Search Results - "Rutitzky, Laura"

Protective immune mechanisms in helminth infection by Gause, William C, Anthony, Robert M, Rutitzky, Laura I, Urban, Joseph F, Stadecker, Miguel J

“…Important insights have recently been gained in our understanding of how host immune responses mediate resistance to parasitic helminths and control associated…”
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Exacerbated egg‐induced immunopathology in murine Schistosoma mansoni infection is primarily mediated by IL‐17 and restrained by IFN‐γ by Rutitzky, Laura I., Stadecker, Miguel J.

“…In schistosomiasis, the severity of CD4+ T‐cell‐mediated hepatic granulomatous inflammation against parasite eggs varies considerably in humans and among mouse…”
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Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity by Washburn, Nathaniel, Schwab, Inessa, Ortiz, Daniel, Bhatnagar, Naveen, Lansing, Jonathan C., Medeiros, Amy, Tyler, Steven, Mekala, Divya, Cochran, Edward, Sarvaiya, Hetal, Garofalo, Kevin, Meccariello, Robin, Meador, James W., Rutitzky, Laura, Schultes, Birgit C., Ling, Leona, Avery, William, Nimmerjahn, Falk, Manning, Anthony M., Kaundinya, Ganesh V., Bosques, Carlos J.

“…Despite the beneficial therapeutic effects of intravenous immunoglobulin (IVIg) in inflammatory diseases, consistent therapeutic efficacy and potency remain…”
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IL-23 Is Required for the Development of Severe Egg-Induced Immunopathology in Schistosomiasis and for Lesional Expression of IL-17 by Rutitzky, Laura I, Bazzone, Lindsey, Shainheit, Mara G, Joyce-Shaikh, Barbara, Cua, Daniel J, Stadecker, Miguel J

“…In infection with the trematode helminth Schistosoma mansoni, the severity of CD4 T cell-mediated hepatic granulomatous and fibrosing inflammation against…”
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Induction and regulation of pathogenic Th17 cell responses in schistosomiasis by Larkin, Bridget M., Smith, Patrick M., Ponichtera, Holly E., Shainheit, Mara G., Rutitzky, Laura I., Stadecker, Miguel J.

“…Schistosomiasis is a major tropical disease caused by trematode helminths in which the host mounts a pathogenic immune response against tissue-trapped parasite…”
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Severe CD4 T Cell-Mediated Immunopathology in Murine Schistosomiasis Is Dependent on IL-12p40 and Correlates with High Levels of IL-17 by Rutitzky, Laura I, Lopes da Rosa, Jessica R, Stadecker, Miguel J

“…C57BL/6 mice infected with the helminth Schistosoma mansoni develop small hepatic granulomas around parasite eggs, but concomitant immunization with soluble…”
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T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17-mediated inflammation by Rutitzky, Laura I, Smith, Patrick M, Stadecker, Miguel J

“…C57BL/6 mice infected with Schistosoma mansoni naturally develop mild CD4⁺ T-cell-mediated immunopathology characterized by small hepatic granulomas around…”
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Dendritic Cell IL-23 and IL-1 Production in Response to Schistosome Eggs Induces Th17 Cells in a Mouse Strain Prone to Severe Immunopathology by Shainheit, Mara G, Smith, Patrick M, Bazzone, Lindsey E, Wang, Andrew C, Rutitzky, Laura I, Stadecker, Miguel J

“…Infection with schistosomes results in a CD4 T cell-mediated inflammatory reaction against parasite eggs that varies greatly in magnitude both in humans as…”
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The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1β by Shainheit, Mara G, Lasocki, Krzysztof W, Finger, Eduardo, Larkin, Bridget M, Smith, Patrick M, Sharpe, Arlene H, Dinarello, Charles A, Rutitzky, Laura I, Stadecker, Miguel J

“…CBA/J mice infected with the helminth Schistosoma mansoni develop severe CD4 T cell-mediated hepatic granulomatous inflammation against parasite eggs…”
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Coinfection with the Intestinal Nematode Heligmosomoides polygyrus Markedly Reduces Hepatic Egg-Induced Immunopathology and Proinflammatory Cytokines in Mouse Models of Severe Schistosomiasis by Bazzone, Lindsey E, Smith, Patrick M, Rutitzky, Laura I, Shainheit, Mara G, Urban, Joseph F, Setiawan, Tommy, Blum, Arthur M, Weinstock, Joel V, Stadecker, Miguel J

