, Joshua, BS, Karnak, David, PhD, Ryan, Caila, Liu, Na, BS, Maybaum, Jonathan, PhD, Lawrence, Theodore S., MD, PhD

“…Purpose Wee1 kinase inhibitors are effective radiosensitizers in cells lacking a G1 checkpoint. In this study we examined the potential effect of Wee1 kinase…”
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β-Catenin/Tcf7l2-dependent transcriptional regulation of GLUT1 gene expression by Zic family proteins in colon cancer by Zhao, Zibo, Wang, Lu, Bartom, Elizabeth, Marshall, Stacy, Rendleman, Emily, Ryan, Caila, Shilati, Anthony, Savas, Jeffrey, Chandel, Navdeep, Shilatifard, Ali

“…The zinc finger of the cerebellum (ZIC) proteins has been implicated to function in normal tissue development. Recent studies have described the critical…”
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Abstract B46: CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb Repressive complex 2 via a H3K27M-like mechanism by Piunti, Andrea, Smith, Edwin, Morgan, Marc, Ugarenko, Michal, Khaltyan, Natalia, Helmin, Kathryn, Ryan, Caila, Murray, David, Rickels, Ryan, Yilmaz, Bahar, Rendleman, Emily, Savas, Jeffrey, Singer, Benjamin, Bulun, Serdar, Shilatifard, Ali

“…Abstract Dysregulation of Polycomb Repressive Complex 2 (PRC2) function is a common feature of many cancer types, including both solid and hematologic…”
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