Search Results - "Ruzo, Albert"

Morphogen and community effects determine cell fates in response to BMP4 signaling in human embryonic stem cells by Nemashkalo, Anastasiia, Ruzo, Albert, Heemskerk, Idse, Warmflash, Aryeh

“…Paracrine signals maintain developmental states and create cell fate patterns and influence differentiation outcomes in human embryonic stem cells (hESCs)…”
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A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization by Etoc, Fred, Metzger, Jakob, Ruzo, Albert, Kirst, Christoph, Yoney, Anna, Ozair, M. Zeeshan, Brivanlou, Ali H., Siggia, Eric D.

“…The earliest aspects of human embryogenesis remain mysterious. To model patterning events in the human embryo, we used colonies of human embryonic stem cells…”
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High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries by Mullokandov, Gavriel, Baccarini, Alessia, Ruzo, Albert, Jayaprakash, Anitha D, Tung, Navpreet, Israelow, Benjamin, Evans, Matthew J, Sachidanandam, Ravi, Brown, Brian D

“…Two large-scale resources for studying microRNA function are presented: one is a library of fluorescent sensors with a corresponding assay for global profiling…”
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WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids by Yoney, Anna, Etoc, Fred, Ruzo, Albert, Carroll, Thomas, Metzger, Jakob J, Martyn, Iain, Li, Shu, Kirst, Christoph, Siggia, Eric D, Brivanlou, Ali H

“…Self-organization of discrete fates in human gastruloids is mediated by a hierarchy of signaling pathways. How these pathways are integrated in time, and…”
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Self-organization of human embryonic stem cells on micropatterns by Deglincerti, Alessia, Etoc, Fred, Guerra, M Cecilia, Martyn, Iain, Metzger, Jakob, Ruzo, Albert, Simunovic, Mijo, Yoney, Anna, Brivanlou, Ali H, Siggia, Eric, Warmflash, Aryeh

“…This protocol describes how to differentiate and image human embryonic stem cells on micropatterned colonies to create radially organized domains of the germ…”
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BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups by Berres, Marie-Luise, Lim, Karen Phaik Har, Peters, Tricia, Price, Jeremy, Takizawa, Hitoshi, Salmon, Hélène, Idoyaga, Juliana, Ruzo, Albert, Lupo, Philip J, Hicks, M John, Shih, Albert, Simko, Stephen J, Abhyankar, Harshal, Chakraborty, Rikhia, Leboeuf, Marylene, Beltrão, Monique, Lira, Sérgio A, Heym, Kenneth M, Bigley, Venetia, Collin, Matthew, Manz, Markus G, McClain, Kenneth, Merad, Miriam, Allen, Carl E

“…Langerhans cell histiocytosis (LCH) is a clonal disorder with elusive etiology, characterized by the accumulation of CD207(+) dendritic cells (DCs) in…”
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The miR-126–VEGFR2 axis controls the innate response to pathogen-associated nucleic acids by Agudo, Judith, Ruzo, Albert, Tung, Navpreet, Salmon, Hélène, Leboeuf, Marylène, Hashimoto, Daigo, Becker, Christian, Garrett-Sinha, Lee-Ann, Baccarini, Alessia, Merad, Miriam, Brown, Brian D

“…Plasmacytoid dendritic cells produce copious amounts of type I interferon in response to viral infection. Brown and colleagues show that the homeostasis and…”
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Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy by Haurigot, Virginia, Marcó, Sara, Ribera, Albert, Garcia, Miguel, Ruzo, Albert, Villacampa, Pilar, Ayuso, Eduard, Añor, Sònia, Andaluz, Anna, Pineda, Mercedes, García-Fructuoso, Gemma, Molas, Maria, Maggioni, Luca, Muñoz, Sergio, Motas, Sandra, Ruberte, Jesús, Mingozzi, Federico, Pumarola, Martí, Bosch, Fatima

“…For most lysosomal storage diseases (LSDs) affecting the CNS, there is currently no cure. The BBB, which limits the bioavailability of drugs administered…”
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Chromosomal instability during neurogenesis in Huntington's disease by Ruzo, Albert, Croft, Gist F, Metzger, Jakob J, Galgoczi, Szilvia, Gerber, Lauren J, Pellegrini, Cecilia, Wang, Jr, Hanbin, Fenner, Maria, Tse, Stephanie, Marks, Adam, Nchako, Corbyn, Brivanlou, Ali H

“…Huntington's disease (HD) is a fatal neurodegenerative disease caused by expansion of CAG repeats in the Huntingtin gene ( ). Neither its pathogenic mechanisms…”
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Correction of pathological accumulation of glycosaminoglycans in central nervous system and peripheral tissues of MPSIIIA mice through systemic AAV9 gene transfer by Ruzo, Albert, Marcó, Sara, García, Miquel, Villacampa, Pilar, Ribera, Albert, Ayuso, Eduard, Maggioni, Lucca, Mingozzi, Federico, Haurigot, Virginia, Bosch, Fatima

