Search Results - "Ruzzini, Antonio"

Gene Flow and Molecular Innovation in Bacteria by Ruzzini, Antonio C., Clardy, Jon

“…The small molecules produced by environmental bacteria have been mainstays of both chemical and biological research for decades, and some have led to important…”
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Tryptorubin A: A Polycyclic Peptide from a Fungus-Derived Streptomycete by Wyche, Thomas P, Ruzzini, Antonio C, Schwab, Laura, Currie, Cameron R, Clardy, Jon

“…Fungus-growing ants engage in complex symbiotic relationships with their fungal crop, specialized fungal pathogens, and bacteria that provide chemical…”
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Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants by Sit, Clarissa S., Ruzzini, Antonio C., Van Arnam, Ethan B., Ramadhar, Timothy R., Currie, Cameron R., Clardy, Jon

“…Small molecules produced by Actinobacteria have played a prominent role in both drug discovery and organic chemistry. As part of a larger study of the…”
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Comparison of individual hive and apiary-level sample types for spores of Paenibacillus larvae in Saskatchewan honey bee operations by Zabrodski, Michael W, DeBruyne, Jessica E, Wilson, Geoff, Moshynskyy, Igor, Sharafi, Mohsen, Wood, Sarah C, Kozii, Ivanna V, Thebeau, Jenna, Klein, Colby D, Medici de Mattos, Igor, Sobchishin, LaRhonda, Epp, Tasha, Ruzzini, Antonio C, Simko, Elemir

“…Three commercial honey bee operations in Saskatchewan, Canada, with outbreaks of American foulbrood (AFB) and recent or ongoing metaphylactic antibiotic use…”
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Pyrazines from bacteria and ants: convergent chemistry within an ecological niche by Silva-Junior, Eduardo A., Ruzzini, Antonio C., Paludo, Camila R., Nascimento, Fabio S., Currie, Cameron R., Clardy, Jon, Pupo, Mônica T.

“…Ants use pheromones to coordinate their communal activity. Volatile pyrazines, for instance, mediate food resource gathering and alarm behaviors in different…”
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Selvamicin, an atypical antifungal polyene from two alternative genomic contexts by Van Arnam, Ethan B., Ruzzini, Antonio C., Sit, Clarissa S., Horn, Heidi, Pinto-Tomás, Adrián A., Currie, Cameron R., Clardy, Jon

“…The bacteria harbored by fungus-growing ants produce a variety of small molecules that help maintain a complex multilateral symbiosis. In a survey of…”
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Cell-Penetrating Antimicrobial Peptides Derived from an Atypical Staphylococcal δ-Toxin by Deeyagahage, Kathyana, Ruzzini, Antonio

“…Revisiting underutilized classes of antibiotics is a pragmatic approach to the identification of alternative therapies for antimicrobial-resistant pathogens…”
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A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense by Van Arnam, Ethan B, Ruzzini, Antonio C, Sit, Clarissa S, Currie, Cameron R, Clardy, Jon

“…Bacterial symbionts of fungus-growing ants occupy a highly specialized ecological niche and face the constant existential threat of displacement by another…”
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Evaluating approved and alternative treatments against an oxytetracycline-resistant bacterium responsible for European foulbrood disease in honey bees by Masood, Fatima, Thebeau, Jenna M., Cloet, Allyssa, Kozii, Ivanna V., Zabrodski, Michael W., Biganski, Sarah, Liang, Jenny, Marta Guarna, M., Simko, Elemir, Ruzzini, Antonio, Wood, Sarah C.

“…European foulbrood (EFB) is a disease of honey bee larvae caused by Melissococcus plutonius . In North America, oxytetracycline (OTC) is approved to combat EFB…”
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Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides by Wyche, Thomas P, Ruzzini, Antonio C, Beemelmanns, Christine, Kim, Ki Hyun, Klassen, Jonathan L, Cao, Shugeng, Poulsen, Michael, Bugni, Tim S, Currie, Cameron R, Clardy, Jon

“…Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The…”
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Insight into antimicrobial resistance at a new beef cattle feedlot in western Canada by Kos, Daniel, Schreiner, Brittany, Thiessen, Stuart, McAllister, Tim, Jelinski, Murray, Ruzzini, Antonio

“…A better understanding of how environmental reservoirs of ARGs in the feedlot relate to those found in animal pathogens will help inform and improve disease…”
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Establishment of apiary-level risk of American foulbrood through the detection of Paenibacillus larvae spores in pooled, extracted honey in Saskatchewan by Zabrodski, Michael W., Epp, Tasha, Wilson, Geoff, Moshynskyy, Igor, Sharafi, Mohsen, Reitsma, Lara, Castano Ospina, Mateo, DeBruyne, Jessica E., Wentzell, Alexandra, Wood, Sarah C., Kozii, Ivanna V., Klein, Colby D., Thebeau, Jenna, Sobchishin, LaRhonda, Ruzzini, Antonio C., Simko, Elemir

