Search Results - "Rutledge, Peter J."

Discovery of microbial natural products by activation of silent biosynthetic gene clusters by Rutledge, Peter J., Challis, Gregory L.

“…Key Points Microorganisms produce an array of specialized metabolites with a wide range of biological activities and potential applications, such as…”
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Recently Discovered Secondary Metabolites from Streptomyces Species by Lacey, Heather J, Rutledge, Peter J

“…The genus has been a rich source of bioactive natural products, medicinal chemicals, and novel drug leads for three-quarters of a century. Yet studies suggest…”
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Metal complexes as a promising source for new antibiotics by Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G, Baker, Murray, Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher, Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed M, Massi, Massimiliano, Moat, John, Mohamed, Heba A, Renfrew, Anna K, Rutledge, Peter J, Sadler, Peter J, Todd, Matthew H, Willans, Charlotte E, Wilson, Justin J, Cooper, Matthew A, Blaskovich, Mark A. T

“…There is a dire need for new antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug…”
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Isopenicillin N Synthase: Crystallographic Studies by Chapman, Nicole C., Rutledge, Peter J.

“…Isopenicillin N synthase (IPNS) is a non‐heme iron oxidase (NHIO) that catalyses the cyclisation of tripeptide δ‐(l‐α‐aminoadipoyl)‐l‐cysteinyl‐d‐valine (ACV)…”
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Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing by Wong, Joseph K-H, Todd, Matthew H, Rutledge, Peter J

“…Small-molecule fluorescent probes play a myriad of important roles in chemical sensing. Many such systems incorporating a receptor component designed to…”
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Antitubercular Bis-Substituted Cyclam Derivatives: Structure–Activity Relationships and in Vivo Studies by Spain, Malcolm, Wong, Joseph K.-H, Nagalingam, Gayathri, Batten, James M, Hortle, Elinor, Oehlers, Stefan H, Jiang, Xiao Fan, Murage, Hasini E, Orford, Jack T, Crisologo, Patrick, Triccas, James A, Rutledge, Peter J, Todd, Matthew H

“…We recently reported the discovery of nontoxic cyclam-derived compounds that are active against drug-resistant Mycobacterium tuberculosis. In this paper we…”
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Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3 by Lacey, Heather J., Chen, Rachel, Vuong, Daniel, Fisher, Mark F., Lacey, Ernest, Rutledge, Peter J., Piggott, Andrew M.

“…Amycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cultivation of MST-135876 on a range of…”
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Conglobatins B–E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin by Lacey, Heather J., Booth, Thomas J., Vuong, Daniel, Rutledge, Peter J., Lacey, Ernest, Chooi, Yit-Heng, Piggott, Andrew M.

“…Chemical investigation of a previously unreported indigenous Australian Streptomyces strain MST-91080 has identified six novel analogues related to the…”
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Yeppoonic acids A – D: 1,2,4-trisubstituted arene carboxylic acid co-metabolites of conglobatin from an Australian Streptomyces sp by Lacey, Heather, Chen, Rachel, Vuong, Daniel, Cowled, Michael S., Lacey, Ernest, Rutledge, Peter J., Piggott, Andrew M.

“…Streptomyces sp. MST-91080 was isolated from a soil sample collected in Queensland, Australia. From this strain, yeppoonic acids A – D were purified and…”
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Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis by Lacey, Heather J, Gilchrist, Cameron L M, Crombie, Andrew, Kalaitzis, John A, Vuong, Daniel, Rutledge, Peter J, Turner, Peter, Pitt, John I, Lacey, Ernest, Chooi, Yit-Heng, Piggott, Andrew M

“…Chemical investigation of an undescribed Australian fungus, Aspergillus nanangensis , led to the identification of the nanangenines – a family of seven new and…”
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Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non‐Heme Iron Oxidases by McNeill, Luke A., Brown, Toby J. N., Sami, Malkit, Clifton, Ian J., Burzlaff, Nicolai I., Claridge, Timothy D. W., Adlington, Robert M., Baldwin, Jack E., Rutledge, Peter J., Schofield, Christopher J.

“…Isopenicillin N synthase (IPNS) catalyses the four‐electron oxidation of a tripeptide, l‐δ‐(α‐aminoadipoyl)‐l‐cysteinyl‐d‐valine (ACV), to give isopenicillin N…”
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Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids by Yu, Mingfeng, Wong, Joseph K-H, Tang, Cyril, Turner, Peter, Todd, Matthew H, Rutledge, Peter J

“…The effective and efficient removal of the BF2 moiety from F-BODIPY derivatives has been achieved using two common Brønsted acids; treatment with…”
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Investigating the oxidation of alkenes by non-heme iron enzyme mimics by Barry, Sarah M, Mueller-Bunz, Helge, Rutledge, Peter J

“…Iron is emerging as a key player in the search for efficient and environmentally benign methods for the functionalisation of C-H bonds. Non-heme iron enzymes…”
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Early warning smartphone diagnostics for water security and analysis using real-time pH mapping by Hossain, Md. Arafat, Canning, John, Ast, Sandra, Rutledge, Peter J., Jamalipour, Abbas

“…Early detection of environmental disruption, unintentional or otherwise, is increasingly desired to ensure hazard minimization in many settings. Here, using a…”
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Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates by Yu, Mingfeng, Ast, Sandra, Yu, Qun, Lo, Anthony T S, Flehr, Roman, Todd, Matthew H, Rutledge, Peter J

“…Ligands incorporating a tetraazamacrocycle receptor, a 'click'-derived triazole and a 1,8-naphthalimide fluorophore have proven utility as probes for metal…”
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A direct method for the N -tetraalkylation of azamacrocycles by Counsell, Andrew J, Jones, Angus T, Todd, Matthew H, Rutledge, Peter J

“…An efficient protocol for the direct synthesis of -tetraalkylated derivatives of the azamacrocycles cyclam and cyclen has been developed, using a partially…”
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Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid by Byrne, Cillian, Houlihan, Kate M, Devi, Prarthana, Jensen, Paul, Rutledge, Peter J

“…Nitrile hydratase (NHase, EC 4.2.1.84) is a metalloenzyme which catalyses the conversion of nitriles to amides. The high efficiency and broad substrate range…”
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Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI) by Manos-Turvey, Alexandra, Bulloch, Esther M. M., Rutledge, Peter J., Baker, Edward N., Lott, J. Shaun, Payne, Richard J.

“…Mycobacterium tuberculosis salicylate synthase (MbtI), a member of the chorismate‐utilizing enzyme family, catalyses the first committed step in the…”
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Iron complexes of tetramine ligands catalyse allylic hydroxyamination via a nitroso-ene mechanism by Porter, David, Poon, Belinda M-L, Rutledge, Peter J

“…Iron(II) complexes of the tetradentate amines tris(2-pyridylmethyl)amine (TPA) and N,N'-bis(2-pyridylmethyl)-N,N'-dimethylethane-1,2-diamine (BPMEN) are…”
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Synthesis and Evaluation of 1,8‐Disubstituted‐Cyclam/Naphthalimide Conjugates as Probes for Metal Ions by Wong, Joseph K.‐H., Ast, Sandra, Yu, Mingfeng, Flehr, Roman, Counsell, Andrew J., Turner, Peter, Crisologo, Patrick, Todd, Matthew H., Rutledge, Peter J.

“…Fluorescent molecular probes for metal ions have a raft of potential applications in chemistry and biomedicine. We report the synthesis and photophysical…”
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