Search Results - "Rusznyák, Ágnes"
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Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers
Published in Scientia pharmaceutica (01-12-2019)“…Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner…”
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Cyclodextrin Complexation Improves the Solubility and Caco-2 Permeability of Chrysin
Published in Materials (16-08-2020)“…Chrysin is a bioflavonoid that can be found in natural products such as honey and propolis, and it possesses several biological effects such as antioxidant,…”
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Block Synthesis and Step-Growth Polymerization of C-6-Sulfonatomethyl-Containing Sulfated Malto-Oligosaccharides and Their Biological Profiling
Published in International journal of molecular sciences (01-01-2024)“…Highly sulfated malto-oligomers, similar to heparin and heparan-sulfate, have good antiviral, antimetastatic, anti-inflammatory and cell growth inhibitory…”
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Preterm Intraventricular Hemorrhage-Induced Inflammatory Response in Human Choroid Plexus Epithelial Cells
Published in International journal of molecular sciences (11-08-2021)“…Following an intraventricular hemorrhage (IVH), red blood cell lysis and hemoglobin (Hb) oxidation with the release of heme can cause sterile…”
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Platelet Microparticles Enriched in miR-223 Reduce ICAM-1-Dependent Vascular Inflammation in Septic Conditions
Published in Frontiers in physiology (31-05-2021)“…In the process of sepsis, activated platelets shed microvesicles containing microRNAs (miRNAs), which can be internalized by distinct recipient cells in…”
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Comparative Investigation of Cellular Effects of Polyethylene Glycol (PEG) Derivatives
Published in Polymers (11-01-2022)“…Nowadays, polyethylene glycols referred to as PEGs are widely used in cosmetics, consumer care products, and the pharmaceutical industry. Their advantageous…”
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Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis
Published in International journal of molecular sciences (29-01-2020)“…In sepsis, platelets may become activated via toll-like receptors (TLRs), causing microvascular thrombosis. Megakaryocytes (MKs) also express these receptors;…”
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Effects of Hydroxypropyl-Beta-Cyclodextrin on Cultured Brain Endothelial Cells
Published in Molecules (Basel, Switzerland) (10-11-2022)“…The application of 2-hydroxypropyl-beta-cyclodextrin (HPBCD) in the treatment of the rare cholesterol and lipid storage disorder Niemann-Pick disease type C…”
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Cellular Effects of Cyclodextrins: Studies on HeLa Cells
Published in Molecules (Basel, Switzerland) (28-02-2022)“…Cyclodextrins are high molecular weight, hydrophilic, cyclic, non-reducing oligosaccharides, applied as excipients for the improvement of the solubility and…”
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Chrysin Directing an Enhanced Solubility through the Formation of a Supramolecular Cyclodextrin-Calixarene Drug Delivery System: A Potential Strategy in Antifibrotic Diabetes Therapeutics
Published in Pharmaceuticals (Basel, Switzerland) (01-01-2024)“…Calixarene 0118 (OTX008) and chrysin (CHR) are promising molecules for the treatment of fibrosis and diabetes complications but require an effective delivery…”
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Synthesis and Biological Profiling of Seven Heparin and Heparan Sulphate Analogue Trisaccharides
Published in Biomolecules (Basel, Switzerland) (01-09-2024)“…Researchers are paying increasing attention to the strongly negatively charged heteropolysaccharides in cells, in the extracellular matrix or in the cell wall…”
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Investigation of the Drug Carrier Properties of Insoluble Cyclodextrin Polymer Microspheres
Published in Biomolecules (Basel, Switzerland) (02-07-2022)“…The investigation of the usability of solid insoluble β-cyclodextrin polymers (βCDP) in micro-sized, controlled drug delivery systems has only recently…”
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Electroretinographical Analysis of the Effect of BGP-15 in Eyedrops for Compensating Global Ischemia-Reperfusion in the Eyes of Sprague Dawley Rats
Published in Biomedicines (01-03-2024)“…Retinal vascular diseases and consequential metabolic disturbances in the eye are major concerns for healthcare systems all around the world. BGP-15, a drug…”
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Preformulation Studies and Bioavailability Enhancement of Curcumin with a 'Two in One' PEG-β-Cyclodextrin Polymer
Published in Pharmaceutics (16-10-2021)“…Drug delivery systems are used to improve the biopharmaceutical properties of curcumin. Our aim was to investigate the effect of a water-soluble 'two in one'…”
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Investigation of the Cellular Effects of Beta- Cyclodextrin Derivatives on Caco-2 Intestinal Epithelial Cells
Published in Pharmaceutics (25-01-2021)“…Cyclodextrins are widely used excipients for increasing water-solubility, delivery and bioavailability of lipophilic drugs. By using fluorescent cyclodextrin…”
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Pharmacokinetic Properties of Fluorescently Labelled Hydroxypropyl-Beta-Cyclodextrin
Published in Biomolecules (Basel, Switzerland) (20-09-2019)“…2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is utilized in the formulation of pharmaceutical products and recently orphan designation was granted for the…”
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Radiochemical synthesis and preclinical evaluation of 68Ga-labeled NODAGA-hydroxypropyl-beta-cyclodextrin (68Ga-NODAGA-HPBCD)
Published in European journal of pharmaceutical sciences (01-02-2019)“…A new renaissance started in the research and application of cyclodextrins a few years ago. 2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is used in the…”
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18
Matrix systems for oral drug delivery: Formulations and drug release
Published in Drug discovery today. Technologies (01-07-2018)“…In this current article matrix formulations for oral drug delivery are reviewed. Conventional dosage forms and novel applications such as 3D printed matrices…”
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Radiochemical synthesis and preclinical evaluation of 68 Ga-labeled NODAGA-hydroxypropyl-beta-cyclodextrin ( 68 Ga-NODAGA-HPBCD)
Published in European journal of pharmaceutical sciences (04-12-2018)“…A new renaissance started in the research and application of cyclodextrins a few years ago. 2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is used in the…”
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Process Optimization for the Continuous Production of a Gastroretentive Dosage Form Based on Melt Foaming
Published in AAPS PharmSciTech (21-06-2021)“…Several drugs have poor oral bioavailability due to low or incomplete absorption which is affected by various effects as pH, motility of GI, and enzyme…”
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