Search Results - "Rutkowski, Joseph M"

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk by Stern, Jennifer H., Rutkowski, Joseph M., Scherer, Philipp E.

“…Metabolism research has made tremendous progress over the last several decades in establishing the adipocyte as a central rheostat in the regulation of…”
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The cell biology of fat expansion by Rutkowski, Joseph M, Stern, Jennifer H, Scherer, Philipp E

“…Adipose tissue is a complex, multicellular organ that profoundly influences the function of nearly all other organ systems through its diverse metabolite and…”
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An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State by Crewe, Clair, Joffin, Nolwenn, Rutkowski, Joseph M., Kim, Min, Zhang, Fang, Towler, Dwight A., Gordillo, Ruth, Scherer, Philipp E.

“…We have uncovered the existence of extracellular vesicle (EV)-mediated signaling between cell types within the adipose tissue (AT) proper. This phenomenon…”
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VEGFR-3 signaling in macrophages: friend or foe in disease? by Kannan, Saranya, Rutkowski, Joseph M

“…Lymphatic vessels have been increasingly appreciated in the context of immunology not only as passive conduits for immune and cancer cell transport but also as…”
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Lymphangiogenesis: fuel, smoke, or extinguisher of inflammation’s fire? by Abouelkheir, Gabriella R, Upchurch, Bradley D, Rutkowski, Joseph M

“…Lymphangiogenesis is a recognized hallmark of inflammatory processes in tissues and organs as diverse as the skin, heart, bowel, and airways. In clinical and…”
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Mechanisms of obesity and related pathologies: The macro‐ and microcirculation of adipose tissue by Rutkowski, Joseph M., Davis, Kathryn E., Scherer, Philipp E.

“…Adipose tissue is an endocrine organ made up of adipocytes, various stromal cells, resident and infiltrating immune cells, and an extensive endothelial…”
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Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen by Gautron, Laurent, Rutkowski, Joseph M., Burton, Michael D., Wei, Wei, Wan, Yihong, Elmquist, Joel K.

“…ABSTRACT Accumulating evidence demonstrates that acetylcholine can directly modulate immune function in peripheral tissues including the spleen and…”
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Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity by Chakraborty, Adri, Barajas, Sheridan, Lammoglia, Gabriela M., Reyna, Andrea J., Morley, Thomas S., Johnson, Joshua A., Scherer, Philipp E., Rutkowski, Joseph M.

“…Obese adipose tissue expansion is an inflammatory process that results in dysregulated lipolysis, increased circulating lipids, ectopic lipid deposition, and…”
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A driving force for change: interstitial flow as a morphoregulator by Rutkowski, Joseph M, Swartz, Melody A

“…Dynamic stresses that are present in all living tissues drive small fluid flows, called interstitial flows, through the extracellular matrix. Interstitial flow…”
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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin by Scherer, Philipp E, Holland, William L, Miller, Russell A, Wang, Zhao V, Sun, Kai, Barth, Brian M, Bui, Hai H, Davis, Kathryn E, Bikman, Benjamin T, Halberg, Nils, Rutkowski, Joseph M, Wade, Mark R, Tenorio, Vincent M, Kuo, Ming-Shang, Brozinick, Joseph T, Zhang, Bei B, Birnbaum, Morris J, Summers, Scott A

“…The protein hormone adiponectin is known to have many beneficial systemic effects, including promoting cell survival, anti-inflammation and insulin…”
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Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and Fibrosis by Duhon, Bailey H, Phan, Thien T, Taylor, Shannon L, Crescenzi, Rachelle L, Rutkowski, Joseph M

“…Lymphedema and lipedema are complex diseases. While the external presentation of swollen legs in lower-extremity lymphedema and lipedema appear similar,…”
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Immune cell trafficking, lymphatics and hypertension by Balasubbramanian, Dakshnapriya, Lopez Gelston, Catalina A, Rutkowski, Joseph M, Mitchell, Brett M