“…Mucopolysaccharidosis type IIIA (MPSIIIA) is a rare lysosomal storage disorder caused by mutations in the sulfamidase gene. Accumulation of glycosaminoglycan…”
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Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles by Nielsen, Ian Helstrup, Rovsing, Anne Bruun, Janns, Jacob Hørlück, Thomsen, Emil Aagaard, Ruzo, Albert, Bøggild, Andreas, Nedergaard, Frederikke, Møller, Charlotte Thornild, Boesen, Thomas, Degn, Søren Egedal, Shah, Jagesh V., Mikkelsen, Jacob Giehm

“…To fully utilize the potential of CRISPR-Cas9-mediated genome editing, time-restricted and targeted delivery is crucial. By modulating the pseudotype of…”
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Discovery of novel isoforms of huntingtin reveals a new hominid-specific exon by Ruzo, Albert, Ismailoglu, Ismail, Popowski, Melissa, Haremaki, Tomomi, Croft, Gist F, Deglincerti, Alessia, Brivanlou, Ali H

“…Huntington's disease (HD) is a devastating neurological disorder that is caused by an expansion of the poly-Q tract in exon 1 of the Huntingtin gene (HTT). HTT…”
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Phosphofructo-1-kinase deficiency leads to a severe cardiac and hematological disorder in addition to skeletal muscle glycogenosis by García, Miguel, Pujol, Anna, Ruzo, Albert, Riu, Efrén, Ruberte, Jesús, Arbós, Anna, Serafín, Anna, Albella, Beatriz, Felíu, Juan Emilio, Bosch, Fátima

“…Mutations in the gene for muscle phosphofructo-1-kinase (PFKM), a key regulatory enzyme of glycolysis, cause Type VII glycogen storage disease (GSDVII)…”
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GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions by Agudo, Judith, Ruzo, Albert, Park, Eun Sook, Sweeney, Robert, Kana, Veronika, Wu, Meng, Zhao, Yong, Egli, Dieter, Merad, Miriam, Brown, Brian D

“…T cells specific for GFP allow depletion of specific cell types in mice. There are numerous cell types with scarcely understood functions, whose interactions…”
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A 3D model of a human epiblast reveals BMP4-driven symmetry breaking by Simunovic, Mijo, Metzger, Jakob J., Etoc, Fred, Yoney, Anna, Ruzo, Albert, Martyn, Iain, Croft, Gist, You, Dong Shin, Brivanlou, Ali H., Siggia, Eric D.

“…Breaking the anterior–posterior symmetry in mammals occurs at gastrulation. Much of the signalling network underlying this process has been elucidated in the…”
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Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche by Baldominos, Pilar, Barbera-Mourelle, Alex, Barreiro, Olga, Huang, Yu, Wight, Andrew, Cho, Jae-Won, Zhao, Xi, Estivill, Guillem, Adam, Isam, Sanchez, Xavier, McCarthy, Shannon, Schaller, Julien, Khan, Zara, Ruzo, Albert, Pastorello, Ricardo, Richardson, Edward T., Dillon, Deborah, Montero-Llopis, Paula, Barroso-Sousa, Romualdo, Forman, Juliet, Shukla, Sachet A., Tolaney, Sara M., Mittendorf, Elizabeth A., von Andrian, Ulrich H., Wucherpfennig, Kai W., Hemberg, Martin, Agudo, Judith

“…Immunotherapy is a promising treatment for triple-negative breast cancer (TNBC), but patients relapse, highlighting the need to understand the mechanisms of…”
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hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate by Ozair, M. Zeeshan, Kirst, Christoph, van den Berg, Bastiaan L., Ruzo, Albert, Rito, Tiago, Brivanlou, Ali H.

“…Cortical deep projection neurons (DPNs) are implicated in neurodevelopmental disorders. Although recent findings emphasize post-mitotic programs in projection…”
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At Last: Gene Editing in Human Embryos to Understand Human Development by Ruzo, Albert, Brivanlou, Ali H.

“…Our understanding of early human development is typically based on inference from animal models, which may not fully recapitulate human embryonic features. As…”
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Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects by Galgoczi, Szilvia, Ruzo, Albert, Markopoulos, Christian, Yoney, Anna, Phan-Everson, Tien, Li, Shu, Haremaki, Tomomi, Metzger, Jakob J., Etoc, Fred, Brivanlou, Ali H.

“…ABSTRACT Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG repeats in the huntingtin gene (HTT). Although HD…”
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Efficient and Specific In Vivo Genetic Engineering of Human Hematopoietic Stem Progenitor Cells without Selective Conditioning by Botchkarev, Vladimir V, Harrington, Sean, Justen, Alexander, Kimber, Casey, Kapuria, Anjali, Xu, Yuanxin, Haugh, Kelsey, Ankala, Ramya, Kipniss, Nathan, de Jesus, Rowena, Adewale, Funmi, Daniels, Kathy, Crocker, Samantha, Liang, Anna, Joyce, Shannon, Smith, Derek, Wong, Athena, Berlfein, Valeria, Amatya, Shirisha, Cruite, Patricia, Usmani, Shariq, Ruzo, Albert, Ferland, Benjamin, Chandra, Sundeep, Stoppato, Matteo, Trudeau, Kyle, Rebar, Edward, Shah, Jagesh, Biasco, Luca

“…Achieving in vivo genetic engineering of hematopoietic stem progenitor cells (HSPC) has the potential to transform treatment for hematological disorders. An…”
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