Search Results - "Rutar, Matt"

Ocular Lymphatic and Glymphatic Systems: Implications for Retinal Health and Disease by Uddin, Nasir, Rutar, Matt

“…Clearance of ocular fluid and metabolic waste is a critical function of the eye in health and disease. The eye has distinct fluid outflow pathways in both the…”
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Retinal microglia: Just bystander or target for therapy? by Karlstetter, Marcus, Scholz, Rebecca, Rutar, Matt, Wong, Wai T., Provis, Jan M., Langmann, Thomas

“…Resident microglial cells can be regarded as the immunological watchdogs of the brain and the retina. They are active sensors of their neuronal…”
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Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration by Rutar, Matt, Natoli, Riccardo, Provis, Jan M

“…The recruitment and activation of inflammatory cells is thought to exacerbate photoreceptor death in retinal degenerative conditions such as age-related…”
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Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration by Natoli, Riccardo, Fernando, Nilisha, Madigan, Michele, Chu-Tan, Joshua A, Valter, Krisztina, Provis, Jan, Rutar, Matt

“…Chemokine signalling is required for the homing of leukocytes during retinal inflammation, and is associated with pathogenesis of diseases such as age-related…”
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Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration by Natoli, Riccardo, Fernando, Nilisha, Jiao, Haihan, Racic, Tanja, Madigan, Michele, Barnett, Nigel L, Chu-Tan, Joshua A, Valter, Krisztina, Provis, Jan, Rutar, Matt

“…Complement system dysregulation is strongly linked to the progression of age-related macular degeneration (AMD). Deposition of complement including C3 within…”
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Anti-inflammatory and neuroprotective properties of the corticosteroid fludrocortisone in retinal degeneration by Racic, Tanja, Chang, Andrew, Fernando, Nilisha, Brandli, Alice, Natoli, Riccardo, Penfold, Philip, Provis, Jan M., Rutar, Matt

“…The pathogenesis of outer retinal degenerations has been linked to the elevation of cytokines that orchestrate pro-inflammatory responses within the retinal…”
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Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration by Jiao, Haihan, Rutar, Matt, Fernando, Nilisha, Yednock, Ted, Sankaranarayanan, Sethu, Aggio-Bruce, Riemke, Provis, Jan, Natoli, Riccardo

“…The role of the alternative complement pathway and its mediation by retinal microglia and macrophages, is well-established in the pathogenesis of Age-Related…”
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Spatiotemporal Cadence of Macrophage Polarisation in a Model of Light-Induced Retinal Degeneration by Jiao, Haihan, Natoli, Riccardo, Valter, Krisztina, Provis, Jan M, Rutar, Matt

“…The recruitment of macrophages accompanies almost every pathogenic state of the retina, and their excessive activation in the subretinal space is thought to…”
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Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina by Rutar, Matt, Valter, Krisztina, Natoli, Riccardo, Provis, Jan M

“…Complement activation is thought to contribute to the pathogenesis of age-related macular degeneration (AMD), which may be mediated in part by…”
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670nm photobiomodulation as a novel protection against retinopathy of prematurity: evidence from oxygen induced retinopathy models by Natoli, Riccardo, Valter, Krisztina, Barbosa, Marconi, Dahlstrom, Jane, Rutar, Matt, Kent, Alison, Provis, Jan

“…To investigate the validity of using 670nm red light as a preventative treatment for Retinopathy of Prematurity in two animal models of oxygen-induced…”
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Early focal expression of the chemokine Ccl2 by Müller cells during exposure to damage-inducing bright continuous light by Rutar, Matt, Natoli, Riccardo, Valter, Krisztina, Provis, Jan M

“…To investigate the time course and localization of Ccl2 expression and recruitment of inflammatory cells associated with light-induced photoreceptor…”
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The broad-spectrum chemokine inhibitor NR58-3.14.3 modulates macrophage-mediated inflammation in the diseased retina by Fernando, Nilisha, Natoli, Riccardo, Valter, Krisztina, Provis, Jan, Rutar, Matt

“…The activity of macrophages is implicated in the progression of retinal pathologies such as atrophic age-related macular degeneration (AMD), where they…”
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670-nm light treatment reduces complement propagation following retinal degeneration by Rutar, Matt, Natoli, Riccardo, Albarracin, Rizalyn, Valter, Krisztina, Provis, Jan

“…Complement activation is associated with the pathogenesis of age-related macular degeneration (AMD). We aimed to investigate whether 670-nm light treatment…”
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Brief Exposure to Damaging Light Causes Focal Recruitment of Macrophages, and Long-Term Destabilization of Photoreceptors in the Albino Rat Retina by Rutar, Matt, Provis, Jan M., Valter, Krisztina

“…Purpose: To characterize the long-term spatiotemporal features of light-mediated retinal degeneration. Methods: Sprague-Dawley rats were exposed to 1000 lux…”
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Functional microRNA targetome undergoes degeneration-induced shift in the retina by Chu-Tan, Joshua A, Cioanca, Adrian V, Feng, Zhi-Ping, Wooff, Yvette, Schumann, Ulrike, Aggio-Bruce, Riemke, Patel, Hardip, Rutar, Matt, Hannan, Katherine, Panov, Konstantin, Provis, Jan, Natoli, Riccardo

“…MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as…”
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Dynamic Interplay of Innate and Adaptive Immunity During Sterile Retinal Inflammation: Insights From the Transcriptome by Natoli, Riccardo, Mason, Elizabeth, Jiao, Haihan, Chuah, Aaron, Patel, Hardip, Fernando, Nilisha, Valter, Krisztina, Wells, Christine A, Provis, Jan, Rutar, Matt

“…The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined network of sterile inflammatory…”
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Efficacy of 670 nm Light Therapy to Protect against Photoreceptor Cell Death Is Dependent on the Severity of Damage by Natoli, Riccardo, Valter, Krisztina, Howitt, Lauren, Wu, Yunlu, Saxena, Kartik, Rutar, Matt, Chu-Tan, Joshua A., Provis, Jan

“…Photobiomodulation at a wavelength of 670 nm has been shown to be effective in preventing photoreceptor cell death in the retina. We treated Sprague-Dawley…”
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Corrigendum to "Anti-inflammatory and neuroprotective properties of the corticosteroid fludrocortisone in retinal degeneration" Exp. Eye Res. 212 (2021) 108765 by Racic, Tanja, Chang, Andrew, Fernando, Nilisha, Brandli, Alice, Natoli, Riccardo, Penfold, Philip, Provis, Jan M, Rutar, Matt

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Corrigendum to “Anti-inflammatory and neuroprotective properties of the corticosteroid fludrocortisone in retinal degeneration” [Exp. Eye Res. 212 (2021) 108765] by Racic, Tanja, Chang, Andrew, Fernando, Nilisha, Brandli, Alice, Natoli, Riccardo, Penfold, Philip, Provis, Jan M., Rutar, Matt

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Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration by Rutar, Matt, Natoli, Riccardo, Kozulin, Peter, Valter, Krisztina, Gatenby, Paul, Provis, Jan M

“…To investigate the expression and localization of complement system mRNA and protein in a light-induced model of progressive retinal degeneration…”
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