Search Results - "Rustenhoven, Justin"

Brain borders at the central stage of neuroimmunology by Rustenhoven, Justin, Kipnis, Jonathan

“…The concept of immune privilege suggests that the central nervous system is isolated from the immune system. However, recent studies have highlighted the…”
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Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease by Alves de Lima, Kalil, Rustenhoven, Justin, Kipnis, Jonathan

“…Neuroimmunology, albeit a relatively established discipline, has recently sparked numerous exciting findings on microglia, the resident macrophages of the…”
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Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons by Alves de Lima, Kalil, Rustenhoven, Justin, Da Mesquita, Sandro, Wall, Morgan, Salvador, Andrea Francesca, Smirnov, Igor, Martelossi Cebinelli, Guilherme, Mamuladze, Tornike, Baker, Wendy, Papadopoulos, Zach, Lopes, Maria Beatriz, Cao, William Sam, Xie, Xinmin Simon, Herz, Jasmin, Kipnis, Jonathan

“…Interleukin (IL)-17a has been highly conserved during evolution of the vertebrate immune system and widely studied in contexts of infection and autoimmunity…”
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Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma by Cugurra, Andrea, Mamuladze, Tornike, Rustenhoven, Justin, Dykstra, Taitea, Beroshvili, Giorgi, Greenberg, Zev J, Baker, Wendy, Papadopoulos, Zach, Drieu, Antoine, Blackburn, Susan, Kanamori, Mitsuhiro, Brioschi, Simone, Herz, Jasmin, Schuettpelz, Laura G, Colonna, Marco, Smirnov, Igor, Kipnis, Jonathan

“…The meninges are a membranous structure enveloping the central nervous system (CNS) that host a rich repertoire of immune cells mediating CNS immune…”
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Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair by Avraham, Oshri, Feng, Rui, Ewan, Eric Edward, Rustenhoven, Justin, Zhao, Guoyan, Cavalli, Valeria

“…Sensory neurons with cell bodies in dorsal root ganglia (DRG) represent a useful model to study axon regeneration. Whereas regeneration and functional recovery…”
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Brain Pericytes As Mediators of Neuroinflammation by Rustenhoven, Justin, Jansson, Deidre, Smyth, Leon C, Dragunow, Mike

“…Brain pericytes are perivascular cells that regulate capillary function, and this localization puts them in a pivotal position for the regulation of central…”
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Functional characterization of the dural sinuses as a neuroimmune interface by Rustenhoven, Justin, Drieu, Antoine, Mamuladze, Tornike, de Lima, Kalil Alves, Dykstra, Taitea, Wall, Morgan, Papadopoulos, Zachary, Kanamori, Mitsuhiro, Salvador, Andrea Francesca, Baker, Wendy, Lemieux, Mackenzie, Da Mesquita, Sandro, Cugurra, Andrea, Fitzpatrick, James, Sviben, Sanja, Kossina, Ross, Bayguinov, Peter, Townsend, Reid R., Zhang, Qiang, Erdmann-Gilmore, Petra, Smirnov, Igor, Lopes, Maria-Beatriz, Herz, Jasmin, Kipnis, Jonathan

“…Despite the established dogma of central nervous system (CNS) immune privilege, neuroimmune interactions play an active role in diverse neurological disorders…”
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Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels by Mazzitelli, Jose A., Smyth, Leon C. D., Cross, Kevin A., Dykstra, Taitea, Sun, Jerry, Du, Siling, Mamuladze, Tornike, Smirnov, Igor, Rustenhoven, Justin, Kipnis, Jonathan

“…It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull…”
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Routine culture and study of adult human brain cells from neurosurgical specimens by Park, Thomas I.-H., Smyth, Leon C. D., Aalderink, Miranda, Woolf, Zoe R., Rustenhoven, Justin, Lee, Kevin, Jansson, Deidre, Smith, Amy, Feng, Sheryl, Correia, Jason, Heppner, Peter, Schweder, Patrick, Mee, Edward, Dragunow, Mike

“…When modeling disease in the laboratory, it is important to use clinically relevant models. Patient-derived human brain cells grown in vitro to study and test…”
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TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function by Rustenhoven, Justin, Aalderink, Miranda, Scotter, Emma L, Oldfield, Robyn L, Bergin, Peter S, Mee, Edward W, Graham, E Scott, Faull, Richard L M, Curtis, Maurice A, Park, Thomas I-H, Dragunow, Mike

