Search Results - "Rutberg, Mikael"

Lipid droplets as dynamic organelles connecting storage and efflux of lipids by Olofsson, Sven-Olof, Boström, Pontus, Andersson, Linda, Rutberg, Mikael, Perman, Jeanna, Borén, Jan

“…Neutral lipids are stored in the cytosol in so-called lipid droplets. These are dynamic organelles with neutral lipids as the core surrounded by a monolayer of…”
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SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity by Andersson, Linda, Ericson, Johanna, Perman, Jeanna, Lidberg, Ulf, Olofsson, Sven-Olof, Boström, Pontus, Johansson, Bengt R, Borén, Jan, Rutberg, Mikael, Fernandez-Rodriguez, Julia, Nilsson, Tommy

“…The accumulation of cytosolic lipid droplets in muscle and liver cells has been linked to the development of insulin resistance and type 2 diabetes. Such…”
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Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice by Håversen, Liliana, Sundelin, Jeanna Perman, Mardinoglu, Adil, Rutberg, Mikael, Ståhlman, Marcus, Wilhelmsson, Ulrika, Hultén, Lillemor Mattsson, Pekny, Milos, Fogelstrand, Per, Bentzon, Jacob Fog, Levin, Malin, Borén, Jan

“…The aim was to clarify the role of vimentin, an intermediate filament protein abundantly expressed in activated macrophages and foam cells, in macrophages…”
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Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico by Mobarak, Edouard, Håversen, Liliana, Manna, Moutusi, Rutberg, Mikael, Levin, Malin, Perkins, Rosie, Rog, Tomasz, Vattulainen, Ilpo, Borén, Jan

“…Toll-like receptor 4 (TLR4) is activated by bacterial lipopolysaccharide (LPS), which drives the production of proinflammatory cytokines. Earlier studies have…”
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PLD1 and ERK2 regulate cytosolic lipid droplet formation by Andersson, Linda, Boström, Pontus, Ericson, Johanna, Rutberg, Mikael, Magnusson, Björn, Marchesan, Denis, Ruiz, Michel, Asp, Lennart, Huang, Ping, Frohman, Michael A, Borén, Jan, Olofsson, Sven-Olof

“…We have previously uncovered roles for phospholipase D (PLD) and an unknown cytosolic protein in the formation of cytosolic lipid droplets using a cell-free…”
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Cytosolic Lipid Droplets Increase in Size by Microtubule-Dependent Complex Formation by Boström, Pontus, Rutberg, Mikael, Ericsson, Johanna, Holmdahl, Peter, Andersson, Linda, Frohman, Michael A, Borén, Jan, Olofsson, Sven-Olof

“…OBJECTIVES—Adipocyte differentiation-related protein (ADRP)-containing lipid droplets have an essential role in the development of insulin resistance and…”
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Triglyceride containing lipid droplets and lipid droplet-associated proteins by Olofsson, Sven-Olof, Boström, Pontus, Andersson, Linda, Rutberg, Mikael, Levin, Malin, Perman, Jeanna, Borén, Jan

“…Cytosolic lipid droplets are now recognized as dynamic organelles. This review summarizes our current understanding of the mechanisms involved in the formation…”
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ARF6 regulates neuron differentiation through glucosylceramide synthase by Li, Lu, Ståhlman, Marcus, Rutberg, Mikael, Håversen, Liliana, Fogelstrand, Per, Andersson, Linda, Levin, Malin, Borén, Jan

“…The small GTPase ADP ribosylation factor 6 (ARF6) mediates endocytosis and has in addition been shown to regulate neuron differentiation. Here we investigated…”
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A Phospholipase D-dependent Process Forms Lipid Droplets Containing Caveolin, Adipocyte Differentiation-related Protein, and Vimentin in a Cell-free System by Marchesan, Denis, Rutberg, Mikael, Andersson, Linda, Asp, Lennart, Larsson, Thomas, Borén, Jan, Johansson, Bengt R., Olofsson, Sven-Olof

“…We developed a microsome-based, cell-free system that assembles newly formed triglyceride (TG) into spherical lipid droplets. These droplets were recovered in…”
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Epigallocatechin gallate increases the formation of cytosolic lipid droplets and decreases the secretion of apoB-100 VLDL by Li, Lu, Stillemark-Billton, Pia, Beck, Caroline, Bostrom, Pontus, Andersson, Linda, Rutberg, Mikael, Ericsson, Johanna, Magnusson, Bjorn, Marchesan, Denis, Ljungberg, Anna, Boren, Jan, Olofsson, Sven-Olof