“…Paenibacillus larvae , the causative agent of American foulbrood (AFB), produces spores that may be detectable within honey. We analyzed the spore content of…”
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Metabolites Involved in Immune Evasion by Batrachochytrium dendrobatidis Include the Polyamine Spermidine by Rollins-Smith, Louise A, Ruzzini, Antonio C, Fites, J Scott, Reinert, Laura K, Hall, Emily M, Joosse, Bryan A, Ravikumar, Vishvaas I, Huebner, Megan I, Aka, Audrey, Kehs, Miles H, Gillard, Bria M, Doe, Emily, Tasca, Julia A, Umile, Thomas P, Clardy, Jon, Minbiole, Kevin P C

“…Amphibians have been declining around the world for more than four decades. One recognized driver of these declines is the chytrid fungus , which causes the…”
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A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules by Kulig, Justyna K., Spandolf, Claudia, Hyde, Ralph, Ruzzini, Antonio C., Eltis, Lindsay D., Grönberg, Gunnar, Hayes, Martin A., Grogan, Gideon

“…[Display omitted] The actinomycete Rhodococcus jostii RHA1 contains a multitude of oxygenase enzymes, consonant with its remarkable activities in the…”
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Investigation of Macrolide Resistance Genotypes in Mycoplasma bovis Isolates from Canadian Feedlot Cattle by Kinnear, Andrea, McAllister, Tim A., Zaheer, Rahat, Waldner, Matthew, Ruzzini, Antonio C., Andrés-Lasheras, Sara, Parker, Sarah, Hill, Janet E., Jelinski, Murray D.

“…Mycoplasma bovis is associated with bovine respiratory disease (BRD) and chronic pneumonia and polyarthritis syndrome (CPPS) in feedlot cattle. No efficacious…”
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The Catalytic Serine of meta-Cleavage Product Hydrolases Is Activated Differently for C–O Bond Cleavage Than for C–C Bond Cleavage by Ruzzini, Antonio C, Horsman, Geoff P, Eltis, Lindsay D

“…meta-Cleavage product (MCP) hydrolases catalyze C–C bond fission in the aerobic catabolism of aromatic compounds by bacteria. These enzymes utilize a…”
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Identification of an Acyl-Enzyme Intermediate in a meta-Cleavage Product Hydrolase Reveals the Versatility of the Catalytic Triad by Ruzzini, Antonio C, Ghosh, Subhangi, Horsman, Geoff P, Foster, Leonard J, Bolin, Jeffrey T, Eltis, Lindsay D

“…Meta-cleavage product (MCP) hydrolases are members of the α/β-hydrolase superfamily that utilize a Ser-His-Asp triad to catalyze the hydrolysis of a C–C bond…”
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The Lid Domain of the MCP Hydrolase DxnB2 Contributes to the Reactivity toward Recalcitrant PCB Metabolites by Ruzzini, Antonio C, Bhowmik, Shiva, Yam, Katherine C, Ghosh, Subhangi, Bolin, Jeffrey T, Eltis, Lindsay D

“…DxnB2 and BphD are meta-cleavage product (MCP) hydrolases that catalyze C–C bond hydrolysis of the biphenyl metabolite 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic…”
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Are fungicides a driver of European foulbrood disease in honey bee colonies pollinating blueberries? by Thebeau, Jenna M., Cloet, Allyssa, Liebe, Dana, Masood, Fatima, Kozii, Ivanna V., Klein, Colby D., Zabrodski, Michael W., Biganski, Sarah, Moshynskyy, Igor, Sobchishin, Larhonda, Wilson, Geoff, Guarna, Maria Marta, Gerbrandt, Eric M., Ruzzini, Antonio, Simko, Elemir, Wood, Sarah C.

“…IntroductionBlueberry producers in Canada depend heavily on pollination services provided by honey bees (Apis mellifera L.). Anecdotal reports indicate an…”
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A Substrate-Assisted Mechanism of Nucleophile Activation in a Ser–His–Asp Containing C–C Bond Hydrolase by Ruzzini, Antonio C, Bhowmik, Shiva, Ghosh, Subhangi, Yam, Katherine C, Bolin, Jeffrey T, Eltis, Lindsay D

“…The meta-cleavage product (MCP) hydrolases utilize a Ser–His–Asp triad to hydrolyze a carbon–carbon bond. Hydrolysis of the MCP substrate has been proposed to…”
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