Search Results - "Ruszkowski, Piotr"

Acylation of Oleanolic Acid Oximes Effectively Improves Cytotoxic Activity in In Vitro Studies by Bednarczyk-Cwynar, Barbara, Ruszkowski, Piotr

“…(1) Background: The aim of the presented work was to obtain a set of oleanolic acid derivatives with a high level of anticancer activity and a low level of…”
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Acetylation of Oleanolic Acid Dimers as a Method of Synthesis of Powerful Cytotoxic Agents by Günther, Andrzej, Zalewski, Przemysław, Sip, Szymon, Ruszkowski, Piotr, Bednarczyk-Cwynar, Barbara

“…Oleanolic acid, a naturally occurring triterpenoid compound, has garnered significant attention in the scientific community due to its diverse pharmacological…”
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Oleanolic Acid Dimers with Potential Application in Medicine-Design, Synthesis, Physico-Chemical Characteristics, Cytotoxic and Antioxidant Activity by Günther, Andrzej, Zalewski, Przemysław, Sip, Szymon, Ruszkowski, Piotr, Bednarczyk-Cwynar, Barbara

“…The present work aimed to obtain a set of oleanolic acid derivatives with a high level of cytotoxic and antioxidant activities and a low level of toxicity by…”
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Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs by Pyta, Krystian, Skrzypczak, Natalia, Ruszkowski, Piotr, Bartl, Franz, Przybylski, Piotr

“…The influence of base type, temperature, and solvent on regioselective C(9)/C(10) "click" modifications within the tropolone ring of colchiceine (2) is…”
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Effects of combined statin and ACE inhibitor therapy on endothelial function and blood pressure in essential hypertension - a randomised double-blind, placebo controlled crossover study by Ruszkowski, Piotr, Masajtis-Zagajewska, Anna, Nowicki, Michał

“…Background: The aim of this study was to compare the influence of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on endothelial function and blood…”
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Bioactive Betulin and PEG Based Polyanhydrides for Use in Drug Delivery Systems by Niewolik, Daria, Bednarczyk-Cwynar, Barbara, Ruszkowski, Piotr, Sosnowski, Tomasz R, Jaszcz, Katarzyna

“…In the course of this study, a series of novel, biodegradable polyanhydrides based on betulin disuccinate and dicarboxylic derivatives of poly(ethylene glycol)…”
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Highly Branched Betulin Based Polyanhydrides for Self-Assembled Micellar Nanoparticles Formulation by Niewolik, Daria, Bednarczyk-Cwynar, Barbara, Ruszkowski, Piotr, Dzido, Grzegorz, Jaszcz, Katarzyna

“…Polyanhydrides based on betulin are promising materials for use in controlled drug delivery systems. Due to the broad biological activity of betulin…”
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EGDMA- and TRIM-Based Microparticles Imprinted with 5-Fluorouracil for Prolonged Drug Delivery by Cegłowski, Michał, Kurczewska, Joanna, Lusina, Aleksandra, Nazim, Tomasz, Ruszkowski, Piotr

“…Imprinted materials possess designed cavities capable of forming selective interactions with molecules used in the imprinting process. In this work, we report…”
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Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators by Skrzypczak, Natalia, Pyta, Krystian, Ruszkowski, Piotr, Mikołajczak, Przemysław, Kucińska, Małgorzata, Murias, Marek, Gdaniec, Maria, Bartl, Franz, Przybylski, Piotr

“…Geldanamycin (GDM) has been modified by different type neutral/acidic/basic substituents (1-7) and by quinuclidine motif (8), transformed into ammonium salts…”
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Oleanolic Acid A-lactams Inhibit the Growth of HeLa, KB, MCF-7 and Hep-G2 Cancer Cell Lines at Micromolar Concentrations by Bednarczyk-Cwynar, Barbara, Ruszkowski, Piotr, Bobkiewicz-Kozlowska, Teresa, Zaprutko, Lucjusz

“…Oleanolic acid ketones, oximes, lactams and nitriles were obtained. Complete spectral characterizations (IR, (1)H NMR, (13)C NMR, DEPT and MS) of the…”
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Biodegradable and Bioactive Carriers Based on Poly(betulin disuccinate- co -sebacic Acid) for Rifampicin Delivery by Niewolik, Daria, Bednarczyk-Cwynar, Barbara, Ruszkowski, Piotr, Kazek-Kęsik, Alicja, Dzido, Grzegorz, Jaszcz, Katarzyna