“…Activated immune cell infiltration into organs contributes to the development and maintenance of hypertension. Studies targeting specific immune cell…”
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Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium by Miteva, Dimana O, Rutkowski, Joseph M, Dixon, J Brandon, Kilarski, Witold, Shields, Jacqueline D, Swartz, Melody A

“…RATIONALE:Lymphatic transport of peripheral interstitial fluid and dendritic cells (DCs) is important for both adaptive immunity and maintenance of tolerance…”
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Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice by Lopez Gelston, Catalina A, Balasubbramanian, Dakshnapriya, Abouelkheir, Gabriella R, Lopez, Alexandra H, Hudson, Kayla R, Johnson, Eric R, Muthuchamy, Mariappan, Mitchell, Brett M, Rutkowski, Joseph M

“…RATIONALE:Hypertension is associated with renal infiltration of activated immune cells; however, the role of renal lymphatics and immune cell exfiltration is…”
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Augmenting Renal Lymphatic Density Prevents Angiotensin II-Induced Hypertension in Male and Female Mice by Balasubbramanian, Dakshnapriya, Gelston, Catalina A Lopez, Lopez, Alexandra H, Iskander, Geina, Tate, Winter, Holderness, Haley, Rutkowski, Joseph M, Mitchell, Brett M

“…Abstract BACKGROUND Renal inflammation and immune cell infiltration are characteristic of several forms of hypertension. Our laboratory has previously…”
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Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads by Navaneethabalakrishnan, Shobana, Goodlett, Bethany L, Lopez, Alexandra H, Rutkowski, Joseph M, Mitchell, Brett M

“…Hypertension is one of the most prevalent diseases that leads to end organ damage especially affecting the heart, kidney, brain, and eyes. Numerous studies…”
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Genetically inducing renal lymphangiogenesis attenuates hypertension in mice by Goodlett, Bethany L, Balasubbramanian, Dakshnapriya, Navaneethabalakrishnan, Shobana, Love, Sydney E, Luera, Emily M, Konatham, Sunitha, Chiasson, Valorie L, Wedgeworth, Sophie, Rutkowski, Joseph M, Mitchell, Brett M

“…Hypertension (HTN) is associated with renal proinflammatory immune cell infiltration and increased sodium retention. We reported previously that renal…”
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Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization by Onodera, Toshiharu, Wang, May-Yun, Rutkowski, Joseph M., Deja, Stanislaw, Chen, Shiuhwei, Balzer, Michael S., Kim, Dae-Seok, Sun, Xuenan, An, Yu A., Field, Bianca C., Lee, Charlotte, Matsuo, Ei-ichi, Mizerska, Monika, Sanjana, Ina, Fujiwara, Naoto, Kusminski, Christine M., Gordillo, Ruth, Gautron, Laurent, Marciano, Denise K., Hu, Ming Chang, Burgess, Shawn C., Susztak, Katalin, Moe, Orson W., Scherer, Philipp E.

“…Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types…”
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Indole Propionic Acid Increases T Regulatory Cells and Decreases T Helper 17 Cells and Blood Pressure in Mice with Salt-Sensitive Hypertension by Baranwal, Gaurav, Goodlett, Bethany L, Arenaz, Cristina M, Creed, Heidi A, Navaneethabalakrishnan, Shobana, Rutkowski, Joseph M, Alaniz, Robert C, Mitchell, Brett M

“…Hypertension affects over a billion adults worldwide and is a major risk factor for cardiovascular disease. Studies have reported that the microbiota and its…”
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Targeted Deletion of Adipocytes by Apoptosis Leads to Adipose Tissue Recruitment of Alternatively Activated M2 Macrophages by Fischer-Posovszky, Pamela, Wang, Qiong A, Asterholm, Ingrid Wernstedt, Rutkowski, Joseph M, Scherer, Philipp E

“…Obesity is frequently associated with an infiltration of macrophages into adipose tissue. Adipocyte dysfunction causes a phenotypic switch of macrophages from…”
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