“…Transforming growth factor beta 1 (TGFβ1) is strongly induced following brain injury and polarises microglia to an anti-inflammatory phenotype. Augmentation of…”
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Isolation of highly enriched primary human microglia for functional studies by Rustenhoven, Justin, Park, Thomas I-H, Schweder, Patrick, Scotter, John, Correia, Jason, Smith, Amy M., Gibbons, Hannah M., Oldfield, Robyn L., Bergin, Peter S., Mee, Edward W., Faull, Richard L. M., Curtis, Maurice A., Scott Graham, E., Dragunow, Mike

“…Microglia, the resident macrophages of the central nervous system play vital roles in brain homeostasis through clearance of pathogenic material. Microglia are…”
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Unique and shared inflammatory profiles of human brain endothelia and pericytes by Smyth, Leon C D, Rustenhoven, Justin, Park, Thomas I-H, Schweder, Patrick, Jansson, Deidre, Heppner, Peter A, O'Carroll, Simon J, Mee, Edward W, Faull, Richard L M, Curtis, Maurice, Dragunow, Mike

“…Pericytes and endothelial cells are critical cellular components of the blood-brain barrier (BBB) and play an important role in neuroinflammation. To date, the…”
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A role for human brain pericytes in neuroinflammation by Jansson, Deidre, Rustenhoven, Justin, Feng, Sheryl, Hurley, Daniel, Oldfield, Robyn L, Bergin, Peter S, Mee, Edward W, Faull, Richard L M, Dragunow, Mike

“…Brain inflammation plays a key role in neurological disease. Although much research has been conducted investigating inflammatory events in animal models,…”
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Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease by Smyth, Leon C. D., Highet, Blake, Jansson, Deidre, Wu, Jane, Rustenhoven, Justin, Aalderink, Miranda, Tan, Adelie, Li, Susan, Johnson, Rebecca, Coppieters, Natacha, Handley, Renee, Narayan, Pritika, Singh-Bains, Malvindar K., Schweder, Patrick, Turner, Clinton, Mee, Edward W., Heppner, Peter, Correia, Jason, Park, Thomas I.-H., Curtis, Maurice A., Faull, Richard L. M., Dragunow, Mike

“…Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and function of…”
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Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress by Stevenson, Taylor J., Johnson, Rebecca H., Savistchenko, Jimmy, Rustenhoven, Justin, Woolf, Zoe, Smyth, Leon C. D., Murray, Helen C., Faull, Richard L. M., Correia, Jason, Schweder, Patrick, Heppner, Peter, Turner, Clinton, Melki, Ronald, Dieriks, Birger V., Curtis, Maurice A., Dragunow, Michael

“…Parkinson’s disease (PD) is characterised by the progressive loss of midbrain dopaminergic neurons and the presence of aggregated α-synuclein (α-syn)…”
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Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus by Jansson, Deidre, Dieriks, Victor Birger, Rustenhoven, Justin, Smyth, Leon C. D., Scotter, Emma, Aalderink, Miranda, Feng, Sheryl, Johnson, Rebecca, Schweder, Patrick, Mee, Edward, Heppner, Peter, Turner, Clinton, Curtis, Maurice, Faull, Richard, Dragunow, Mike

“…Neuroinflammation is a key component of virtually all neurodegenerative diseases, preceding neuronal loss and associating directly with cognitive impairment…”
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A privileged brain by Rustenhoven, Justin

“…Local neuroimmune collaboration safeguards the central nervous system…”
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Age‐related alterations in meningeal immunity drive impaired central nervous system waste removal by Rustenhoven, Justin

“…Background The meningeal lymphatic network enables the drainage of cerebrospinal fluid (CSF) and facilitates the removal of central nervous system (CNS) waste…”
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PU.1 regulates Alzheimer's disease-associated genes in primary human microglia by Rustenhoven, Justin, Smith, Amy M, Smyth, Leon C, Jansson, Deidre, Scotter, Emma L, Swanson, Molly E V, Aalderink, Miranda, Coppieters, Natacha, Narayan, Pritika, Handley, Renee, Overall, Chris, Park, Thomas I H, Schweder, Patrick, Heppner, Peter, Curtis, Maurice A, Faull, Richard L M, Dragunow, Mike

“…Microglia play critical roles in the brain during homeostasis and pathological conditions. Understanding the molecular events underpinning microglial functions…”
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Bypassing the blood-brain barrier by Rustenhoven, Justin, Kipnis, Jonathan

“…The meninges membranes surrounding the brain are an immune-blood-brain interface in homeostasis and disease Brain function requires tight regulation of the…”
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