“…This paper describes the preparation and characterization of polymer-drug systems based on polymeric microspheres obtained from poly(betulin disuccinate-…”
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SBA-15 Mesoporous Silica Modified with Gallic Acid and Evaluation of Its Cytotoxic Activity by Lewandowski, Dawid, Ruszkowski, Piotr, Pińska, Anita, Schroeder, Grzegorz, Kurczewska, Joanna

“…Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers. Cytotoxic activity of the hybrid organic-inorganic…”
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Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity by Lewandowski, Dawid, Lewandowska, Marta, Ruszkowski, Piotr, Pińska, Anita, Schroeder, Grzegorz

“…Novel zidovudine derivatives, able to be covalently conjugated to silica surface, have been obtained and grafted to SBA-15 mesoporous silica. Cytotoxic…”
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Biomimetic Multispiked Connecting Ti-Alloy Scaffold Prototype for Entirely-Cementless Resurfacing Arthroplasty Endoprostheses-Exemplary Results of Implantation of the Ca-P Surface-Modified Scaffold Prototypes in Animal Model and Osteoblast Culture Evaluation by Uklejewski, Ryszard, Rogala, Piotr, Winiecki, Mariusz, Tokłowicz, Renata, Ruszkowski, Piotr, Wołuń-Cholewa, Maria

“…We present here-designed, manufactured, and tested by our research team-the Ti-alloy prototype of the multispiked connecting scaffold (MSC-Scaffold)…”
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Synthesis and in vitro anticancer activity of N-alkyl phosphoramidate monoesters of 3’-azido-3’-deoxythymidine (AZT) by Czajkowska-Wojciechowska, Ewa, Singh, Aleksandra, Trznadel, Roksana, Ruszkowski, Piotr, Celewicz, Lech

“…In this study, a series of novel N-alkyl phosphoramidate monoesters of 3’-azido-3’-deoxythymidine (AZT) were synthesized using two methods. The synthesized…”
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Stroke prevention in atrial fibrillation patients in Poland and other European countries: insights from the GARFIELD-AF registry by Stępińska, Janina, Kremis, Elżbieta, Konopka, Anna, Wożakowska-Kapłon, Beata, Ruszkowski, Piotr, Kukla, Piotr, Kayani, Gloria

“…Atrial fibrillation (AF) is the most common clinically-significant arrhythmia in the adult population, and it is a strong independent risk factor for…”
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Application of paclitaxel-imprinted microparticles obtained using two different cross-linkers for prolonged drug delivery by Cegłowski, Michał, Kurczewska, Joanna, Ruszkowski, Piotr, Schroeder, Grzegorz

“…[Display omitted] •Paclitaxel-imprinted microparticles were obtained using two different cross-linkers.•The influence of TRIM and EGDMA cross-linkers on MIPs…”
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Nucleoside dimers analogues with a 1,2,3-triazole linkage: conjugation of floxuridine and thymidine provides novel tools for cancer treatment. Part II by Baraniak, Dagmara, Baranowski, Daniel, Ruszkowski, Piotr, Boryski, Jerzy

“…The fluorinated nucleoside dimers with a 1,2,3-triazole linkage are novel compounds within the field of bioorganic chemistry. We report on the synthesis and…”
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Cascade Transformation of the Ansamycin Benzoquinone Core into Benzoxazole Influencing Anticancer Activity and Selectivity by Skrzypczak, Natalia, Pyta, Krystian, Bohusz, Wiktor, Leśniewska, Aleksandra, Gdaniec, Maria, Ruszkowski, Piotr, Schilf, Wojciech, Bartl, Franz, Przybylski, Piotr

“…The metal-free cascade transformation of geldanamycin benzoquinone core is proposed at relatively mild conditions. This approach yields new benzoxazole…”
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Synthesis, structure and anticancer activity of new geldanamycin amine analogs containing C(17)- or C(20)- flexible and rigid arms as well as closed or open ansa-bridges by Skrzypczak, Natalia, Pyta, Krystian, Ruszkowski, Piotr, Gdaniec, Maria, Bartl, Franz, Przybylski, Piotr

“…The nucleophilic attack of amines at C(17) or C(17)/C(20) positions of geldanamycin’s (GDM) benzoquinone, via initial 1,4-Michael conjugate addition mechanism,…”
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