“…Epigallocatechin gallate (EGCG) increases the formation of cytosolic lipid droplets by a mechanism that is independent of the rate of triglyceride biosynthesis…”
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pH-Dependent Protonation of Histidine Residues Is Critical for Electrostatic LDL (Low-Density Lipoprotein) Binding to Human Coronary Arteries by Glise, Lars, Rutberg, Mikael, Håversen, Liliana, Levin, Malin C., Levin, Max, Jeppsson, Anders, Borén, Jan, Fogelstrand, Per

“…The initiating step in atherogenesis is the electrostatic binding of LDL (low-density lipoprotein) to proteoglycan glycosaminoglycans in the arterial intima…”
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pH-Dependent Protonation of Histidine Residues Is Critical for Electrostatic Binding of Low-Density Lipoproteins to Human Coronary Arteries by Glise, Lars, Rutberg, Mikael, Håversen, Liliana, Levin, Malin C., Levin, Max, Jeppsson, Anders, Borén, Jan, Fogelstrand, Per

“…Background: The initiating step in atherogenesis is the electrostatic binding of LDL (low-density lipoprotein) to proteoglycan glycosaminoglycans in the…”
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Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function by Laudette, Marion, Lindbom, Malin, Arif, Muhammad, Cinato, Mathieu, Ruiz, Mario, Doran, Stephen, Miljanovic, Azra, Rutberg, Mikael, Andersson, Linda, Klevstig, Martina, Henricsson, Marcus, Bergh, Per-Olof, Bollano, Entela, Aung, Nay, Gustav Smith, J, Pilon, Marc, Hyötyläinen, Tuulia, Orešič, Matej, Perkins, Rosie, Mardinoglu, Adil, Levin, Malin C, Borén, Jan

“…Abstract Aims Pro-protein convertase subtilisin-kexin type 9 (PCSK9), which is expressed mainly in the liver and at low levels in the heart, regulates…”
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ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism by Chaudhari, Aditi, Håversen, Liliana, Mobini, Reza, Andersson, Linda, Ståhlman, Marcus, Lu, Emma, Rutberg, Mikael, Fogelstrand, Per, Ekroos, Kim, Mardinoglu, Adil, Levin, Malin, Perkins, Rosie, Borén, Jan

“…Lipid droplet formation, which is driven by triglyceride synthesis, requires several droplet-associated proteins. We identified ARAP2 (an ADP-ribosylation…”
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Statement of Retraction. The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes. Diabetes 2010;59:1870-1878. DOI: 10.2337/db09-1503. PMID: 20460426 by Boström, Pontus, Andersson, Linda, Vind, Birgitte, Håversen, Liliana, Rutberg, Mikael, Wickström, Ylva, Larsson, Erik, Jansson, Per-Anders, Svensson, Maria K, Brånemark, Richard, Ling, Charlotte, Beck-Nielsen, Henning, Borén, Jan, Højlund, Kurt, Olofsson, Sven-Olof

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The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2 diabetes by Boström, Pontus, Andersson, Linda, Vind, Birgitte, Håversen, Liliana, Rutberg, Mikael, Wickström, Ylva, Larsson, Erik, Jansson, Per-Anders, Svensson, Maria K, Brånemark, Richard, Ling, Charlotte, Beck-Nielsen, Henning, Borén, Jan, Højlund, Kurt, Olofsson, Sven-Olof

“…Our previous studies suggest that the SNARE protein synaptosomal-associated protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels…”
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The formation of lipid droplets: possible role in the development of insulin resistance/type 2 diabetes by Olofsson, Sven-Olof, Andersson, Linda, Håversen, Liliana, Olsson, Christina, Myhre, Susanna, Rutberg, Mikael, Mobini, Reza, Li, Lu, Lu, Emma, Borén, Jan, Boström, Pontus

“…Abstract Neutral lipids are stored in so-called lipid droplets, which are formed as small primordial droplets at microsomal membranes and increase in size by a…”
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SNAREs in insulin signaling by Ericson, Johanna, Lagerstedt, Jens, Rutberg, Mikael, Olofsson, Sven-Olof

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The SNARE Protein SNAP23 and the SNARE-Interacting Protein Muncl8c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes by BOSTRÖM, Pontus, ANDERSSON, Linda, LING, Charlotte, BECK-NIELSEN, Henning, BOREN, Jan, HØJLUND, Kurt, OLOFSSON, Sven-Olof, VIND, Birgitte, HAVERSEN, Liliana, RUTBERG, Mikael, WICKSTRÖM, Ylva, LARSSON, Erik, JANSSON, Per-Anders, SVENSSON, Maria K, BRANEMARK, Richard

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Assembly and maturation of lipid droplets: relation to apoB secretion by Olofsson, Sven-Olof, Li, Lu, Andersson, Linda, Boström, Pontus, Lagerstedt, Jens, Rutberg, Mikael

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