“…Infection with the trematode helminth Schistosoma mansoni results in a parasite egg-induced, CD4 T-cell-mediated, hepatointestinal granulomatous and fibrosing…”
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Genetic Control of Severe Egg-Induced Immunopathology and IL-17 Production in Murine Schistosomiasis by Smith, Patrick M, Shainheit, Mara G, Bazzone, Lindsey E, Rutitzky, Laura I, Poltorak, Alexander, Stadecker, Miguel J

“…Infection with the trematode parasite Schistosoma mansoni results in a distinct heterogeneity of disease severity, both in humans and in an experimental mouse…”
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IL‐10 is crucial for the transition from acute to chronic disease state during infection of mice with Schistosoma mansoni by Sadler, Clare H., Rutitzky, Laura I., Stadecker, Miguel J., Wilson, R. Alan

“…After infection of mice with Schistosoma mansoni, deposition of eggs in the walls of the intestine and liver provokes an intense (acute) T cell response that…”
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The immunobiology of Th1 polarization in high-pathology schistosomiasis by Stadecker, Miguel J., Asahi, Hiroko, Finger, Eduardo, Hernandez, Hector J., Rutitzky, Laura I., Sun, Jing

“…Schistosomiasis is a serious global helminthic disease, in which the main immunopathology consists of a granulomatous and fibrosing reaction against…”
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CD4 T cells producing pro-inflammatory interleukin-17 mediate high pathology in schistosomiasis by Rutitzky, Laura I, Stadecker, Miguel J

“…In murine schistosomiasis mansoni, pronounced CD4 T cell-mediated, egg-induced, hepato-intestinal immunopathology and death, whether genetically determined or…”
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Disruption of Interleukin-27 Signaling Results in Impaired Gamma Interferon Production but Does Not Significantly Affect Immunopathology in Murine Schistosome Infection by Shainheit, Mara G, Saraceno, Rosita, Bazzone, Lindsey E, Rutitzky, Laura I, Stadecker, Miguel J

“…In schistosomiasis mansoni, parasite eggs cause hepatointestinal granulomatous inflammation and fibrosis mediated by CD4 T cells specific for egg antigens. The…”
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Th1-Polarizing Immunization with Egg Antigens Correlates with Severe Exacerbation of Immunopathology and Death in Schistosome Infection by Rutitzky, Laura I., Hernandez, Hector J., Stadecker, Miguel J.

“…In schistosomiasis mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammatory process, which is mediated by, and dependent on,…”
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Disruption of the ICOS-B7RP-1 Costimulatory Pathway Leads to Enhanced Hepatic Immunopathology and Increased Gamma Interferon Production by CD4 T Cells in Murine Schistosomiasis by Rutitzky, Laura I, Ozkaynak, Engin, Rottman, James B, Stadecker, Miguel J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Apoptosis by Neglect of CD4+ Th Cells in Granulomas: A Novel Effector Mechanism Involved in the Control of Egg-Induced Immunopathology in Murine Schistosomiasis by Rutitzky, Laura I, Mirkin, Gerardo A, Stadecker, Miguel J

“…In infection with Schistosoma mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammation that is mediated by CD4(+) Th cells…”
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Enhanced egg-induced immunopathology correlates with high IFN-gamma in murine schistosomiasis: identification of two epistatic genetic intervals by Rutitzky, Laura I, Hernandez, Hector J, Yim, Young-Sun, Ricklan, David E, Finger, Eduardo, Mohan, Chandra, Peter, Inga, Wakeland, Edward K, Stadecker, Miguel J

“…The genetic basis of dissimilar immunopathology development among mouse strains infected with Schistosoma mansoni is not known. We performed a multipoint…”
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Diminished immunopathology in Schistosoma mansoni infection following intranasal administration of cholera toxin B‐immunodominant peptide conjugate correlates with enhanced transforming growth factor‐β production by CD4 T cells by Hernandez, Hector J., Rutitzky, Laura I., Lebens, Mike, Holmgren, Jan, Stadecker, Miguel J.

“…Summary In Schistosoma mansoni infection, CD4 T cells specific for parasite egg antigens mediate perioval granuloma formation in the liver and intestines. Mice…”
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